60 days in South America Itinerary

60 days in South America Itinerary

Created using Inspirock South America tour itinerary builder

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1
Pereira, Colombia
— 1 night
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2
Medellin, Colombia
— 2 nights
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3
Cartagena, Colombia
— 1 night
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Santa Marta, Colombia
— 2 nights
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Maracaibo, Venezuela
— 2 nights
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Caracas, Venezuela
— 3 nights
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Ciudad Guayana, Venezuela
— 1 night
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Boa Vista, Brazil
— 1 night
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Manaus, Brazil
— 3 nights
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Ariquemes, Brazil
— 1 night
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Vilhena, Brazil
— 1 night
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Sinop, Brazil
— 1 night
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Canarana, Brazil
— 1 night
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Araguacema, Brazil
— 1 night
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Maraba, Brazil
— 1 night
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Sao Luis, Brazil
— 2 nights
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Fortaleza, Brazil
— 3 nights
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Natal, Brazil
— 2 nights
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Porto de Galinhas, Brazil
— 2 nights
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Salvador, Brazil
— 1 night
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Guanambi, Brazil
— 1 night
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Brasilia, Brazil
— 2 nights
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Belo Horizonte, Brazil
— 1 night
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Rio de Janeiro, Brazil
— 3 nights
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Sao Paulo, Brazil
— 3 nights
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Curitiba, Brazil
— 2 nights
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Puerto Iguazu, Argentina
— 2 nights
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Asuncion, Paraguay
— 3 nights
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Encarnacion, Paraguay
— 2 nights
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Salto, Uruguay
— 2 nights
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Montevideo, Uruguay
— 3 nights
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Colonia del Sacramento, Uruguay
— 2 nights
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Gualeguaychu, Argentina
— 1 night
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Pereira, Colombia

— 1 night
A center of commerce and trade, the thriving city of Pereira was founded in 1863.
Kick off your visit on the 15th (Tue): see the interesting displays at Museo de Arte de Pereira and then buy something for everyone on your list at Centro Comercial Pereira Plaza.

For reviews, where to stay, traveler tips, and other tourist information, you can read our Pereira travel route planner.

Bogota to Pereira is an approximately 3-hour flight. You can also do a combination of flight and bus; or drive. In March, Pereira is somewhat warmer than Bogota - with highs of 32°C and lows of 21°C. Cap off your sightseeing on the 16th (Wed) early enough to catch the flight to Medellin.

Things to do in Pereira

Museums · Shopping

Medellin, Colombia

— 2 nights

City of the Eternal Spring

Nestled between rising hills in a narrow valley, Medellin serves as an energetic melting pot of people from all socio-economic classes.
On the 16th (Wed), steep yourself in history at Pueblito Paisa, get engrossed in the history at Museo de Antioquia, then relax and rejuvenate at some of the best spas, and finally stroll around Parques del Rio. Get ready for a full day of sightseeing on the next day: identify plant and animal life at Parque Arvi, pause for some serene contemplation at Templo Parroquial Jesus Nazareno, then glide through the air with a parasailing or paragliding tour, and finally indulge your thirst for a good beer at 3 Cordilleras.

To see reviews, other places to visit, maps, and other tourist information, refer to the Medellin trip itinerary planning website.

Getting from Pereira to Medellin by flight takes about 3 hours. Other options: drive; or take a bus. In March in Medellin, expect temperatures between 32°C during the day and 21°C at night. Finish up your sightseeing early on the 18th (Fri) so you can catch the flight to Cartagena.

Things to do in Medellin

Parks · Wildlife · Breweries & Distilleries · Historic Sites

Cartagena, Colombia

— 1 night

City of Heroes

The site of the continent's first Spanish colony, Cartagena retains much of its colonial flavor thanks to a World Heritage-listed old town, encircled by old walls and protected by imposing fortresses.
Kick off your visit on the 18th (Fri): explore the historical opulence of Castillo de San Felipe de Barajas and then steep yourself in history at Walled City of Cartagena.

To find ratings, photos, reviews, and other tourist information, read Cartagena travel itinerary planner.

You can fly from Medellin to Cartagena in 3 hours. Other options are to drive; or take a bus. In March, Cartagena is somewhat warmer than Medellin - with highs of 37°C and lows of 29°C. Finish your sightseeing early on the 19th (Sat) to allow enough time to drive to Santa Marta.

Things to do in Cartagena

Historic Sites

Santa Marta, Colombia

— 2 nights

America's Pearl

Many visitors begin their Santa Marta holiday, surrounded by urban clutter and heavy traffic, expecting little from the city in terms of historical importance.
Start off your visit on the 19th (Sat): admire the masterpieces at Quinta de San Pedro Alejandrino, kick back and relax at Playa Blanca, then pause for some serene contemplation at Catedral de Santa Marta, and finally buy something for everyone on your list at Centro Comercial Zazue Plaza. Get ready for a full day of sightseeing on the 20th (Sun): identify plant and animal life at Wildlife Areas.

To find more things to do, reviews, other places to visit, and more tourist information, read Santa Marta trip builder app.

You can drive from Cartagena to Santa Marta in 3.5 hours. Another option is to take a bus. Expect a daytime high around 39°C in March, and nighttime lows around 29°C. Finish up your sightseeing early on the 21st (Mon) so you can travel to Maracaibo.

Things to do in Santa Marta

Outdoors · Wildlife · Tours · Historic Sites

Maracaibo, Venezuela

— 2 nights

Beloved Land of the Sun

Home to more than 2 million residents, Maracaibo boasts giant shopping malls and attractive parks, as well as a modern skyline that hugs the shore of an eponymous lake.
Kick off your visit on the 21st (Mon): Head underground at Cuevas de Saman and then pause for some serene contemplation at Basílica de Nuestra Señora del Rosario de Chiquinquirá. Keep things going the next day: see the interesting displays at Museo Historico Rafael Urdaneta, then stroll around La vereda del lago Maracaibo, then indulge in some personalized pampering at Calantha Spa, and finally explore the landscape on two wheels at Paseo del Lago 3.

For where to stay, photos, other places to visit, and other tourist information, read our Maracaibo trip itinerary tool.

Traveling by car from Santa Marta to Maracaibo takes 7 hours. Due to the time zone difference, you'll lose 1 hour traveling from Santa Marta to Maracaibo. In March in Maracaibo, expect temperatures between 39°C during the day and 29°C at night. Wrap up your sightseeing on the 23rd (Wed) to allow time to fly to Caracas.

Things to do in Maracaibo

Parks · Historic Sites · Museums · Trails

Caracas, Venezuela

— 3 nights

Heaven's Branch on Earth

Tropical weather, great food, and memorable jungle surroundings seem like all the ingredients Caracas needs to become a must-see destination.
Visit Iglesia de San Francisco and Iglesia Sagrado Corazon de Jesus for their historical value. Get some cultural insight at Museo de Bellas Artes and Plaza Francia. And it doesn't end there: get outside with Parque Nacional el Avila, get engrossed in the history at Casa Natal & Museo Bolivar, admire the masterpieces at Hacienda La Trinidad Parque Cultural, and take in the architecture and atmosphere at Iglesia Nuestra Senora de Las Mercedes.

Use Inspirock's suggestions to plan your Caracas trip and find the best activities and attractions for your vacation.

Traveling by flight from Maracaibo to Caracas takes 2.5 hours. Alternatively, you can drive; or take a bus. Finish your sightseeing early on the 26th (Sat) so you can fly to Ciudad Guayana.

Things to do in Caracas

Historic Sites · Museums · Outdoors · Shopping

Ciudad Guayana, Venezuela

— 1 night
Located on the Orinoco River, Ciudad Guayana represents one of Venezuela's fastest-growing cities, with plenty of natural and man-made highlights on offer.
On the 26th (Sat), get outside with Parque Cachamay and then take in the architecture and atmosphere at Iglesia Virgen del Valle.

To find reviews, other places to visit, where to stay, and other tourist information, refer to the Ciudad Guayana vacation planning app.

Getting from Caracas to Ciudad Guayana by flight takes about 2.5 hours. Other options: drive; or take a bus. Traveling from Caracas to Ciudad Guayana, you'll gain 1 hour due to the time zone difference. Wrap up your sightseeing on the 27th (Sun) early enough to travel to Boa Vista.

Things to do in Ciudad Guayana

Historic Sites · Outdoors

Boa Vista, Brazil

— 1 night
The capital of the state of Roraima, and home to roughly half its population, the planned city of Boa Vista was established in 1890 and designed according to an innovative radial shape.
For more things to do, ratings, reviews, and more tourist information, refer to the Boa Vista road trip tool.

Traveling by car from Ciudad Guayana to Boa Vista takes 13.5 hours. The time zone difference when traveling from Ciudad Guayana to Boa Vista is 1 hour. March in Boa Vista sees daily highs of 38°C and lows of 28°C at night. You will leave for Manaus on the 28th (Mon).

Things to do in Boa Vista

Parks · Nature · Outdoors · Nightlife

Manaus, Brazil

— 3 nights

Paris of the Tropics

It's hard not to get excited when planning a trip to Manaus, capital of the state of Amazonas, and the largest city on the mighty Amazon River.
Kick off your visit on the 29th (Tue): browse the different shops at Manauara Shopping, get a new perspective on nature at Museu da Amazonia (MUSA), stroll through Ponta Negra Beach, then look for gifts at Galeria Amazonica, and finally don't miss a visit to Espaco Cultural Largo de Sao Sebastiao. On the 30th (Wed), you'll have a packed day of sightseeing: contemplate the waterfront views at Meeting of Waters, paddle through the water with a kayaking and canoeing tour, and then pause for some serene contemplation at Church of Sao Sebastiao e Sao Francisco de Assis.

Plan my day in Manaus using traveler tips and tourist information provided by Inspirock.

You can drive from Boa Vista to Manaus in 12 hours. Traveling from Boa Vista in March, you will find days in Manaus are little chillier (34°C), and nights are about the same (27°C). Wrap up your sightseeing on the 31st (Thu) to allow time to travel to Ariquemes.

Things to do in Manaus

Outdoors · Wildlife · Tours · Adventure

Ariquemes, Brazil

— 1 night
Ariquemes is a municipality located in the Brazilian state of Rondônia. To find reviews, where to stay, and tourist information, you can read our Ariquemes road trip site.

The Route module can help you plan travel from Manaus to Ariquemes. In March in Ariquemes, expect temperatures between 36°C during the day and 27°C at night. You will leave for Vilhena on the 1st (Fri).

Things to do in Ariquemes

Parks · Museums

Vilhena, Brazil

— 1 night
Vilhena is the easternmost municipality in the Brazilian state of Rondônia. Start off your visit on the 1st (Fri): buy something for everyone on your list at Park Shopping Vilhena, examine the collection at House of Rondon, and then pause for some serene contemplation at Igreja De Nossa Senhora Aparecida.

To see traveler tips, more things to do, reviews, and more tourist information, refer to the Vilhena day trip website.

You can drive from Ariquemes to Vilhena in 7.5 hours. Another option is to fly. Traveling from Ariquemes in April, expect little chillier with lows of 24°C in Vilhena. Finish your sightseeing early on the 2nd (Sat) so you can travel to Sinop.

Things to do in Vilhena

Historic Sites · Museums · Shopping

Sinop, Brazil

— 1 night
Start off your visit on the 2nd (Sat): pause for some serene contemplation at Catedral Sagrado Coracao de Jesus.

To find reviews, other places to visit, ratings, and other tourist information, go to the Sinop trip planner.

You can drive from Vilhena to Sinop in 11 hours. Alternatively, you can fly. Finish your sightseeing early on the 3rd (Sun) to allow enough time to travel to Canarana.

Things to do in Sinop

Historic Sites
Highlights from your trip

Canarana, Brazil

— 1 night
Kick off your visit on the 3rd (Sun): make a trip to Igreja Matriz Nossa Senhora Auxiliadora.

To see traveler tips, photos, where to stay, and more tourist information, read our Canarana trip tool.

The Route module can help you plan travel from Sinop to Canarana. Finish up your sightseeing early on the 4th (Mon) so you can travel to Araguacema.
Highlights from your trip

Araguacema, Brazil

— 1 night
Araguacema is a municipality located in the Brazilian state of Tocantins. To find where to stay, traveler tips, and tourist information, use the Araguacema trip planner.

Drive from Canarana to Araguacema in 12.5 hours. Alternatively, you can fly. Due to the time zone difference, you'll lose 1 hour traveling from Canarana to Araguacema. In April in Araguacema, expect temperatures between 38°C during the day and 27°C at night. You'll set off for Maraba on the 5th (Tue).

Things to do in Araguacema

Outdoors

Maraba, Brazil

— 1 night
Marabá is a municipality in the state of Pará, Brazil. On the 5th (Tue), head outdoors with Praia do Tucunare, then examine the collection at Maraba Municipal Museum, and then examine the collection at Pedro Morbach Municipal Arts Museum.

For where to stay, other places to visit, traveler tips, and other tourist information, refer to the Maraba sightseeing site.

Traveling by car from Araguacema to Maraba takes 9 hours. Alternatively, you can fly. In April, daytime highs in Maraba are 38°C, while nighttime lows are 27°C. Wrap up your sightseeing on the 6th (Wed) to allow time to travel to Sao Luis.

Things to do in Maraba

Museums · Outdoors
Highlights from your trip

Sao Luis, Brazil

— 2 nights

City of Tiles

Located on the island of Ilha Upaon-Acu, state capital Sao Luis represents the largest city in Maranhao.
Start off your visit on the 6th (Wed): make a trip to Praca do Pescador.

To see photos, ratings, other places to visit, and tourist information, go to the Sao Luis trip builder website.

The Route module can help you plan travel from Maraba to Sao Luis. Expect a daytime high around 36°C in April, and nighttime lows around 28°C. Finish your sightseeing early on the 8th (Fri) so you can fly to Fortaleza.

Things to do in Sao Luis

Historic Sites · Parks · Museums · Outdoors

Fortaleza, Brazil

— 3 nights

Brazilian Miami

They don't call Fortaleza "Brazilian Miami" for nothing.
Kick off your visit on the 8th (Fri): pause for some serene contemplation at Capela Sao Pedro. Here are some ideas for day two: pause for some serene contemplation at Santuario Nossa Senhora de Fatima, then tour the pleasant surroundings at Praia de Cumbuco, then see the interesting displays at Museum of Industry, and finally kick back and relax at Praia do Futuro.

To find where to stay, maps, photos, and tourist information, read our Fortaleza road trip site.

Getting from Sao Luis to Fortaleza by flight takes about 3 hours. Other options: drive; or take a bus. Expect a daytime high around 35°C in April, and nighttime lows around 28°C. Finish your sightseeing early on the 11th (Mon) to allow enough time to fly to Natal.

Things to do in Fortaleza

Parks · Outdoors · Beaches · Historic Sites

Side Trip

Natal, Brazil

— 2 nights

City of the Sun

The promise of sun, sand, and surf generates plenty of tourism in Natal.
Start off your visit on the 11th (Mon): stroll through Ponta Negra Beach and then examine the collection at Cowboy's Museum. On the 12th (Tue), you'll have a packed day of sightseeing: stroll around Parque das Dunas, see the interesting displays at Museu Camara Cascudo, visit a coastal fixture at Reis Magos Fortress, then tour the pleasant surroundings at Morro do Careca, and finally kick back and relax at Genipabu Beach.

To find traveler tips, ratings, other places to visit, and more tourist information, go to the Natal online trip itinerary maker.

Fly from Fortaleza to Natal in 2.5 hours. Alternatively, you can drive; or take a bus. April in Natal sees daily highs of 36°C and lows of 28°C at night. Finish your sightseeing early on the 13th (Wed) to allow enough time to fly to Porto de Galinhas.

Things to do in Natal

Parks · Outdoors · Beaches · Museums

Side Trip

Porto de Galinhas, Brazil

— 2 nights

Hawaii of the Atlantic

You're in for a treat on your beach holiday to Porto de Galinha.
On the 13th (Wed), examine the collection at Museu das Tartarugas - ONG Ecoassociados, view the masterpieces at So Arte, contemplate the waterfront views at Piscinas Naturais de Porto de Galinhas, then kick back and relax at Cupe beach, then stroll through Muro Alto Beach, and finally sample the fine beverages at Cachacaria e Pimentaria Tio Gilson. Here are some ideas for day two: view the masterpieces at Atelie Gilberto Carcara, enjoy the sand and surf at Vila de Porto de Galinhas Beach, kick back and relax at Praia De Maracaipe, pause for some serene contemplation at Capela Nossa Senhora do Desterro, then admire the striking features of Massangana Sugar Cane Mill, and finally sample the fine beverages at Cachakaria Destak.

Make your Porto de Galinhas itinerary with Inspirock to find out what to see and where to go.

You can fly from Natal to Porto de Galinhas in 2.5 hours. Alternatively, you can drive; or do a combination of bus and taxi. In April, daily temperatures in Porto de Galinhas can reach 34°C, while at night they dip to 28°C. Wrap up your sightseeing on the 15th (Fri) early enough to fly to Salvador.

Things to do in Porto de Galinhas

Parks · Outdoors · Beaches · Museums

Side Trips

Salvador, Brazil

— 1 night

Black Rome

Nowhere are the traditions of Brazil's African-background community as strong as in Salvador, the colorful, historical capital of Bahia state.
On the 15th (Fri), kick back and relax at Praia do Porto da Barra and then kick back and relax at Praia Farol da Barra.

For maps, ratings, other places to visit, and tourist information, refer to the Salvador travel route planner.

Traveling by flight from Porto de Galinhas to Salvador takes 3.5 hours. Alternatively, you can drive; or take a bus. In April, plan for daily highs up to 34°C, and evening lows to 28°C. Finish your sightseeing early on the 16th (Sat) to allow enough time to travel to Guanambi.

Things to do in Salvador

Parks · Outdoors · Beaches

Guanambi, Brazil

— 1 night
Kick off your visit on the 16th (Sat): take an in-depth tour of Memorial Casa de Dona Dede.

Make your Guanambi itinerary with Inspirock to find out what to see and where to go.

Traveling by car from Salvador to Guanambi takes 9.5 hours. Alternatively, you can fly. The time zone difference moving from Brasilia Standard Time (BRT) to Amazon Standard Time (AMT) is minus 1 hour. Finish up your sightseeing early on the 17th (Sun) so you can travel to Brasilia.

Things to do in Guanambi

Museums
Highlights from your trip

Brasilia, Brazil

— 2 nights

Capital of Hope

Although it lacks the cultural flair of Rio de Janeiro and the massive urban sprawl of Sao Paulo, Brasilia holds a fascinating place in the tapestry of Brazil.
Kick off your visit on the 17th (Sun): get into the urban bustle at Mastro e Pavilhao Nacional.

For more things to do, reviews, and tourist information, go to the Brasilia vacation planning site.

The Route module can help you plan travel from Guanambi to Brasilia. The time zone difference when traveling from Guanambi to Brasilia is 1 hour. In April, plan for daily highs up to 32°C, and evening lows to 20°C. Wrap up your sightseeing on the 19th (Tue) early enough to fly to Belo Horizonte.

Things to do in Brasilia

Historic Sites · Parks · Nature · Shopping

Belo Horizonte, Brazil

— 1 night

Garden City

Named for its spectacular mountain views, and known locally as the "Garden City," Belo Horizonte has historically fostered a connection with nature since its inauguration in 1897.
On the 19th (Tue), contemplate in the serene atmosphere at Igreja Sao Jose, browse the exhibits of Palacio das Artes, and then pause for some serene contemplation at Paroquia dos Sagrados Coracoes.

To find photos, traveler tips, maps, and tourist information, read Belo Horizonte day trip planner.

Traveling by flight from Brasilia to Belo Horizonte takes 3 hours. Alternatively, you can drive; or take a bus. In April, daily temperatures in Belo Horizonte can reach 32°C, while at night they dip to 23°C. On the 20th (Wed), you'll travel to Rio de Janeiro.

Things to do in Belo Horizonte

Historic Sites · Shopping · Museums

Rio de Janeiro, Brazil

— 3 nights

Marvelous City

Bustling with samba music and all-night street parties, no city encapsulates the spirit of Brazil better than Rio de Janeiro.
Kick off your visit on the 20th (Wed): explore the historical opulence of Ilha Fiscal. Here are some ideas for day two: engage your brain at Museu do Amanha, admire the natural beauty at Jardim Botânico do Rio de Janeiro, enjoy the sand and surf at Praia de Ipanema, then tour the pleasant surroundings at Pedra do Arpoador, then brush up on your military savvy at Museu Historico do Exercito e Forte de Copacabana, and finally make a trip to Escadaria Selaron.

To see photos, other places to visit, ratings, and other tourist information, read Rio de Janeiro trip website.

Traveling by flight from Belo Horizonte to Rio de Janeiro takes 3 hours. Alternatively, you can drive; or take a bus. In April, plan for daily highs up to 33°C, and evening lows to 26°C. Finish your sightseeing early on the 23rd (Sat) to allow enough time to fly to Sao Paulo.

Things to do in Rio de Janeiro

Parks · Outdoors · Beaches · Museums

Sao Paulo, Brazil

— 3 nights

Land of Drizzle

Don't let the city's nickname--"Land of Drizzle"--dampen your spirits during a trip to Sao Paulo.
Get a sense of the local culture at Paulista Avenue and Pinacoteca do Estado de Sao Paulo. Get some historical perspective at Mosteiro De Sao Bento and São Paulo Cathedral. Change things up with these side-trips from Sao Paulo: Guaruja (Enseada Beach, Tombo Beach, &more). The adventure continues: stroll around Parque Ibirapuera, explore the world behind art at Museu de Arte de Sao Paulo Assis Chateaubriand - MASP, visit Liberdade, and wander the streets of Jardins District.

To see reviews, traveler tips, maps, and other tourist information, read Sao Paulo road trip planner.

Traveling by flight from Rio de Janeiro to Sao Paulo takes 3 hours. Alternatively, you can drive; or take a bus. Expect little chillier temperatures when traveling from Rio de Janeiro in April; daily highs in Sao Paulo reach 30°C and lows reach 20°C. Wrap up your sightseeing on the 26th (Tue) to allow time to fly to Curitiba.

Things to do in Sao Paulo

Parks · Neighborhoods · Outdoors · Beaches

Side Trip

Curitiba, Brazil

— 2 nights

Ecological Capital of Brazil

The word "Brazil" isn't often mentioned in the same breath as "excellent urban planning"--except in Curitiba.
Start off your visit on the 26th (Tue): admire the masterpieces at Museu Oscar Niemeyer, steep yourself in history at Ukranian Memorial, then take a stroll through Bairro de Santa Felicidade, and finally contemplate in the serene atmosphere at Santuario Tabor Magnificat. Here are some ideas for day two: contemplate in the serene atmosphere at Metropolitan Cathedral, then do a tasting at Familia Fardo Vinicola, then take a memorable drive along Estrada Da Graciosa, and finally pause for some serene contemplation at Paróquia São Sebastião.

Find out how to plan Curitiba trip without stress by asking Inspirock to help create an itinerary.

Traveling by flight from Sao Paulo to Curitiba takes 2.5 hours. Alternatively, you can drive; or take a bus. Traveling from Sao Paulo in April, things will get slightly colder in Curitiba: highs are around 26°C and lows about 17°C. Finish up your sightseeing early on the 28th (Thu) so you can travel to Puerto Iguazu.

Things to do in Curitiba

Historic Sites · Museums · Scenic Drive · Outdoors

Side Trip

Puerto Iguazu, Argentina

— 2 nights
The gateway to a national park inscribed on the World Heritage List, growing Puerto Iguazu sits on the confluence of two major rivers near the border with Paraguay and Brazil.
Kick off your visit on the 28th (Thu): stop by Puerto Iguazu, then take in the architecture and atmosphere at Catedral Virgen del Carmen, and then make a trip to Plaza San Martin. Get ready for a full day of sightseeing on the 29th (Fri): take in the dramatic scenery at Iguazu Falls and then make a trip to Triple Frontier.

Inspirock's itinerary builder makes planning a Puerto Iguazu trip simple and quick.

Traveling by combination of flight and bus from Curitiba to Puerto Iguazu takes 3.5 hours. Alternatively, you can drive; or do a combination of bus and car. Traveling from Curitiba in April, expect nights in Puerto Iguazu to be about the same, around 20°C, while days are a bit warmer, around 32°C. Wrap up your sightseeing on the 30th (Sat) early enough to drive to Asuncion.

Things to do in Puerto Iguazu

Parks · Nature · Neighborhoods · Historic Sites

Side Trip

Asuncion, Paraguay

— 3 nights

Mother of Cities

Paraguay's capital and economic center, Asuncion ranks among the youngest cities on the continent, with more than half of its residents under 30 years of age.
On the 1st (Sun), head outdoors with Aventura Xtrema, get outside with Lago Ypacarai, then kick back and relax at Playa De Aregua, and finally head outdoors with Parque Nu Guasu. Here are some ideas for day two: pause for some photo ops at The National Pantheon of Heroes and Oratory of the Virgin Our Lady Saint Mary of the Asuncion, contemplate the long history of Casa de la Independencia, get a sense of history and politics at Palacio de López, then head outdoors with Parque de la Salud, and finally shop like a local with Shopping del Sol.

To find reviews, photos, maps, and other tourist information, go to the Asuncion trip itinerary maker tool.

Drive from Puerto Iguazu to Asuncion in 5 hours. Alternatively, you can do a combination of ferry, bus, and taxi; or do a combination of ferry and bus. The time zone difference when traveling from Puerto Iguazu to Asuncion is minus 1 hour. April in Asuncion sees daily highs of 34°C and lows of 22°C at night. Cap off your sightseeing on the 3rd (Tue) early enough to go by car to Encarnacion.

Things to do in Asuncion

Outdoors · Historic Sites · Parks · Museums

Side Trips

Encarnacion, Paraguay

— 2 nights

Pearl of the South

Encarnacion offers a good selection of cultural and natural attractions.
Kick off your visit on the 3rd (Tue): take in the spiritual surroundings of Iglesia Ortodoxa San Jorge, then appreciate the extensive heritage of Costanera de la Ciudad de Encarnacion Paraguay, and then explore the ancient world of Mision Jesuitica Guarani Jesus de Tavarangue. On the 4th (Wed), you'll have a packed day of sightseeing: kick back and relax at San Jose Beach, explore the ancient world of Ruinas de Jesús, and then steep yourself in history at La Santisima Trinidad De Parana.

To find other places to visit, where to stay, traveler tips, and other tourist information, use the Encarnacion trip itinerary builder app.

Traveling by car from Asuncion to Encarnacion takes 6 hours. Alternatively, you can take a bus. In May in Encarnacion, expect temperatures between 26°C during the day and 16°C at night. Cap off your sightseeing on the 5th (Thu) early enough to travel to Salto.

Things to do in Encarnacion

Historic Sites · Parks · Outdoors · Beaches

Side Trips

Salto, Uruguay

— 2 nights
In a thriving citrus-growing region, Salto allows visitors to explore attractive riverfront areas and admire neatly preserved 19th-century architecture.
Kick off your visit on the 5th (Thu): get engrossed in the history at Museo del Hombre y la Tecnologia and then admire the masterpieces at Museo de Bellas Artes. On the 6th (Fri), you'll have a packed day of sightseeing: head outdoors with Hot Springs of Arapey, learn about winemaking at Bodega Bertolini & Broglio, then get outside with Meseta de Artigas, then take in the spiritual surroundings of Gruta del Padre Pio, and finally relax and rejuvenate at Termas del Dayman.

To see where to stay, more things to do, photos, and tourist information, go to the Salto route maker tool.

Getting from Encarnacion to Salto by car takes about 8 hours. Other options: do a combination of car and flight. The time zone difference when traveling from Encarnacion to Salto is 1 hour. Traveling from Encarnacion in May, you can expect nighttime temperatures to be little chillier in Salto, with lows of 11°C. Finish up your sightseeing early on the 7th (Sat) so you can catch the bus to Montevideo.

Things to do in Salto

Outdoors · Museums · Historic Sites · Spas

Side Trips

Montevideo, Uruguay

— 3 nights
With a rich cultural scene and plenty of developed beaches, Montevideo vacations appeal to a growing number of visitors from around the world.
Museo Municipal de Bellas Artes Juan Manuel Blanes and 1972 Museum will appeal to museum buffs. Get some historical perspective at Catedral de Montevideo and Iglesia San Juan Bautista. Go for a jaunt from Montevideo to Canelones to see Cuchilla alta about 54 minutes away. Next up on the itinerary: wander the streets of Pocitos, head outdoors with Japanese Garden, don't miss a visit to Plaza Independencia, and go for a walk through Rambla de Montevideo.

To find more things to do, traveler tips, photos, and more tourist information, use the Montevideo driving holiday planner.

Traveling by bus from Salto to Montevideo takes 6.5 hours. Alternatively, you can drive. Traveling from Salto in May, expect nights in Montevideo to be about the same, around 11°C, while days are a bit cooler, around 20°C. Finish your sightseeing early on the 10th (Tue) to allow enough time to drive to Colonia del Sacramento.

Things to do in Montevideo

Outdoors · Parks · Neighborhoods · Beaches

Side Trip

Colonia del Sacramento, Uruguay

— 2 nights
Sleepy cobbled streets lined with pastel-colored houses lead down to the water in Colonia del Sacramento.
Start off your visit on the 10th (Tue): make a trip to La Calle de los Suspiros, take an in-depth tour of Museo Portugues, steep yourself in history at Plaza de toros Real de San Carlos, wander the streets of Barrio Historico, then visit a coastal fixture at Colonia del Sacramento Lighthouse, and finally take in the architecture and atmosphere at Basilica De Santisimo Sacramento. Here are some ideas for day two: examine the collection at Museo Casa de Nacarello, see the interesting displays at Museo Cars, examine the collection at Granja Colonia, then pick up a one of a kind souvenir at Antik Objetos con Alma, then take a stroll through Plaza Mayor, and finally view the masterpieces at Casa Carbajal Arte y Objetos.

To see more things to do, maps, other places to visit, and other tourist information, read Colonia del Sacramento trip tool.

You can drive from Montevideo to Colonia del Sacramento in 3 hours. Another option is to take a bus. In May, daytime highs in Colonia del Sacramento are 20°C, while nighttime lows are 13°C. Finish your sightseeing early on the 12th (Thu) to allow enough time to travel to Gualeguaychu.

Things to do in Colonia del Sacramento

Museums · Historic Sites · Neighborhoods · Shopping

Side Trips

Gualeguaychu, Argentina

— 1 night
Sitting on the left bank a Uruguay River tributary, Gualeguaychu was founded in 1783 and serves as a home to over 100,000 people.
Kick off your visit on the 12th (Thu): take a leisurely stroll along Paseo Costanera, see the interesting displays at Instituto Magnasco, enjoy the sand and surf at Balneario Nandubaysal, take in the architecture and atmosphere at Catedral San Jose, then take an in-depth tour of Casa de Haedo Museo, and finally admire the natural beauty at Plaza San Martin.

Plan my Gualeguaychu trip by asking Inspirock to come up with tips and suggestions.

Getting from Colonia del Sacramento to Gualeguaychu by car takes about 3.5 hours. In May, plan for daily highs up to 22°C, and evening lows to 11°C. Finish your sightseeing early on the 13th (Fri) so you can drive back home.

Things to do in Gualeguaychu

Spas · Museums · Parks · Historic Sites