60 days in South America Itinerary

60 days in South America Itinerary

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Route & dates

60 days in South America Itinerary

Start: Charlotte, United States
Fly:  16 h 30 min
1
Asuncion, Paraguay
— 1 day
Drive:  4 h 15 min
2
Encarnacion, Paraguay
— 1 night
Drive + Fly:  2 h 45 min
3
Buenos Aires, Argentina
— 4 nights
Ferry:  1 h
4
Colonia del Sacramento, Uruguay
— 3 nights
Drive:  6 h 45 min
5
Cabo Polonio, Uruguay
— 2 nights
Drive:  1 h 45 min
6
Rocha, Uruguay
— 4 nights
Drive:  1 h 15 min
7
Punta del Este, Uruguay
— 4 nights
Bus:  2 h
8
Montevideo, Uruguay
— 2 nights
Fly:  6 h
9
Ushuaia, Argentina
— 3 nights
Fly:  2 h
10
El Calafate, Argentina
— 4 nights
Fly:  3 h 45 min
11
San Carlos de Bariloche, Argentina
— 4 nights
Drive:  4 h 30 min
12
Puerto Varas, Chile
— 3 nights
Drive:  3 h 30 min
13
Pucon, Chile
— 4 nights
+3
Bus + Foot + Fly + Shuttle:  6 h 45 min
14
Valparaiso, Chile
— 3 nights
Bus:  1 h 15 min
15
Santiago, Chile
— 4 nights
Bus + Fly:  2 h
16
Mendoza, Argentina
— 4 nights
Fly + Shuttle:  6 h 15 min
17
San Pedro de Atacama, Chile
— 4 nights
Shuttle + Fly:  20 h 30 min
End: Charlotte, United States

1
day
Asuncion, Paraguay

Asuncion ©
Paraguay's capital and economic center, Asuncion ranks among the youngest cities on the continent, with more than half of its residents under 30 years of age.
Kick off your visit on the 22nd (Fri): pause for some serene contemplation at Iglesia Maria Auxiliadora, then contemplate the long history of Casa de la Independencia, then admire the masterpieces at Museo Etnografico Andres Barbero, and finally get outside with Parque de la Salud.

To see where to stay, other places to visit, traveler tips, and other tourist information, read Asuncion journey website .

Charlotte, USA to Asuncion is an approximately 16.5-hour flight. You can also do a combination of bus and flight. The time zone changes from Eastern Standard Time to Paraguay Time, which is usually a 1 hour difference. In February, Asuncion is warmer than Charlotte - with highs of 92°F and lows of 73°F. Finish up your sightseeing early on the 22nd (Fri) so you can travel to Encarnacion.

Things to do in Asuncion

Outdoors Historic Sites Museums
Highlights from your plan
Casa de la Independencia ©
Casa de la Independencia
Museo Etnografico Andres Barbero ©
Museo Etnografico Andres Barbero

1
night
Encarnacion, Paraguay

Encarnacion ©
Encarnacion offers a good selection of cultural and natural attractions.
Kick off your visit on the 23rd (Sat): explore the ancient world of Ruinas de Jesús, enjoy the sand and surf at San Jose Beach, and then get to know the fascinating history of Costanera de la Ciudad de Encarnacion Paraguay.

Take the guesswork out of planning a Encarnacion vacation by using our trip itinerary maker.

Take a bus from Asuncion to Encarnacion in 4.5 hours. Alternatively, you can drive. In February, daytime highs in Encarnacion are 90°F, while nighttime lows are 70°F. Finish your sightseeing early on the 23rd (Sat) to allow enough time to travel to Buenos Aires.

Things to do in Encarnacion

Beaches Parks Outdoors
Highlights from your plan
Ruinas de Jesús ©
Ruinas de Jesús
San Jose Beach ©
San Jose Beach

4
nights
Buenos Aires, Argentina

Buenos Aires ©
Cultural capital of South America, Buenos Aires remains one of the largest cities on the continent, serving as a point of departure for exploring the rest of the country.
Deepen your sense of the past at sights like Catedral de la Plata and Plaza de Mayo. Get some cultural insight at Parque 3 de Febrero and Museum of Latin American Art of Buenos Aires. When in Buenos Aires, make a side trip to see Basilica de Lujan in Lujan, approximately 1h 30 min away. The adventure continues: take a stroll through Puerto Madero, appreciate the extensive heritage of San Telmo, shop like a local with Recoleta, and take in the architecture and atmosphere at Basilica del Santisimo Sacramento.

To see maps, photos, and more tourist information, go to the Buenos Aires online trip builder .

You can do a combination of car and flight from Encarnacion to Buenos Aires in 3 hours. Other options are to do a combination of car, flight, and train; or drive. The time zone difference moving from Paraguay Time to Argentine Time is 1 hour. Expect little chillier weather when traveling from Encarnacion in February: highs in Buenos Aires hover around 81°F, while lows dip to 69°F. Finish your sightseeing early on the 27th (Wed) to allow enough time to ride a ferry to Colonia del Sacramento.

Things to do in Buenos Aires

Historic Sites Neighborhoods Shopping

Side Trips

Catedral de la Plata, Basilica de Lujan
Highlights from your plan
Cemiterio de Recoleta ©
Cemiterio de Recoleta
Catedral de la Plata ©
Catedral de la Plata
Basilica del Santisimo Sacramento ©
Basilica del Santisimo Sacramento

3
nights
Colonia del Sacramento, Uruguay

Colonia del Sacramento ©
Sleepy cobbled streets lined with pastel-colored houses lead down to the water in Colonia del Sacramento.
Deepen your sense of the past at sights like Barrio Historico and Plaza Mayor. Satisfy your inner culture vulture at Rio de la Plata and Playa Fomento. The adventure continues: snap pictures at Puerta de la Ciudadela, enjoy the sea views from Colonia del Sacramento Lighthouse, enjoy the sand and surf at Balneario Artilleros, and don't miss a visit to Porton de Campo.

To find photos, maps, ratings, and other tourist information, read our Colonia del Sacramento trip planner .

Traveling by ferry from Buenos Aires to Colonia del Sacramento takes an hour. Alternatively, you can take a bus. In February in Colonia del Sacramento, expect temperatures between 81°F during the day and 67°F at night. Finish up your sightseeing early on the 2nd (Sat) so you can go by car to Cabo Polonio.

Things to do in Colonia del Sacramento

Parks Beaches Outdoors

Side Trips

Antik Objetos con Alma, Playa Santa Ana
Highlights from your plan
Rio de la Plata ©
Rio de la Plata
Basilica De Santisimo Sacramento ©
Basilica De Santisimo Sacramento
Rambla Colonia Del Sacramento ©
Rambla Colonia Del Sacramento

2
nights
Cabo Polonio, Uruguay

Cabo Polonio ©
The isolated hamlet of Cabo Polonio, part of Uruguay's remote Rocha province, offers a different take on a South American beach holiday.
Step off the beaten path and head to Lighthouse of Cabo Polonio and Playa del Rivero. Step out of the city life by going to Beaches at Cabo Polonio and Playa Grande. You'll find plenty of places to visit near Cabo Polonio: Punta del Diablo (Playa de Los Pescadores, Playa de la Viuda, & more). The adventure continues: take in the dramatic natural features at Medanos de la Barra de Valizas.

To see more things to do, maps, and more tourist information, read our Cabo Polonio travel itinerary planner.

Traveling by car from Colonia del Sacramento to Cabo Polonio takes 7 hours. Alternatively, you can take a bus; or do a combination of bus and taxi. The time zone difference when traveling from Colonia del Sacramento to Cabo Polonio is minus 1 hour. Finish your sightseeing early on the 5th (Tue) to allow enough time to drive to Rocha.

Things to do in Cabo Polonio

Parks Beaches Outdoors

Side Trips

Punta del Diablo, Medanos de la Barra de Valizas
Highlights from your plan
Lighthouse of Cabo Polonio ©
Lighthouse of Cabo Polonio
Playa de la Viuda ©
Playa de la Viuda
Playa de Los Pescadores ©
Playa de Los Pescadores

4
nights
Rocha, Uruguay

Rocha ©
Relax on the remote, undeveloped beaches in Rocha, an eastern province of Uruguay noted for its sleepy beachfront towns and pristine nature.
Your cultural itinerary includes sights like Faro Cabo Santa Maria and Fortress of Santa Teresa. Escape the urban bustle at La Pedrera and Playa de Punta del Diablo. Take a break from Rocha with a short trip to Playa Los Botes in La Paloma, about 32 minutes away. Spend the 7th (Thu) exploring nature at Parque Nacional y Reserva de Fauna y Flora El Potrerillo de Santa Teresa. The adventure continues: enjoy the sand and surf at Playa Grande and stroll through Playa La Moza.

For traveler tips, other places to visit, and tourist information, go to the Rocha road trip planning site .

Traveling by car from Cabo Polonio to Rocha takes 2 hours. Alternatively, you can do a combination of taxi and bus; or take a bus. Traveling from Cabo Polonio to Rocha, you'll lose 1 hour due to the time zone difference. In March, plan for daily highs up to 74°F, and evening lows to 65°F. Finish up your sightseeing early on the 9th (Sat) so you can go by car to Punta del Este.

Things to do in Rocha

Parks Beaches Outdoors

Side Trips

La Paloma, La Pedrera
Highlights from your plan
La Pedrera ©
La Pedrera
Faro Cabo Santa Maria ©
Faro Cabo Santa Maria
Fortress of Santa Teresa ©
Fortress of Santa Teresa

4
nights
Punta del Este, Uruguay

Punta del Este ©
With plenty of modern casinos, well-developed beaches, chic restaurants, and upscale hotels, Punta del Este vacations draw visitors from Argentina, Brazil, and beyond.
Do some cultural sightseeing at Ralli Museum and Museo - Taller de Casapueblo. You'll discover tucked-away gems like Playa Brava and Playa de Jose Ignacio. Go for a jaunt from Punta del Este to Piriapolis to see Cerro San Antonio about 48 minutes away. Next up on the itinerary: see the interesting displays at Museo del Mar, enjoy the sand and surf at Playa Punta Ballena, tour the pleasant surroundings at Playa Pinares, and take some stellar pictures from Mirador Punta Ballena.

To see photos, more things to do, other places to visit, and other tourist information, read our Punta del Este trip planner .

Traveling by car from Rocha to Punta del Este takes 1.5 hours. Alternatively, you can take a bus. In March, plan for daily highs up to 74°F, and evening lows to 65°F. Finish your sightseeing early on the 13th (Wed) to allow enough time to drive to Montevideo.

Things to do in Punta del Este

Outdoors Beaches Parks

Side Trips

Maldonado, Jose Ignacio, Cerro San Antonio
Highlights from your plan
Playa de Jose Ignacio ©
Playa de Jose Ignacio
Museo – Taller de Casapueblo ©
Museo – Taller de Casapueblo
Playa Brava ©
Playa Brava

2
nights
Montevideo, Uruguay

Montevideo ©
With a rich cultural scene and plenty of developed beaches, Montevideo vacations appeal to a growing number of visitors from around the world.
Start off your visit on the 14th (Thu): don't miss a visit to Plaza Independencia, see the interesting displays at 1972 Museum, wander the streets of Ciudad Vieja, then explore the historical opulence of Pittamiglio"s Castle, and finally wander the streets of Pocitos. Keep things going the next day: contemplate the waterfront views at Rio De La Plata, then wander the streets of Mundo Pedal, then take a leisurely stroll along Rambla de Montevideo, and finally get the lay of the land with Walking tours.

For where to stay, ratings, maps, and tourist information, use the Montevideo day trip planner .

Getting from Punta del Este to Montevideo by car takes about 2 hours. Other options: take a bus. Plan for slightly colder nights when traveling from Punta del Este in March since evenings lows in Montevideo dip to 59°F. Finish your sightseeing early on the 15th (Fri) to allow enough time to travel to Ushuaia.

Things to do in Montevideo

Neighborhoods Parks Nature
Highlights from your plan
Rambla de Montevideo ©
Rambla de Montevideo
1972 Museum ©
1972 Museum
Castillo Pittamiglio ©
Castillo Pittamiglio

3
nights
Ushuaia, Argentina

Ushuaia ©
Often called the "End of the World" because of its position on the southernmost tip of South America, the expanding city of Ushuaia serves as both a busy commercial port and attractive tourist hub.
Discover out-of-the-way places like Lago Roca and Ushuaia Bay. Get in touch with nature at Mirador de Lagos Escondido y Fagnano and Isla Martillo. There's lots more to do: explore the activities along Laguna Esmeralda, make a trip to Galeria Tematica Historia Fueguina, step off the mainland to explore Isla Bridges, and learn more about the world around you at Acatushun Museum.

To find more things to do, photos, ratings, and other tourist information, go to the Ushuaia online tour planner .

You can fly from Montevideo to Ushuaia in 6 hours. Other options are to do a combination of bus and flight; or do a combination of car and ferry. When traveling from Montevideo in March, plan for cooler days and a bit cooler nights in Ushuaia: temperatures range from 53°F by day to 41°F at night. Wrap up your sightseeing on the 19th (Tue) to allow time to travel to El Calafate.

Things to do in Ushuaia

Parks Nature Outdoors

Side Trip

Lago Roca
Highlights from your plan
Laguna Esmeralda ©
Laguna Esmeralda
Cerro Castor (Castor Mount) ©
Cerro Castor (Castor Mount)
Ushuaia Bay ©
Ushuaia Bay

4
nights
El Calafate, Argentina

El Calafate ©
El Calafate tourism thrives mostly thanks to the city's proximity to a World Heritage-listed national park, famed for containing over 40 large glaciers.
Get outdoors at Kayaking & Canoeing and Estacionamiento Pasarelas Glaciar Perito Moreno. You'll explore the less-touristy side of things at Safari Experience - Patagonia Profunda and Santa Teresita del Nino Jesus. When in El Calafate, make a side trip to see Perito Moreno Glacier in Los Glaciares National Park, approximately 1h 40 min away. Spend the 20th (Wed) exploring nature at Parque Nacional Los Glaciares.

To see traveler tips, photos, more things to do, and other tourist information, use the El Calafate holiday planning website .

You can fly from Ushuaia to El Calafate in 2 hours. Alternatively, you can do a combination of car and ferry; or take a bus. Traveling from Ushuaia in March, you can expect nighttime temperatures to be a bit warmer in El Calafate, with lows of 53°F. Cap off your sightseeing on the 23rd (Sat) early enough to travel to San Carlos de Bariloche.

Things to do in El Calafate

Parks Nature Tours

Side Trip

Perito Moreno National Park
Highlights from your plan
Parque Nacional Los Glaciares ©
Parque Nacional Los Glaciares
Perito Moreno National Park ©
Perito Moreno National Park

4
nights
San Carlos de Bariloche, Argentina

San Carlos de Bariloche ©
Nestled against the foothills of the Andes, scenic San Carlos de Bariloche hugs the southern shore of Nahuel Huapi Lake and ranks among Argentina's top destinations for active outdoor vacations.
Explore hidden gems such as Kayaking & Canoeing and Puerto Blest y Cascada de los Cantaro. Escape the urban bustle at River Rafting & Tubing and Scuba & Snorkeling. When in San Carlos de Bariloche, make a side trip to see Rio Correntoso in Villa La Angostura, approximately 1h 30 min away. Spend the 26th (Tue) exploring nature at San Carlos de Baraloche to Puerto Varas. There's lots more to do: cast your line with a fishing tour, stop by VanWynsberghe Chocolats, take in panoramic vistas at Parque Nacional Nahuel Huapi, and delve into the lush surroundings at Sendero de los Arrayanes.

To see more things to do, maps, other places to visit, and other tourist information, use the San Carlos de Bariloche itinerary maker .

Getting from El Calafate to San Carlos de Bariloche by flight takes about 4 hours. Other options: take a bus; or drive. While traveling from El Calafate, expect a bit warmer days and slightly colder nights in San Carlos de Bariloche, ranging from highs of 68°F to lows of 40°F. Wrap up your sightseeing on the 27th (Wed) early enough to drive to Puerto Varas.

Things to do in San Carlos de Bariloche

Wildlife Parks Nature

Side Trip

Rio Correntoso
Highlights from your plan
Rio Correntoso ©
Rio Correntoso
Fishing Charters & Tours
Puerto Blest y Cascada de los Cantaro ©

3
nights
Puerto Varas, Chile

Puerto Varas ©
Overlooking a lake, with a conical volcano looming in the background, Puerto Varas enjoys memorable scenery but retains its authentic atmosphere.
Deepen your sense of the past at sights like Iglesia Sagrado Corazon de Jesus and Casa Yunge. Get a sense of the local culture at Museo Pablo Fierro and Galeria Sur Vivo. Spend the 29th (Fri) exploring nature at Parque Nacional Vicente Perez Rosales. On the 30th (Sat), spend an adventurous day with a kayaking and canoeing tour. The adventure continues: contemplate the geological forces at Volcan Osorno.

To find where to stay, photos, more things to do, and tourist information, you can read our Puerto Varas vacation maker site .

Traveling by car from San Carlos de Bariloche to Puerto Varas takes 4.5 hours. Alternatively, you can take a bus; or take a bus. Due to the time zone difference, you'll gain 1 hour traveling from San Carlos de Bariloche to Puerto Varas. In March, daytime highs in Puerto Varas are 64°F, while nighttime lows are 45°F. Cap off your sightseeing on the 30th (Sat) early enough to go by car to Pucon.

Things to do in Puerto Varas

Parks Nature Wildlife

Side Trip

Volcan Osorno
Highlights from your plan
Volcan Osorno ©
Volcan Osorno
Parque Nacional Vicente Perez Rosales ©
Iglesia Sagrado Corazon de Jesus ©
Iglesia Sagrado Corazon de Jesus

4
nights
Pucon, Chile

Pucon ©
Nestled in the shadow of the snow-capped Villarrica volcano, Pucon ranks among the world's premier destinations for adventure sports and high-thrills activities.
Visiting Huerquehue National Park and Ojos del Caburga will get you outdoors. You'll discover tucked-away gems like Termas Geometricas and Saltos del Huilo-Huilo. Venture out of the city with trips to Sendero el Puma (in Neltume), Salto Nina Encantada (in Panguipulli) and Fortin Mapuche (in Conaripe). And it doesn't end there: contemplate the waterfront views at Lake Caburga, glide through the air with a parasailing or paragliding tour, and don't miss a visit to Plaza de Armas de Pucon.

To see ratings, reviews, and tourist information, read our Pucon online sightseeing planner .

Getting from Puerto Varas to Pucon by car takes about 3.5 hours. Other options: take a bus. Cap off your sightseeing on the 3rd (Wed) early enough to travel to Valparaiso.

Things to do in Pucon

Parks Nature Outdoors

Side Trips

Neltume, Salto Nina Encantada, Fortin Mapuche
Highlights from your plan
Termas Geometricas ©
Termas Geometricas
Huerquehue National Park ©
Huerquehue National Park
Saltos del Huilo-Huilo ©
Saltos del Huilo-Huilo

3
nights
Valparaiso, Chile

Valparaiso ©
Navigating through a maze of colorful streets winding up and down steep hills remains an integral part of any Valparaiso tour.
Satisfy your inner culture vulture at Casa de Isla Negra and La Sebastiana. Popular historic sites such as Paseo Gervasoni and Iglesia Las Mercedes are in your itinerary. Change things up with these side-trips from Valparaiso: Playa Los Molles (in La Ligua), Concon Dunes (in Concon) and Playa Punta De Tralca (in El Quisco). And it doesn't end there: enjoy the sand and surf at Reñaca, stroll through Playa Tunquen, enjoy the scholastic atmosphere at Universidad Tecnica Federico Santa Maria, and take an in-depth tour of Villa Victoria.

To find reviews, more things to do, ratings, and tourist information, read Valparaiso online road trip planner .

You can do a combination of bus, flight, and shuttle from Pucon to Valparaiso in 7 hours. Other options are to drive; or take a bus. In April, plan for daily highs up to 67°F, and evening lows to 53°F. Finish your sightseeing early on the 7th (Sun) so you can drive to Santiago.

Things to do in Valparaiso

Parks Beaches Outdoors

Side Trips

Reñaca, Concon Dunes, Casa de Isla Negra, Playa Punta De Tralca, Iglesia Las Mercedes
Highlights from your plan
Reñaca ©
Reñaca
Concon Dunes ©
Concon Dunes
Casa de Isla Negra ©
Casa de Isla Negra

4
nights
Santiago, Chile

Santiago ©
Santiago tourism thrives largely thanks to the city's big selection of cultural and entertainment options, including museums, theaters, restaurants, bars, and giant malls.
Do some cultural sightseeing at La Chascona and Centro Cultural Palacio de la Moneda y Plaza de la Ciudadania. Take a break from the city and head to San Cristóbal Hill and Parque Nacional Pali Aike. Go for a jaunt from Santiago to San Jose de Maipo to see River Rafting & Tubing about 1h 05 min away. Next up on the itinerary: make a trip to Cerro Santa Lucia, pause for some serene contemplation at Santuario de la Inmaculada Concepcion, explore the world behind art at Museo Chileno de Arte Precolombino, and admire the striking features of Metropolitan Cathedral (Catedral Metropolitana).

For ratings, more things to do, photos, and tourist information, you can read our Santiago day trip planning website .

Getting from Valparaiso to Santiago by car takes about 1.5 hours. Other options: take a bus. Finish your sightseeing early on the 11th (Thu) so you can travel to Mendoza.

Things to do in Santiago

Parks Nature Museums

Side Trips

Pali Aike National Park, River Rafting & Tubing
Highlights from your plan

4
nights
Mendoza, Argentina

Mendoza ©
Famed for its neat vineyards and thriving wine production, Mendoza remains the place to visit for a pleasant combination of relaxation and recreation.
Get outdoors at River Rafting & Tubing and La Quebrada del Condor-Day Trip. Step off the beaten path and head to Pulenta Estate Winery and Bodega Ruca Malen. Change things up with these side-trips from Mendoza: El Camino de las 365 Curvas (in Las Heras) and Maipu (Carinae Vinedos & Bodega & Casa El Enemigo). And it doesn't end there: learn about winemaking at Bodega La Azul, take in the architecture and atmosphere at Nuestra Senora del Perpetuo Socorro, and see the sights as you ascend with a climbing tour.

To see other places to visit, photos, maps, and more tourist information, you can read our Mendoza trip itinerary website .

You can do a combination of bus and flight from Santiago to Mendoza in 2 hours. Other options are to drive; or take a bus. The time zone changes from Chile Time to Argentine Time, which is usually a 1 hour difference. In April, daily temperatures in Mendoza can reach 73°F, while at night they dip to 53°F. Wrap up your sightseeing on the 15th (Mon) early enough to travel to San Pedro de Atacama.

Things to do in Mendoza

Wineries Outdoors Tours

Side Trips

Maipu, El Camino de las 365 Curvas, La Quebrada del Condor-Day Trip, Santuario Virgen de Lourdes
Highlights from your plan
Bodega Roberto Bonfanti ©
Bodega Roberto Bonfanti
El Camino de las 365 Curvas ©
El Camino de las 365 Curvas
River Rafting & Tubing

4
nights
San Pedro de Atacama, Chile

San Pedro de Atacama ©
Major archeological sites and a renowned museum remain the big draws in San Pedro de Atacama tourism, appealing to visitors interested in learning more about South America's pre-Columbian cultures.
Step out of the city life by going to Piedras Rojas and Salar de Tara. Eschew the tourist crowds and head to Tebinquinche Lake and Nature & Wildlife Tours. There's still lots to do: witness a stunning natural landmark at Termas Banos de Puritama, admire nature's extreme beauty at Atacama Desert, explore the activities along Laguna Chaxa, and examine the collection at Museo del Meteorito.

To find ratings, maps, more things to do, and more tourist information, use the San Pedro de Atacama trip site .

Do a combination of flight and shuttle from Mendoza to San Pedro de Atacama in 6.5 hours. Alternatively, you can drive; or take a bus. Traveling from Mendoza to San Pedro de Atacama, you'll gain 1 hour due to the time zone difference. Expect a bit cooler evenings in San Pedro de Atacama when traveling from Mendoza in April, with lows around 39°F. On the 20th (Sat), wrap the sightseeing up by early afternoon so you can travel back home.

Things to do in San Pedro de Atacama

Parks Wildlife Nature

Side Trip

Atacama Desert
Highlights from your plan
Salar de Tara ©
Salar de Tara
Valle Arcoiris ©
Valle Arcoiris
Piedras Rojas ©
Piedras Rojas

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