52 days in South America, Central America, Mexico & United States Itinerary

52 days in South America, Central America, Mexico & United States Itinerary

Created using Inspirock trip itinerary planner

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1
Santiago, Chile
— 6 nights
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Buenos Aires, Argentina
— 5 nights
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Cusco, Peru
— 2 nights
Bus to Ollantaytambo, Train to Machu Picchu
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Machu Picchu, Peru
— 1 night
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Guayaquil, Ecuador
— 3 nights
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Panama City, Panama
— 3 nights
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Mexico City, Mexico
— 14 nights
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Miami, United States
— 15 nights
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Santiago, Chile

— 6 nights

City of the Island Hills

Santiago tourism thrives largely thanks to the city's big selection of cultural and entertainment options, including museums, theaters, restaurants, bars, and giant malls.
La Chascona and Barrio Bellavista are good opportunities to explore the local culture. You'll visit kid-friendly attractions like Valle Nevado - Ski Resort Chile and Museo Interactivo Mirador. There's still lots to do: take your sightseeing to a higher altitude at San Cristóbal Hill, admire the landmark architecture of Metropolitan Cathedral (Catedral Metropolitana), browse the exhibits of Chilean National Museum of Fine Arts, and take in the pleasant sights at Plaza de Armas.

For ratings, where to stay, reviews, and tourist information, read Santiago journey maker app.

Guayaquil, Ecuador to Santiago is an approximately 8.5-hour flight. You can also drive; or take a bus. You'll lose 1 hour traveling from Guayaquil to Santiago due to the time zone difference. Wrap up your sightseeing on the 8th (Fri) to allow time to fly to Buenos Aires.

Things to do in Santiago

Museums · Neighborhoods · Parks · Winter Sports

Side Trip

Buenos Aires, Argentina

— 5 nights

Queen of La Plata

Cultural capital of South America, Buenos Aires remains one of the largest cities on the continent, serving as a point of departure for exploring the rest of the country.
Cemiterio de Recoleta and Plaza de Mayo will appeal to history buffs. Attractions like Puerto Madero and Parque 3 de Febrero make great kid-friendly stops. And it doesn't end there: explore the world behind art at Museo Nacional de Bellas Artes, take a stroll through Recoleta, admire the landmark architecture of El Ateneo Grand Splendid, and take in the architecture and atmosphere at Catedral Primada.

To see maps, where to stay, traveler tips, and other tourist information, use the Buenos Aires trip itinerary planner.

Fly from Santiago to Buenos Aires in 5.5 hours. Alternatively, you can drive; or take a bus. Due to the time zone difference, you'll lose 1 hour traveling from Santiago to Buenos Aires. In July in Buenos Aires, expect temperatures between 17°C during the day and 10°C at night. Finish your sightseeing early on the 13th (Wed) so you can fly to Cusco.

Things to do in Buenos Aires

Historic Sites · Museums · Neighborhoods · Shopping

Cusco, Peru

— 2 nights

Imperial City

Capital of the Inca Empire for three centuries, World Heritage-listed Cusco is now a major tourist destination, drawing nearly 2 million annual tourists with its well-preserved colonial architecture and proximity to Machu Picchu.
Start off your visit on the 14th (Thu): take in the spiritual surroundings of Qorikancha, then contemplate the long history of Plaza de Armas, and then take an in-depth tour of Museo Inka. On the next day, wander the streets of San Blas, then trek along exploor, then take in the spiritual surroundings of Museo de Vida Monastica - Monasterio de Santa Catalina del Cusco, and finally admire the striking features of Centro Historico De Cusco.

To find traveler tips, maps, ratings, and tourist information, refer to the Cusco trip itinerary builder tool.

Traveling by flight from Buenos Aires to Cusco takes 10 hours. Alternatively, you can drive; or take a bus. You'll gain 2 hours traveling from Buenos Aires to Cusco due to the time zone difference. While traveling from Buenos Aires, expect a bit warmer days and slightly colder nights in Cusco, ranging from highs of 24°C to lows of 1°C. Wrap up your sightseeing on the 15th (Fri) to allow time to travel to Machu Picchu.

Things to do in Cusco

Historic Sites · Neighborhoods · Museums · Outdoors

Machu Picchu, Peru

— 1 night
A symbol of the Incan civilization, the abandoned city of Machu Picchu represents a must-see on a Peru vacation.
To find where to stay, photos, ratings, and other tourist information, go to the Machu Picchu online day trip planner.

Traveling by combination of bus and train from Cusco to Machu Picchu takes 4 hours. Alternatively, you can take a train; or drive. On the 16th (Sat), you're off to Guayaquil.

Things to do in Machu Picchu

Historic Sites · Spas · Parks · Tours

Guayaquil, Ecuador

— 3 nights

Pearl of the Pacific

Hills dotted with colorful houses and waterfront promenades typify Guayaquil, Ecuador's largest city and commercial center.
Let the collections at Presley Norton Museum and Museum of Anthropology and Contemporary Art capture your imagination. Visit Guayaquil Historical Park and El Faro de Guayaquil for their historical value. The adventure continues: wander the streets of Las Penas, stop by Cerro Santa Ana, take an in-depth tour of Museo en Miniatura Guayaquil en la Historia, and take in nature's colorful creations at Parque Seminario.

To find photos, reviews, maps, and tourist information, you can read our Guayaquil online attractions planner.

You can fly from Machu Picchu to Guayaquil in 8 hours. Alternatively, you can drive; or do a combination of car and bus. In July, daytime highs in Guayaquil are 34°C, while nighttime lows are 25°C. Wrap up your sightseeing on the 20th (Wed) early enough to fly to Panama City.

Things to do in Guayaquil

Historic Sites · Museums · Neighborhoods · Parks

Panama City, Panama

— 3 nights

Dubai of Latin America

Arguably the most modern of Central American cities, Panama City boasts a shimmering skyline of glass skyscrapers.
Museo del Canal Interoceanico de Panama and Biomuseo will appeal to museum buffs. Your inner history buff will appreciate Casco Viejo and Iglesia de San José. It doesn't end there: explore the striking landscape of Soberania National Park and don't miss a visit to Amador Causeway (Calzada de Amador).

To see more things to do, traveler tips, other places to visit, and tourist information, go to the Panama City online tour itinerary planner.

Fly from Guayaquil to Panama City in 6 hours. Traveling from Guayaquil in July, plan for somewhat warmer nights in Panama City, with lows around 29°C. Wrap up your sightseeing on the 23rd (Sat) early enough to fly to Mexico City.

Things to do in Panama City

Parks · Nature · Historic Sites · Neighborhoods

Mexico City, Mexico

— 14 nights

City of Palaces

Breathtakingly large, Mexico City provides a home for almost 9 million people living in nearly 1,700 distinct neighborhoods.
You'll explore and learn at Museo Nacional de Antropologia and Museo Frida Kahlo. Deepen your sense of the past at sights like Zona Arqueológica de Teotihuacan Estacionamiento Puerta 5 and Museo del Templo Mayor. Venture out of the city with trips to Catedral de Texcoco -La Inmaculada Concepcion (in Texcoco) and Museo Del Barro (in Metepec). There's still lots to do: admire the masterpieces at Palacio de Bellas Artes, take in the spiritual surroundings of Metropolitan Cathedral (Catedral Metropolitana), take a peaceful walk through Bosque de Chapultepec, and ponder the world of politics at National Palace (Palacio Nacional).

To see where to stay, other places to visit, maps, and more tourist information, use the Mexico City road trip app.

You can fly from Panama City to Mexico City in 7 hours. Other options are to drive; or do a combination of bus and shuttle. Traveling from Panama City to Mexico City, you'll gain 1 hour due to the time zone difference. When traveling from Panama City in July, plan for slightly colder days in Mexico City, with highs around 27°C, while nights are much colder with lows around 15°C. Cap off your sightseeing on the 6th (Sat) early enough to catch the flight to Miami.

Things to do in Mexico City

Museums · Historic Sites · Neighborhoods · Tours

Side Trips

Miami, United States

— 15 nights

Magic City

Florida’s mecca of fun in the sun, the lively tropical metropolis of Miami is one of the world’s top vacation spots.
You'll visit kid-friendly attractions like South Beach and Scuba & Snorkeling. Your inner history buff will appreciate Lincoln Road and St Patrick Catholic Church. Change things up with these side-trips from Miami: Everglades National Park (Anhinga Trail, Gumbo Limbo Trail, &more), Florida Keys Wild Bird Rehabilitation Center (in Tavernier) and John Pennekamp Coral Reef State Park (in Key Largo). The adventure continues: get to know the fascinating history of Art Deco Historic District, examine the collection at Vizcaya Museum and Gardens, observe the fascinating underwater world at Miami Seaquarium, and enjoy the sand and surf at Fort Lauderdale Beach.

Use Inspirock's suggestions to plan your Miami trip and find the best activities and attractions for your vacation.

You can fly from Mexico City to Miami in 6.5 hours. Other options are to drive; or take a bus. You'll lose 1 hour traveling from Mexico City to Miami due to the time zone difference. Expect a bit warmer weather when traveling from Mexico City in August: highs in Miami hover around 38°C, while lows dip to 30°C. Finish your sightseeing early on the 21st (Sun) so you can fly back home.

Things to do in Miami

Parks · Museums · Shopping · Outdoors

Side Trips

Chile travel guide

4.3
Landmarks · Parks · Specialty Museums
Land of Poets
Squeezed between the Andes and the Pacific Ocean, geographically diverse Chile is a long, thin stretch of land encompassing some of the world's driest deserts in the north, and some of its largest glacial fields in the south. Though most Chile holidays include some form of adventure in the vast wilderness areas, the country also contains charming cities providing plenty of urban things to do and see. Many tours of Chile include at least a brief visit to the country's lush wine regions, where backyard vineyards compete with sprawling estates producing some of the world's most respected whites and reds.

Ecuador travel guide

4.5
Landmarks · Sacred & Religious Sites · History Museums
With abundant opportunities to discover fascinating World Heritage Sites, a holiday in Ecuador remains among the most culturally enriching travel experiences. Home to the world's highest active volcano, this little country packs a big punch when it comes to tourist activities. Some of the most popular things to do in Ecuador include visits to its astonishingly biodiverse wilderness areas, home to some 1,500 bird species, 840 species of amphibians and reptiles, and nearly 20,000 plant species. Of course, the highlight of many Ecuador vacations is bound to be the Galapagos Islands, made famous by naturalist Charles Darwin. Aside from the stunning nature, Ecuador also boasts many historic cities filled with photogenic colonial-era churches, mansions, and plazas.

Mexico travel guide

4.5
Ruins · Beaches · Landmarks
Tailor-made for anyone seeking that traditional sun-and-sand experience, Mexico vacations allow visitors to explore nearly 10,000 km (6,200 mi) of picturesque coastlines. Idyllic beaches and favorable year-round weather aside, this diverse country with a rich pre-Colombian history allows tourists a chance to discover a fascinating cuisine, numerous archaeological sites, state-of-the-art museums, colonial-era haciendas, and outstanding examples of 21st-century architecture. Most visitors get to know the country by its cities, but if you want a well-rounded Mexico tour, spend some time exploring its jungles, cloud forests, Caribbean reefs, snowcapped volcanoes, vast deserts, and tranquil lagoons. Life is lived outdoors in Mexico, so wherever you go, don't forget to dine alfresco and stroll the country's colonial streets.

United States travel guide

4.5
Specialty Museums · Beaches · History Museums
More than the country of car-packed streets seen in TV shows and movies, the United States of America is a complex and diverse home to over 300 million people living in a wide range of landscapes and climates. From its big-city skyscrapers to its sprawling natural parks, the country's ''melting pot'' combines many ethnic groups that share a strong sense of national identity despite their cultural differences. A country of road trips and big blue skies, the United States harbors orderly cities filled with restaurants, parks, museums, and innumerable sightseeing opportunities, as well as pristine natural areas perfect for a holiday in the great outdoors. To see as much as you can of this diverse land quickly, drive over some of the more than 6 million km (4 million mi) of highways leading through deserts, mountain peaks, fertile fields, and giant urban centers.