50 days in South America Itinerary

50 days in South America Itinerary

Created using Inspirock South America trip planner

Travel Warning: Security Concerns   More Info
This plan was created by another user. Make it your plan

Route & dates

50 days in South America Itinerary

Start: Playa del Carmen, Mexico
Fly:  11​h 45​min
1
Lima, Peru
— 1 night
Fly:  4​h 30​min
2
Mendoza, Argentina
— 5 nights
Fly:  3​h 30​min
3
Buenos Aires, Argentina
— 2 nights
Fly:  5​h 15​min
4
Ushuaia, Argentina
— 5 nights
Fly:  7​h 30​min
5
San Carlos de Bariloche, Argentina
— 5 nights
Fly + Shuttle:  9​h 45​min
6
Valparaiso, Chile
— 4 nights
+2
Shuttle + Fly + Shuttle:  6​h 30​min
7
San Pedro de Atacama, Chile
— 5 nights
Drive:  11​h 15​min
8
Uyuni, Bolivia
— 1 night
Taxi + Fly:  5​h 15​min
9
Sucre, Bolivia
— 2 nights
Fly:  2​h 45​min
10
La Paz, Bolivia
— 2 nights
Fly:  3​h 45​min
11
Arequipa, Peru
— 3 nights
Fly:  1​h 15​min
12
Cusco, Peru
— 6 nights
Fly:  9​h 30​min
End: Playa del Carmen, Mexico

1
night
Lima, Peru

Lima ©
Founded in 1535 by Spanish explorer Francisco Pizarro, Lima represents an interesting blend of modern attractions and preserved colonial architecture, much of it clustered in the World Heritage-listed city center.
On the 15th (Tue), wander the streets of Barranco, appreciate the extensive heritage of Huaycan de Cieneguilla, then take in the architecture and atmosphere at Cathedral of Lima, and finally steep yourself in history at Monastery of Santo Domingo (Iglesia y Monasterio de Santo Domingo). Keep things going the next day: take a leisurely stroll along Miraflores Boardwalk, then explore the ancient world of Huaca Pucllana, then pause for some serene contemplation at Iglesia y Convento de San Francisco, and finally wander the streets of Centro Historico de Lima.

To see traveler tips, photos, more things to do, and tourist information, you can read our Lima day trip website .

Playa del Carmen, Mexico to Lima is an approximately 12-hour flight. Prepare for slightly colder weather when traveling from Playa del Carmen in October: high temperatures in Lima hover around 24°C and lows are around 19°C. Wrap up your sightseeing on the 16th (Wed) early enough to travel to Mendoza.

Things to do in Lima

Historic Sites Neighborhoods
Highlights from your plan
Huaycan de Cieneguilla ©
Huaycan de Cieneguilla
Cathedral of Lima ©
Cathedral of Lima

5
nights
Mendoza, Argentina

Mendoza ©
Famed for its neat vineyards and thriving wine production, Mendoza remains the place to visit for a pleasant combination of relaxation and recreation.
Do some cultural sightseeing at Pulenta Estate Winery and Bodega Chandon. Step off the beaten path and head to Bodega La Azul and Bodega Ruca Malen. You'll find plenty of places to visit near Mendoza: Vista Flores (Bodega Piedra Negra (Lurton) & Bodega Monteviejo), Los Sauces (SOLOCONTIGO Wine & Bodega Corazon del Sol) and Maipu (Casa El Enemigo & Carinae Vinedos & Bodega). On the 21st (Mon), give your taste buds a day to remember with a local gastronomic tour. Next up on the itinerary: do a tasting at Bodega Catena Zapata and pause for some serene contemplation at Santuario Virgen de Lourdes.

To find more things to do, traveler tips, other places to visit, and more tourist information, go to the Mendoza travel planning site .

Traveling by flight from Lima to Mendoza takes 4.5 hours. Alternatively, you can drive; or take a bus. The time zone difference when traveling from Lima to Mendoza is 2 hours. Expect a bit warmer weather when traveling from Lima in October: highs in Mendoza hover around 28°C, while lows dip to 13°C. Wrap up your sightseeing on the 22nd (Tue) to allow time to travel to Buenos Aires.

Things to do in Mendoza

Wineries Tours Nature

Side Trips

Maipu, Los Sauces, Vista Flores, Santuario Virgen de Lourdes, Laureano Gomez Winemaker
Highlights from your plan
Bodega Roberto Bonfanti ©
Bodega Roberto Bonfanti
Bodega Tierras Altas ©
Bodega Tierras Altas
Pulenta Estate Winery ©
Pulenta Estate Winery

2
nights
Buenos Aires, Argentina

Buenos Aires ©
Cultural capital of South America, Buenos Aires remains one of the largest cities on the continent, serving as a point of departure for exploring the rest of the country.
Start off your visit on the 23rd (Wed): admire all the interesting features of Estadio Alberto J. Armando (La Bombonera), see the interesting displays at Fragata ARA Sarmiento, take in the views from Puente de la Mujer, pause for some serene contemplation at Catedral Metropolitana, then pause for some serene contemplation at Basilica del Santisimo Sacramento, and finally wander the streets of Palermo Soho. On the next day, take in the architecture and atmosphere at Basilica Maria Auxiliadora y San Carlos, then take in the architecture and atmosphere at Catedral de San Isidro, then head outdoors with Delta El Tigre, and finally pause for some photo ops at Floralis Generica.

To see where to stay, ratings, reviews, and tourist information, use the Buenos Aires trip itinerary website .

Getting from Mendoza to Buenos Aires by flight takes about 3.5 hours. Other options: drive; or take a bus. When traveling from Mendoza in October, plan for a bit cooler days and about the same nights in Buenos Aires: temperatures range from 24°C by day to 17°C at night. Wrap up your sightseeing on the 24th (Thu) early enough to travel to Ushuaia.

Things to do in Buenos Aires

Historic Sites Nature Parks

Side Trips

Catedral de San Isidro, Delta El Tigre
Highlights from your plan
Catedral de San Isidro ©
Catedral de San Isidro
Basilica del Santisimo Sacramento ©
Basilica del Santisimo Sacramento
Basilica Maria Auxiliadora y San Carlos ©

5
nights
Ushuaia, Argentina

Often called the "End of the World" because of its position on the southernmost tip of South America, the expanding city of Ushuaia serves as both a busy commercial port and attractive tourist hub.
Step out of the city life by going to Nature & Wildlife Tours and Cerro Castor (Castor Mount). You'll discover tucked-away gems like Lago Roca and Ushuaia Bay. Spend the 30th (Wed) exploring nature at Senda Pampa Alta. There's lots more to do: explore the activities along Laguna Esmeralda, pause for some photo ops at Monumento Antiguos Pobladores de Ushuaia, trek along Glacier Martial, and look for all kinds of wild species at Cerro Alarken Nature Reserve.

Before you visit Ushuaia, use our trip planner to discover what you can do and see there.

You can fly from Buenos Aires to Ushuaia in 5.5 hours. Alternatively, you can do a combination of car and ferry; or take a bus. Expect a bit cooler weather when traveling from Buenos Aires in October: highs in Ushuaia hover around 11°C, while lows dip to 3°C. Wrap up your sightseeing on the 30th (Wed) early enough to travel to San Carlos de Bariloche.

Things to do in Ushuaia

Parks Outdoors Nature

Side Trip

Lago Roca
Highlights from your plan
Nature & Wildlife Tours
Cerro Castor (Castor Mount) ©
Cerro Castor (Castor Mount)
Lago Roca ©
Lago Roca

5
nights
San Carlos de Bariloche, Argentina

Nestled against the foothills of the Andes, scenic San Carlos de Bariloche hugs the southern shore of Nahuel Huapi Lake and ranks among Argentina's top destinations for active outdoor vacations.
Get in touch with nature at Puerto Blest y Cascada de los Cantaro and Piedras Blancas. Get some historical perspective at Parroquia San Eduardo and Catedral de San Carlos de Bariloche. Explore San Carlos de Bariloche's surroundings by going to Rio Correntoso (in Villa La Angostura) and Mirador Lago Traful (in Villa Traful). And it doesn't end there: get outside with Outdoor Activities, get a new perspective on things with Boat Tours & Water Sports, get some fabulous bargains at Chocolate Patagonico, and see the interesting displays at Museo del Lago Gutierrez.

To see traveler tips, other places to visit, maps, and other tourist information, use the San Carlos de Bariloche day trip app .

Traveling by flight from Ushuaia to San Carlos de Bariloche takes 7.5 hours. Alternatively, you can do a combination of car and ferry; or take a bus. Traveling from Ushuaia in October, expect nights in San Carlos de Bariloche to be about the same, around 1°C, while days are a bit warmer, around 17°C. Cap off your sightseeing on the 5th (Tue) early enough to travel to Valparaiso.

Things to do in San Carlos de Bariloche

Outdoors Parks Wildlife

Side Trips

Mirador Lago Traful, Rio Correntoso
Highlights from your plan
Fishing Charters & Tours
Parroquia San Eduardo ©
Parroquia San Eduardo
Puerto Blest y Cascada de los Cantaro ©

4
nights
Valparaiso, Chile

Valparaiso ©
Navigating through a maze of colorful streets winding up and down steep hills remains an integral part of any Valparaiso tour.
Eschew the tourist crowds and head to Reñaca and Playa Los Molles. You'll get in some beach time at La Rambla and Playa Tunquen. Get out of town with these interesting Valparaiso side-trips: Canopy El Canelo (in Algarrobo), Vina Casa Marin Winery (in Lo Abarca) and Vina Casas del Bosque (in Casablanca). There's lots more to do: see the interesting displays at Casa de Isla Negra, get to know the fascinating history of Paseo Gervasoni, make a trip to Cerro Concepcion, and tour the pleasant surroundings at Playa La Laguna.

To find other places to visit, photos, more things to do, and tourist information, go to the Valparaiso day trip planning app .

You can do a combination of flight and shuttle from San Carlos de Bariloche to Valparaiso in 10 hours. Other options are to do a combination of bus, flight, and shuttle; or drive. The time zone difference when traveling from San Carlos de Bariloche to Valparaiso is minus 1 hour. Expect a bit warmer evenings in Valparaiso when traveling from San Carlos de Bariloche in November, with lows around 15°C. Wrap up your sightseeing on the 10th (Sun) early enough to travel to San Pedro de Atacama.

Things to do in Valparaiso

Outdoors Beaches Parks

Side Trips

Zapallar, Playa Tunquen, Reñaca, Playa Los Molles, Casa Marin Winery
Highlights from your plan
Playa de Zapallar ©
Playa de Zapallar
Vina Casas del Bosque ©
Vina Casas del Bosque
Paseo Gervasoni ©
Paseo Gervasoni

5
nights
San Pedro de Atacama, Chile

San Pedro de Atacama ©
Major archeological sites and a renowned museum remain the big draws in San Pedro de Atacama tourism, appealing to visitors interested in learning more about South America's pre-Columbian cultures.
Get a sense of the local culture at Pukara de Quitor and Museo del Meteorito. You'll explore the less-touristy side of things at Nature & Wildlife Tours and Piedras Rojas. Spend the 13th (Wed) exploring nature at Reserva Nacional de Flamencos. There's lots more to do: witness a stunning natural landmark at Termas Banos de Puritama, admire the verdant scenery at Valle de Catarpe, explore the activities along Tebinquinche Lake, and get lost in a book at Libreria Del Desierto.

To plan San Pedro de Atacama vacation without wasting time, ask Inspirock to design an itinerary.

You can do a combination of shuttle and flight from Valparaiso to San Pedro de Atacama in 6.5 hours. Other options are to do a combination of shuttle, flight, and bus; or drive. When traveling from Valparaiso in November, plan for somewhat warmer days and a bit cooler nights in San Pedro de Atacama: temperatures range from 28°C by day to 3°C at night. Finish up your sightseeing early on the 16th (Sat) so you can travel to Uyuni.

Things to do in San Pedro de Atacama

Parks Nature Wildlife

Side Trip

Atacama Desert
Highlights from your plan
Valle Arcoiris ©
Valle Arcoiris
Atacama Desert ©
Atacama Desert
Nature & Wildlife Tours

1
night
Uyuni, Bolivia

Uyuni ©
Emptiness surrounds the desert outpost of Uyuni, the gateway to the world's largest salt flats.
On the 17th (Sun), contemplate the geological forces at Tunupa Volcano. Keep things going the next day: step off the mainland to explore Isla Incahuasi and then explore the striking landscape at Salar de Uyuni.

To see traveler tips, other places to visit, maps, and other tourist information, read Uyuni visit planning site .

Traveling by combination of bus and car from San Pedro de Atacama to Uyuni takes 11.5 hours. Alternatively, you can drive; or do a combination of bus, car, and train. When traveling from San Pedro de Atacama in November, plan for colder days and somewhat warmer nights in Uyuni: temperatures range from 12°C by day to 11°C at night. Wrap up your sightseeing on the 18th (Mon) early enough to travel to Sucre.

Things to do in Uyuni

Nature Parks
Highlights from your plan
Isla Incahuasi ©
Isla Incahuasi
Tunupa Volcano ©
Tunupa Volcano
Salar de Uyuni ©
Salar de Uyuni

2
nights
Sucre, Bolivia

Sucre ©
The constitutional capital of Bolivia, Sucre has a well-preserved historic center, with many buildings dating back to the city's founding in the 16th century.
Get some historical perspective at Santa Clara Convent and Basilica de San Francisco. Do some cultural sightseeing at House of Liberty Museum - Casa de la Libertad and Plaza 25 de Mayo. There's still lots to do: head outdoors with La Maja, take in the architecture and atmosphere at Iglesia Nuestra Senora de La Merced, view the masterpieces at Arte y Cultura Sucre Galeria, and make a trip to Centro Cultural Masis.

To see reviews, traveler tips, maps, and more tourist information, read Sucre trip builder site .

Do a combination of taxi and flight from Uyuni to Sucre in 5.5 hours. Alternatively, you can drive; or do a combination of taxi and bus. When traveling from Uyuni in November, plan for much warmer days in Sucre, with highs around 26°C, while nights are about the same with lows around 11°C. Wrap up your sightseeing on the 21st (Thu) to allow time to travel to La Paz.

Things to do in Sucre

Historic Sites Museums Outdoors
Highlights from your plan
Santa Clara Convent ©
Santa Clara Convent
General Cemetery ©
General Cemetery
Museo del Tesoro ©
Museo del Tesoro

2
nights
La Paz, Bolivia

La Paz ©
Take a moment to catch your breath as you commence your holiday in La Paz.
On the 22nd (Fri), take a memorable drive along WMDR Yungas Road. Get ready for a full day of sightseeing on the 23rd (Sat): get the adrenaline pumping with an extreme tour, take in the spiritual surroundings of Iglesia de San Francisco, then make a trip to Mi Teleferico, and finally enjoy some diversion at Urban Rush Bolivia.

To see photos, ratings, and more tourist information, refer to the La Paz trip planner.

You can fly from Sucre to La Paz in 3 hours. Alternatively, you can drive; or take a bus. Prepare for little chillier weather when traveling from Sucre in November: high temperatures in La Paz hover around 20°C and lows are around 2°C. Wrap up your sightseeing on the 23rd (Sat) early enough to travel to Arequipa.

Things to do in La Paz

Outdoors Scenic Drive Tours
Highlights from your plan
WMDR Yungas Road ©
WMDR Yungas Road
Iglesia de San Francisco ©
Iglesia de San Francisco
Adrenaline & Extreme Tours

3
nights
Arequipa, Peru

Arequipa ©
In an area dominated three imposing volcanoes, Arequipa vacations allow visitors to admire well-preserved colonial architecture in a dramatic setting.
Eschew the tourist crowds and head to Historic Centre of Arequipa and Yanahuara. Cathedral of Arequipa Museum and Iglesia Santo Domingo will appeal to history buffs. There's still lots to do: take an in-depth tour of Museo Santuarios Andinos, head outdoors with Canon de Cotahuasi, see the interesting displays at Museo de Arte Virreinal Santa Teresa, and take in the spiritual surroundings of Iglesia de San Miguel Arcangel.

To find more things to do, reviews, and more tourist information, read Arequipa road trip planning app .

Fly from La Paz to Arequipa in 4 hours. Alternatively, you can drive; or do a combination of bus and flight. The time zone difference moving from Bolivia Time (BOT) to Peru Time (PET) is minus 1 hour. In November, Arequipa is somewhat warmer than La Paz - with highs of 24°C and lows of 11°C. Wrap up your sightseeing on the 26th (Tue) early enough to travel to Cusco.

Things to do in Arequipa

Museums Historic Sites Outdoors
Highlights from your plan
Museo de la Catedral de Arequipa ©
Museo de la Catedral de Arequipa
Iglesia de la Compania de Jesus ©
Iglesia de la Compania de Jesus

6
nights
Cusco, Peru

Capital of the Inca Empire for three centuries, World Heritage-listed Cusco is now a major tourist destination, drawing nearly 2 million annual tourists with its well-preserved colonial architecture and proximity to Machu Picchu.
You'll discover tucked-away gems like Sacred Valley of the Incas and Horseback Riding Tours. Do some cultural sightseeing at Spas & Wellness and River Rafting & Tubing. Venture out of the city with trips to San Pedro Apostol de Andahuaylillas (in Andahuaylillas) and Moray (in Maras). There's lots more to do: steep yourself in history at Tipon, admire the masterpieces at Museo Maximo Laura, take in the local highlights with Walking tours, and admire the striking features of The Company of Jesus Church.

To see other places to visit, where to stay, more things to do, and more tourist information, you can read our Cusco trip planner .

Traveling by flight from Arequipa to Cusco takes 1.5 hours. Alternatively, you can drive; or take a bus. In November in Cusco, expect temperatures between 26°C during the day and 8°C at night. Wrap up your sightseeing by early afternoon on the 2nd (Mon) to allow time for travel back home.

Things to do in Cusco

Tours Historic Sites Outdoors

Side Trips

Sacred Valley of the Incas, Pinkuylluna Mountain Granaries, San Pedro Apostol de Andahuaylillas, Moray
Highlights from your plan
Spas & Wellness
Moray ©
Moray
Pinkuylluna Mountain Granaries ©
Pinkuylluna Mountain Granaries

Similar Plans

53 days in Caribbean, Mexico, Central America & South America BY A USER FROM UNITED KINGDOM November, popular sights PREFERENCES: November ATTRACTION STYLE: Popular sights PACE: Medium 60 days in South America BY A USER FROM AUSTRALIA November, culture, popular & hidden gems PREFERENCES: November, culture ATTRACTION STYLE: Popular & hidden gems PACE: Medium 54 days in Chile BY A USER FROM CHILE March, outdoors, popular sights PREFERENCES: March, outdoors ATTRACTION STYLE: Popular sights PACE: Medium 60 days in South America, Central America, Mexico & Caribbean BY A USER FROM EGYPT February, teens, fast-paced, popular sights PREFERENCES: February, teens ATTRACTION STYLE: Popular sights PACE: Fast-paced 57 days in South America BY A USER FROM SPAIN October, popular sights PREFERENCES: October ATTRACTION STYLE: Popular sights PACE: Medium 60 days in Caribbean, Mexico & South America BY A USER FROM ISRAEL April, popular sights PREFERENCES: April ATTRACTION STYLE: Popular sights PACE: Medium 58 days in Mexico, Central America & South America BY A USER FROM NETHERLANDS August, culture, historic sites, museums, wildlife, fast-paced, popular sights PREFERENCES: August, culture, historic sites, museums, wildlife ATTRACTION STYLE: Popular sights PACE: Fast-paced 60 days in South America, Central America, Mexico & United States BY A USER FROM NETHERLANDS August, culture, historic sites, museums, wildlife, fast-paced, popular sights PREFERENCES: August, culture, historic sites, museums, wildlife ATTRACTION STYLE: Popular sights PACE: Fast-paced 60 days in Africa, South Pacific, South America, Mexico & Europe BY A USER FROM ISRAEL February, popular sights PREFERENCES: February ATTRACTION STYLE: Popular sights PACE: Medium 60 days in South America & Caribbean BY A USER FROM AUSTRALIA February, slow & easy, popular sights PREFERENCES: February ATTRACTION STYLE: Popular sights PACE: Slow & easy 60 days in Argentina BY A USER FROM ARGENTINA February, popular & hidden gems PREFERENCES: February ATTRACTION STYLE: Popular & hidden gems PACE: Medium 40 days in Argentina BY A USER FROM INDONESIA January, popular sights PREFERENCES: January ATTRACTION STYLE: Popular sights PACE: Medium
View more plans