50 days in Mexico & Panama City Itinerary

50 days in Mexico & Panama City Itinerary

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Route & dates

50 days in Mexico & Panama City Itinerary

Start: Jerusalem, Israel
Fly:  19 h
1
Cancun, Mexico
— 7 nights
Drive:  2 h 15 min
2
Chichen Itza, Mexico
— 2 nights
Drive:  2 h
3
Tulum, Mexico
— 8 nights
Drive:  2 h 30 min
4
Cozumel, Mexico
— 7 nights
Fly:  4 h 15 min
5
Mexico City, Mexico
— 7 nights
Fly:  3 h 15 min
6
Puerto Vallarta, Mexico
— 7 nights
Fly:  5 h 45 min
7
Cabo San Lucas, Mexico
— 6 nights
Fly:  19 h
8
Panama City, Panama
— 3 nights
Fly:  21 h 30 min
End: Jerusalem, Israel


Learn more about your trip

7
nights
Cancun, Mexico

Few destinations in Mexico dazzle visitors quite like Cancun, a modern resort town filled with glitzy hotels sitting on picturesque and well-developed Caribbean beaches.
You'll discover tucked-away gems like National Reef Park of Puerto Morelos and Spas. Escape the urban bustle at Shark Diving and Canyoning & Rappelling Tours. Step out of Cancun with an excursion to Punta Sur in Isla Mujeres--about 1h 20 min away. There's much more to do: pause for some serene contemplation at Parroquia de Cristo Resucitado, fulfill a lifelong dream with a swim-with-the-dolphins experience, shop like a local with Kukulcan Plaza, and see the interesting displays at Mayan Museum of Cancun.

To find maps, more things to do, and more tourist information, read our Cancun trip itinerary maker site .

Jerusalem, Israel to Cancun is an approximately 19-hour combination of bus and flight. You'll gain 7 hours traveling from Jerusalem to Cancun due to the time zone difference. Prepare for somewhat warmer weather when traveling from Jerusalem in November: high temperatures in Cancun hover around 33°C and lows are around 24°C. Cap off your sightseeing on the 9th (Sat) early enough to go by car to Chichen Itza.

Things to do in Cancun

Outdoors Tours Wildlife

Side Trips

Kukulcan Plaza, Punta Sur, National Reef Park of Puerto Morelos
Highlights from your plan
Shark Diving
National Reef Park of Puerto Morelos ©
Punta Sur ©
Punta Sur

2
nights
Chichen Itza, Mexico

Chichen Itza
Featuring the largest archeological site of the ancient Mayan civilization, Chichen Itza remains one of the most visited tourist destinations in Mexico.
On the 10th (Sun), explore the ancient world of Plataforma de Venus, explore the ancient world of Chichen Itza, then delve into the distant past at The Ossuary, and finally delve into the distant past at Temple of the Bearded Man. Get ready for a full day of sightseeing on the next day: explore the world behind art at Casa de los Venados, identify plant and animal life at Xkopek Parque Apicola, and then explore the ancient world of Ek Balam.

For other places to visit, more things to do, ratings, and more tourist information, read our Chichen Itza online trip planner .

Traveling by car from Cancun to Chichen Itza takes 2.5 hours. Alternatively, you can take a shuttle; or take a bus. Traveling from Cancun in November, plan for a bit warmer nights in Chichen Itza, with lows around 29°C. Finish your sightseeing early on the 12th (Tue) so you can drive to Tulum.

Things to do in Chichen Itza

Historic Sites Museums Parks

Side Trips

Valladolid, Izamal, Ek Balam
Highlights from your plan
Ek Balam
Ek Balam
Convento de San Antonio de Padua ©
Convento de San Antonio de Padua
Chichen Itza ©
Chichen Itza

8
nights
Tulum, Mexico

Tulum ©
The only Mayan site built to overlook the ocean, Tulum remains a coastal paradise preserving the last vestiges of a pre-Hispanic civilization.
Eschew the tourist crowds and head to Shark Diving and Mayan Beach. Museum-lovers will appreciate Tulum Art Club and MiNiAtUrE art Gallery. Explore Tulum's surroundings by going to Cobá Zona Arqueológica Cobá (in Coba), Sian Ka'an Biosphere Reserve (in Sian Ka'an) and Playa del Carmen (Scuba & Snorkeling, Spas, & more). There's lots more to do: look for all kinds of wild species at LabnaHa Cenotes & Eco Park, take in the exciting artwork at Balam Art On Feathers, delve into the distant past at Las Pinturas, and admire the striking features of IK Lab.

To find ratings, traveler tips, where to stay, and more tourist information, use the Tulum road trip planning tool .

Drive from Chichen Itza to Tulum in 2 hours. Alternatively, you can take a shuttle; or take a bus. Traveling from Chichen Itza in November, plan for little chillier nights in Tulum, with lows around 24°C. Finish up your sightseeing early on the 20th (Wed) so you can go by car to Cozumel.

Things to do in Tulum

Outdoors Wildlife Parks

Side Trips

Playa del Carmen, Sian Ka'an Biosphere Reserve, Cobá Zona Arqueológica Cobá
Highlights from your plan
Tulum Archaeological Site ©
Tulum Archaeological Site
Shark Diving
LabnaHa Cenotes & Eco Park ©
LabnaHa Cenotes & Eco Park

7
nights
Cozumel, Mexico

Cozumel ©
Thanks to the island's outstanding scuba diving and snorkeling options, Cozumel tourism sector remains a major employer and the main source of income for this Caribbean getaway.
Step off the beaten path and head to Columbia Reef and Palancar Reef. Step out of the city life by going to Santa Rosa Wall and Paradise Beach Cozumel. There's lots more to do: get interesting insight from Tours, delve into the distant past at San Gervasio Mayan Archaeological Site, examine the collection at The Mayan Cacao Company, and kick back and relax at Punta Sur Eco Beach Park.

To see more things to do, where to stay, maps, and more tourist information, read our Cozumel holiday planner.

You can drive from Tulum to Cozumel in 2.5 hours. In November, plan for daily highs up to 32°C, and evening lows to 24°C. Cap off your sightseeing on the 27th (Wed) early enough to travel to Mexico City.

Things to do in Cozumel

Wildlife Outdoors Parks
Highlights from your plan
Santa Rosa Wall ©
Santa Rosa Wall
Palancar Reef ©
Palancar Reef
Columbia Reef ©
Columbia Reef

7
nights
Mexico City, Mexico

Mexico City ©
Breathtakingly large, Mexico City provides a home for almost 9 million people living in nearly 1,700 distinct neighborhoods.
Get some historical perspective at Historic Center (Centro Historico) and Museo del Templo Mayor. Zona Arqueológica de Teotihuacan Estacionamiento Puerta 5 and Museo Nacional de Antropologia are good opportunities to explore the local culture. Step out of Mexico City with an excursion to Robert Brady Museum in Cuernavaca--about 1h 20 min away. Next up on the itinerary: contemplate the long history of Basilica de Santa Maria de Guadalupe, examine the collection at Museo del Tiempo Tlalpan, admire the striking features of National Palace (Palacio Nacional), and don't miss a visit to Paseo de la Reforma.

To see ratings, where to stay, maps, and more tourist information, use the Mexico City trip itinerary maker website .

Traveling by flight from Cozumel to Mexico City takes 4.5 hours. Alternatively, you can do a combination of ferry and bus. The time zone difference moving from Eastern Standard Time to Central Standard Time is minus 1 hour. While traveling from Cozumel, expect slightly colder days and much colder nights in Mexico City, ranging from highs of 26°C to lows of 11°C. Cap off your sightseeing on the 4th (Wed) early enough to travel to Puerto Vallarta.

Things to do in Mexico City

Historic Sites Museums Neighborhoods

Side Trips

Robert Brady Museum, Zona Arqueológica de Teotihuacan Estacionamiento Puerta 5
Highlights from your plan
Historic Center (Centro Historico) ©
Historic Center (Centro Historico)
Chapultepec Castle ©
Chapultepec Castle

7
nights
Puerto Vallarta, Mexico

Puerto Vallarta ©
Boasting a coastline made for perfectly framed photographs of romantic sunsets, Puerto Vallarta continuously ranks among the world's top tourist resorts.
Shop till you drop at Peyote People and The Loft Galeria. Get a sense of the local culture at Old Vallarta and Bucerias Art Gallery. Explore Puerto Vallarta's surroundings by going to Dolphin & Whale Watching (in Sayulita), A Broken Art (in Bucerias) and Playa Las Animas (in Cabo Corrientes). And it doesn't end there: surround yourself with nature on a nature and wildlife tour, take a tour by water with Boat Tours & Water Sports, get a taste of the local shopping with Abdallahy 4D, and kick your exploration up a notch at some of the top local zipline courses and adventure parks.

To see photos, where to stay, other places to visit, and more tourist information, refer to the Puerto Vallarta trip itinerary maker app .

Fly from Mexico City to Puerto Vallarta in 3.5 hours. Alternatively, you can do a combination of bus and flight; or drive. Traveling from Mexico City in December, expect Puerto Vallarta to be somewhat warmer, temps between 32°C and 22°C. Cap off your sightseeing on the 11th (Wed) early enough to travel to Cabo San Lucas.

Things to do in Puerto Vallarta

Outdoors Tours Wildlife

Side Trips

Bucerias, Nuevo Vallarta Beach, Marietas Islands, Playa Las Animas
Highlights from your plan
Nuevo Vallarta Beach ©
Nuevo Vallarta Beach
Nature & Wildlife Tours
Playa Las Animas ©
Playa Las Animas

6
nights
Cabo San Lucas, Mexico

Cabo San Lucas ©
One of Mexico's premier vacation spots, Cabo San Lucas lures pleasure seekers with its trendy restaurant scene, raucous nightlife, and, of course, picture-perfect beaches.
Get outdoors at Playa Los Cerritos and Santa Maria Beach. Head to La Turquesa Jewelry and Art and Bill Olverafor plenty of shopping. Explore the numerous day-trip ideas around Cabo San Lucas: Cabo Pulmo Marine Preserve (in Cabo Pulmo), San Jose del Cabo (Parroquia San Jose, Ivan Guaderrama Art Gallery, & more) and Tortugueros Las Playitas (in Todos Santos). There's lots more to do: meet some fierce fish with a shark diving experience, contemplate the waterfront views at Bay of Cabo San Lucas, cast your line with a fishing tour, and see the interesting displays at Museo de Historia Natural.

For other places to visit, photos, ratings, and more tourist information, read Cabo San Lucas trip planner.

Traveling by flight from Puerto Vallarta to Cabo San Lucas takes 6 hours. Alternatively, you can do a combination of flight and bus; or drive. Due to the time zone difference, you'll gain 1 hour traveling from Puerto Vallarta to Cabo San Lucas. When traveling from Puerto Vallarta in December, plan for slightly colder days in Cabo San Lucas, with highs around 29°C, while nights are about the same with lows around 21°C. Wrap up your sightseeing on the 17th (Tue) early enough to travel to Panama City.

Things to do in Cabo San Lucas

Outdoors Wildlife Parks

Side Trips

San Jose del Cabo, Todos Santos, Cabo Pulmo Marine Preserve
Highlights from your plan
Santa Maria Beach ©
Santa Maria Beach
Shark Diving
Playa Los Cerritos ©
Playa Los Cerritos

3
nights
Panama City, Panama

Panama City ©
Arguably the most modern of Central American cities, Panama City boasts a shimmering skyline of glass skyscrapers.
Get outdoors at Panama Rainforest Discovery Center and Isla Santa Catalina. Museum-lovers will get to explore Museo del Canal Interoceanico de Panama and Weil Art Gallery. The adventure continues: get to know the fascinating history of Casco Viejo, pause for some serene contemplation at Iglesia de la Merced, and take in the spiritual surroundings of Bahai Temple.

To see maps, more things to do, traveler tips, and other tourist information, refer to the Panama City trip tool .

Explore your travel options from Cabo San Lucas to Panama City with the Route module. Due to the time zone difference, you'll lose 2 hours traveling from Cabo San Lucas to Panama City. Expect somewhat warmer temperatures when traveling from Cabo San Lucas in December; daily highs in Panama City reach 36°C and lows reach 28°C. On the 21st (Sat), wrap the sightseeing up by early afternoon so you can travel back home.

Things to do in Panama City

Parks Historic Sites Neighborhoods

Side Trips

Isla Santa Catalina, Panama Rainforest Discovery Center
Highlights from your plan
Panama Rainforest Discovery Center ©
Panama Rainforest Discovery Center
Casco Viejo ©
Casco Viejo
Museo del Canal Interoceanico de Panama ©

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