50 days in Central America & South America Itinerary

50 days in Central America & South America Itinerary

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Route & dates

50 days in Central America & South America Itinerary

Start: Guatemala City, Guatemala
Drive:  2 h 45 min
1
Santa Ana, El Salvador
— 2 nights
Drive:  1 h 45 min
2
Suchitoto, El Salvador
— 1 night
Drive:  1 h 15 min
3
San Salvador, El Salvador
— 6 nights
Fly:  5 h 15 min
4
Lima, Peru
— 5 nights
Fly:  7 h 15 min
5
Foz do Iguacu, Brazil
— 2 nights
Fly + Bus:  5 h 15 min
6
Gramado, Brazil
— 4 nights
Bus + Fly:  5 h
7
Rio de Janeiro, Brazil
— 6 nights
Fly + Bus:  1 h 30 min
8
Sao Paulo, Brazil
— 5 nights
Fly:  11 h
9
Arequipa, Peru
— 2 nights
+4
Fly + Taxi + Bus + Foot + Train:  13 h
10
Machu Picchu, Peru
— 1 night
+2
Train + Foot + Bus:  3 h 15 min
11
Cusco, Peru
— 6 nights
Fly + Shuttle:  11 h 15 min
12
Granada, Nicaragua
— 2 nights
Drive:  1 h 45 min
13
San Juan del Sur, Nicaragua
— 1 night
Drive:  3 h 15 min
14
Leon, Nicaragua
— 3 nights
Bus + Fly:  5 h 15 min
End: Guatemala City, Guatemala

2
nights
Santa Ana, El Salvador

Santa Ana ©
Santa Ana is the second largest city in El Salvador, located 64 kilometers northwest of San Salvador, the capital city. Change things up with these side-trips from Santa Ana: El Imposible National Park (in Ahuachapan) and Axul (in Concepcion de Ataco). There's more to do: get impressive views of Izalco Volcano and explore the activities along Lake Coatepeque.

To find reviews, photos, where to stay, and other tourist information, you can read our Santa Ana day trip site .

Guatemala City, Guatemala to Santa Ana is an approximately 3-hour car ride. You can also take a bus; or do a combination of flight and bus. Traveling from Guatemala City in October, things will get a bit warmer in Santa Ana: highs are around 34°C and lows about 24°C. Finish your sightseeing early on the 1st (Fri) to allow enough time to drive to Suchitoto.

Things to do in Santa Ana

Parks Nature Shopping

Side Trips

Axul, El Imposible National Park, Lake Coatepeque
Highlights from your plan
El Imposible National Park ©
El Imposible National Park
Izalco Volcano ©
Izalco Volcano
Lake Coatepeque ©
Lake Coatepeque

1
night
Suchitoto, El Salvador

Suchitoto ©
A small colonial municipality in Cuscatlan, El Salvador.Suchitoto is a municipality in the Department of Cuscatlán, El Salvador that has seen continuous human habitation long before Spanish colonization. Kick off your visit on the 2nd (Sat): explore the activities along Lago Suchitlán, then get outside with Parque Central Suchitoto, and then take in the spiritual surroundings of Iglesia Santa Lucia.

To see reviews, more things to do, maps, and other tourist information, refer to the Suchitoto trip planning site .

Traveling by car from Santa Ana to Suchitoto takes 2 hours. Alternatively, you can take a bus. In November, daily temperatures in Suchitoto can reach 35°C, while at night they dip to 22°C. Finish your sightseeing early on the 2nd (Sat) to allow enough time to drive to San Salvador.

Things to do in Suchitoto

Outdoors Historic Sites Parks
Highlights from your plan
Parque Central Suchitoto ©
Parque Central Suchitoto
Lago Suchitlán ©
Lago Suchitlán
Iglesia Santa Lucia ©
Iglesia Santa Lucia

6
nights
San Salvador, El Salvador

San Salvador ©
The country's capital, San Salvador sits in a scenic position surrounded by impressive volcanoes.
San Salvador is known for historic sites, nature, museums, parks, and nightlife. Your plan includes some of its best attractions: look for all kinds of wild species at Cinquera Rain Forest Park, steep yourself in history at Hospital Divina Providencia Chapel, pause for some serene contemplation at Iglesia El Rosario, and see some colorful creatures with a scuba or snorkeling tour.

To find more things to do, ratings, photos, and other tourist information, read San Salvador day trip planning tool .

Traveling by car from Suchitoto to San Salvador takes 1.5 hours. Alternatively, you can take a bus. November in San Salvador sees daily highs of 35°C and lows of 22°C at night. Wrap up your sightseeing on the 8th (Fri) early enough to travel to Lima.

Things to do in San Salvador

Museums Historic Sites Wildlife
Highlights from your plan
Cinquera Rain Forest Park ©
Cinquera Rain Forest Park
Iglesia El Rosario ©
Iglesia El Rosario

5
nights
Lima, Peru

Lima ©
Founded in 1535 by Spanish explorer Francisco Pizarro, Lima represents an interesting blend of modern attractions and preserved colonial architecture, much of it clustered in the World Heritage-listed city center.
Lima is known for parks, historic sites, museums, shopping, and nightlife. Your plan includes some of its best attractions: ponder the design of Plaza de Armas (Plaza Mayor), pause for some serene contemplation at Iglesia y Convento de San Francisco, shop like a local with Shopping Center Larcomar (Centro Comercial Larcomar), and walk around Circuito Magico Del Agua.

To find reviews, maps, photos, and other tourist information, read our Lima trip builder site .

Getting from San Salvador to Lima by flight takes about 5.5 hours. The time zone changes from Central Standard Time (CST) to Peru Time (PET), which is usually a 1 hour difference. Expect slightly colder weather when traveling from San Salvador in November: highs in Lima hover around 26°C, while lows dip to 20°C. Cap off your sightseeing on the 13th (Wed) early enough to travel to Foz do Iguacu.

Things to do in Lima

Outdoors Museums Historic Sites
Highlights from your plan
Museo Larco ©
Museo Larco
Plaza de Armas (Plaza Mayor) ©
Plaza de Armas (Plaza Mayor)
Huaca Pucllana ©
Huaca Pucllana

2
nights
Foz do Iguacu, Brazil

Foz do Iguacu ©
A gateway to the world-renowned Iguacu Falls, which spectacularly divide Brazil and Argentina, the modern, high-rise city of Foz do Iguacu can't help but play second fiddle to the natural wonder in its vicinity.
Foz do Iguacu is known for nature, zoos & aquariums, historic sites, adventure, and museums. Your plan includes some of its best attractions: admire the sheer force of Iguazu Falls, learn about wildlife with up-close encounters at Parque das Aves Bird Park, admire the engineering at Itaipu Dam, and contemplate in the serene atmosphere at Buddhist Temple.

To find where to stay, maps, reviews, and other tourist information, read our Foz do Iguacu itinerary builder .

Fly from Lima to Foz do Iguacu in 7.5 hours. Alternatively, you can do a combination of flight and bus; or drive. The time zone changes from Peru Time (PET) to Brasilia Time (BRT), which is usually a 2 hour difference. Expect somewhat warmer weather when traveling from Lima in November: highs in Foz do Iguacu hover around 34°C, while lows dip to 22°C. Finish up your sightseeing early on the 16th (Sat) so you can travel to Gramado.

Things to do in Foz do Iguacu

Parks Historic Sites Nature
Highlights from your plan
Iguazu Falls ©
Iguazu Falls
Parque das Aves Bird Park ©
Parque das Aves Bird Park
Itaipu Dam ©
Itaipu Dam

4
nights
Gramado, Brazil

Gramado ©
Surrounded by impressive mountain scenery in the state of Rio Grande do Sul, the small city of Gramado charms visitors with its alpine European-style architecture and blossoming flowers.
You'll find plenty of places to visit near Gramado: Bento Goncalves (Casa Fontanari, Cristofoli Vinhos de Familia, & more) and Enigma Escape Game (in Porto Alegre). And it doesn't end there: contemplate the waterfront views at Black Lake, do a tasting at Casa Seganfredo, immerse yourself in nature at Parque Estadual do Caracol, and take in the architecture and atmosphere at Catedral de Pedra.

To find traveler tips, reviews, other places to visit, and more tourist information, go to the Gramado tour app .

You can do a combination of flight and bus from Foz do Iguacu to Gramado in 5.5 hours. Alternatively, you can do a combination of bus and flight; or drive. Cap off your sightseeing on the 20th (Wed) early enough to travel to Rio de Janeiro.

Things to do in Gramado

Parks Wineries Nature

Side Trips

Bento Goncalves, Canela, Enigma Escape Game
Highlights from your plan
Lago Negro ©
Lago Negro
Mini Mundo ©
Mini Mundo
Casa Fontanari ©
Casa Fontanari

6
nights
Rio de Janeiro, Brazil

Rio de Janeiro ©
Bustling with samba music and all-night street parties, no city encapsulates the spirit of Brazil better than Rio de Janeiro.
Rio de Janeiro is known for beaches, nature, parks, museums, and nightlife. Your plan includes some of its best attractions: take in the awesome beauty at Bondinho Pao de Acucar, enjoy the sand and surf at Barra da Tijuca Beach, pause for some photo ops at Corcovado Christ the Redeemer, and tour the pleasant surroundings at Copacabana Beach.

To see other places to visit, photos, ratings, and more tourist information, you can read our Rio de Janeiro online trip planner .

You can do a combination of bus and flight from Gramado to Rio de Janeiro in 5 hours. Alternatively, you can drive; or take a bus. In November in Rio de Janeiro, expect temperatures between 33°C during the day and 25°C at night. Wrap up your sightseeing on the 26th (Tue) early enough to travel to Sao Paulo.

Things to do in Rio de Janeiro

Parks Outdoors Nature
Highlights from your plan
Corcovado - Christ the Redeemer ©
Corcovado - Christ the Redeemer
Sugarloaf Mountain ©
Sugarloaf Mountain
Copacabana Beach ©
Copacabana Beach

5
nights
Sao Paulo, Brazil

Sao Paulo ©
Don't let the city's nickname--"Land of Drizzle"--dampen your spirits during a trip to Sao Paulo.
Go for a jaunt from Sao Paulo to Aparecida to see National Sanctuary of Our Lady of Aparecida about 1h 55 min away. There's still lots to do: stroll around Parque Ibirapuera, see the interesting displays at Museu da Lingua Portuguesa, explore the world behind art at Museu de Arte de Sao Paulo Assis Chateaubriand - MASP, and shop like a local with Paulista Avenue.

For other places to visit, where to stay, more things to do, and more tourist information, read Sao Paulo travel route builder .

Traveling by combination of flight and bus from Rio de Janeiro to Sao Paulo takes 1.5 hours. Alternatively, you can fly; or drive. Traveling from Rio de Janeiro in November, expect a bit cooler with lows of 21°C in Sao Paulo. Finish your sightseeing early on the 1st (Sun) so you can travel to Arequipa.

Things to do in Sao Paulo

Museums Shopping Fun & Games

Side Trip

National Sanctuary of Our Lady of Aparecida
Highlights from your plan
Pixel Realidade Virtual ©
Pixel Realidade Virtual
Parque Ibirapuera ©
Parque Ibirapuera
Pinacoteca do Estado de Sao Paulo ©
Pinacoteca do Estado de Sao Paulo

2
nights
Arequipa, Peru

Arequipa ©
In an area dominated three imposing volcanoes, Arequipa vacations allow visitors to admire well-preserved colonial architecture in a dramatic setting.
Start off your visit on the 2nd (Mon): take an in-depth tour of Museo Santuarios Andinos, see the interesting displays at Santa Catalina Monastery, and then admire the striking features of Casa del Moral. Here are some ideas for day two: see the interesting displays at Monasterio de la Recoleta, admire the striking features of Plaza de Armas, and then admire the striking features of La Mansion del Fundador.

For photos, traveler tips, where to stay, and other tourist information, read our Arequipa day trip planning app .

Traveling by combination of bus and flight from Sao Paulo to Arequipa takes 11 hours. Alternatively, you can do a combination of bus and flight; or drive. The time zone difference when traveling from Sao Paulo to Arequipa is minus 2 hours. In December, Arequipa is slightly colder than Sao Paulo - with highs of 24°C and lows of 12°C. Finish your sightseeing early on the 3rd (Tue) to allow enough time to travel to Machu Picchu.

Things to do in Arequipa

Museums
Highlights from your plan
Santa Catalina Monastery ©
Santa Catalina Monastery
Plaza de Armas ©
Plaza de Armas
Museo Santuarios Andinos ©
Museo Santuarios Andinos

1
night
Machu Picchu, Peru

Machu Picchu ©
A symbol of the Incan civilization, the abandoned city of Machu Picchu represents a must-see on a Peru vacation.
Kick off your visit on the 4th (Wed): explore the ancient world of Winay Wayna. On your second day here, delve into the distant past at Santuario Historico de Machu Picchu.

To find other places to visit, ratings, traveler tips, and more tourist information, go to the Machu Picchu holiday planner.

You can do a combination of bus and train from Arequipa to Machu Picchu in 13 hours. Alternatively, you can drive; or take a bus. Finish your sightseeing early on the 5th (Thu) to allow enough time to travel to Cusco.

Things to do in Machu Picchu

Historic Sites
Highlights from your plan
Santuario Historico de Machu Picchu ©
Winay Wayna ©
Winay Wayna

6
nights
Cusco, Peru

Cusco ©
Capital of the Inca Empire for three centuries, World Heritage-listed Cusco is now a major tourist destination, drawing nearly 2 million annual tourists with its well-preserved colonial architecture and proximity to Machu Picchu.
You'll find plenty of places to visit near Cusco: Pisac (in Pisac) and Salinas de Maras (in Maras). And it doesn't end there: explore the ancient world of Sacsayhuaman, admire the striking features of Centro Historico De Cusco, explore the world behind art at Museo de Arte Precolombino, and get engrossed in the history at Museo Inka.

For photos, traveler tips, reviews, and tourist information, go to the Cusco planning tool .

Traveling by combination of train and bus from Machu Picchu to Cusco takes 3.5 hours. Alternatively, you can take a train; or drive. In December in Cusco, expect temperatures between 24°C during the day and 9°C at night. Finish your sightseeing early on the 11th (Wed) so you can travel to Granada.

Things to do in Cusco

Historic Sites Outdoors Wildlife

Side Trips

Salinas de Maras, Sacred Valley of the Incas, Pisac
Highlights from your plan
Sacsayhuaman ©
Sacsayhuaman
Sacred Valley of the Incas ©
Sacred Valley of the Incas
Plaza de Armas ©
Plaza de Armas

2
nights
Granada, Nicaragua

Granada ©
The lakeside city of Granada has the look and feel of a historically important economic and political center, with grand colonial architecture, a unified look, and many cultural attractions.
You'll find plenty of places to visit near Granada: Masaya Volcano (in Masaya) and Apoyo (in La Laguna de Apoyo). The adventure continues: pause for some serene contemplation at Iglesia de La Merced, admire the masterpieces at Casa de Los Tres Mundos, see the interesting displays at Centro Cultural Antiguo Convento San Francisco, and stop by Tio Antonio Hamaca.

To see where to stay, more things to do, photos, and other tourist information, refer to the Granada trip planner .

Traveling by combination of flight and shuttle from Cusco to Granada takes 11.5 hours. Alternatively, you can do a combination of flight and bus. The time zone difference when traveling from Cusco to Granada is minus 1 hour. Finish your sightseeing early on the 14th (Sat) to allow enough time to drive to San Juan del Sur.

Things to do in Granada

Parks Nature Museums

Side Trip

Masaya
Highlights from your plan
Masaya Volcano ©
Masaya Volcano
Iglesia de La Merced ©
Iglesia de La Merced
Apoyo
Apoyo

1
night
San Juan del Sur, Nicaragua

San Juan del Sur ©
Set in a crescent-shaped bay, San Juan del Sur has become known as a popular surfing spot and coastal holiday destination for Nicaraguan families and international visitors alike.
On the 15th (Sun), enjoy some diversion at Surf Ranch Skateboard Park, kick back and relax at La Flor Beach Natural Reserve, and then don't miss a visit to Mirador del Cristo de la Misericordia.

Use Inspirock's suggestions to plan your San Juan del Sur trip and find the best activities and attractions for your vacation.

Traveling by car from Granada to San Juan del Sur takes 2 hours. Alternatively, you can do a combination of shuttle and bus; or take a shuttle. Expect a daytime high around 34°C in December, and nighttime lows around 28°C. Wrap up your sightseeing on the 15th (Sun) early enough to drive to Leon.

Things to do in San Juan del Sur

Outdoors Parks Wildlife
Highlights from your plan
La Flor Beach Natural Reserve ©
La Flor Beach Natural Reserve
Mirador del Cristo de la Misericordia ©

3
nights
Leon, Nicaragua

Leon ©
A cultured and storied city, Leon attracts guests from all over the world, drawn to the second city's style, thriving intellectual life, and liveliness.
Start off your visit on the 16th (Mon): contemplate the geological forces at Momotombo and then get impressive views of Cerro Negro Volcano. Get ready for a full day of sightseeing on the 17th (Tue): get impressive views of Telica Volcano, take in the architecture and atmosphere at Iglesia San Juan Bautista de Subtiava, and then pause for some serene contemplation at Catedral de la Asunción.

For photos, traveler tips, more things to do, and more tourist information, refer to the Leon online holiday planner .

Traveling by car from San Juan del Sur to Leon takes 3.5 hours. Alternatively, you can take a shuttle; or take a bus. Traveling from San Juan del Sur in December, expect nights in Leon to be about the same, around 26°C, while days are somewhat warmer, around 38°C. Wrap up your sightseeing by early afternoon on the 18th (Wed) to allow time for travel back home.

Things to do in Leon

Parks Nature Museums
Highlights from your plan
Cerro Negro Volcano ©
Cerro Negro Volcano
Momotombo ©
Momotombo
Catedral de la Asunción ©
Catedral de la Asunción

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