5 days in Southeast Missouri Itinerary

West Plains is a city in Howell County, Missouri, United States. Kick off your visit on the 9th (Wed): don't miss a visit to Ozark Heritage Welcome Center and then pick up a one of a kind souvenir at Downtown Antiques Mall.

Find out how to plan West Plains trip without stress by asking Inspirock to help create an itinerary.

Little Rock to West Plains is an approximately 3.5-hour car ride. Prepare for slightly colder weather when traveling from Little Rock in September: high temperatures in West Plains hover around 83°F and lows are around 59°F. Finish your sightseeing early on the 9th (Wed) so you can travel to Cape Girardeau.

Cape Girardeau is a city in Cape Girardeau and Scott counties in the U.S. On the 10th (Thu), take in panoramic vistas at Mississippi River Observation Deck, then view the masterpieces at New Madrid Historical Museum, then steep yourself in history at Hunter-Dawson State Historic Site, and finally get engrossed in the history at Higgerson School Historic Site. Here are some ideas for day two: pause for some serene contemplation at McKendree Chapel, then see the interesting displays at Crisp Museum, then take in the spiritual surroundings of Old St.Vincent's Church, and finally see the interesting displays at The Red House Interpretive Center.

To find where to stay, more things to do, and other tourist information, read Cape Girardeau day trip tool.

You can drive from West Plains to Cape Girardeau in 3.5 hours. In September, plan for daily highs up to 83°F, and evening lows to 58°F. Finish up your sightseeing early on the 11th (Fri) so you can go by car to Sainte Genevieve.

Ste. On the 12th (Sat), take in the spiritual surroundings of Sainte Genevieve Catholic Parish, contemplate the long history of Felix Valle House State Historic Site, take an in-depth tour of Bolduc House Museum, then take in the exciting artwork at ASL Pewter, and finally learn about winemaking at Watertower Winery.

To find where to stay, photos, more things to do, and tourist information, you can read our Sainte Genevieve online visit planner.

Traveling by car from Cape Girardeau to Sainte Genevieve takes 1.5 hours. In September, daytime highs in Sainte Genevieve are 81°F, while nighttime lows are 59°F. Wrap up your sightseeing on the 12th (Sat) early enough to travel to New Haven.

New Haven is a city in Franklin County, Missouri, United States. On the 13th (Sun), appreciate the extensive heritage of John Colter Memorial, do a tasting at Bommarito Estate Almond Tree Winery, then learn about winemaking at Robller Vineyard, then view the masterpieces at Astral Glass Studio and Gallery, and finally brush up on your knowledge of spirits at Pinckney Bend Distillery.

Plan my trip to New Haven with suggested itineraries provided by Inspirock.

Traveling by car from Sainte Genevieve to New Haven takes 2 hours. In September, plan for daily highs up to 81°F, and evening lows to 58°F. Wrap up your sightseeing on the 13th (Sun) early enough to travel back home.