49 days in Panama City & South America Itinerary

49 days in Panama City & South America Itinerary

Created using Inspirock itinerary planner

Make it your trip
+2
Ferry to San Cristobal, Fly to Baltra Island, Fly to Panama City
1
Panama City, Panama
— 2 nights
Fly
2
Bogota, Colombia
— 3 nights
Fly
3
Machu Picchu, Peru
— 2 nights
Train to Ollantaytambo, Bus to Cusco
4
Cusco, Peru
— 2 nights
Fly
5
Santiago, Chile
— 3 nights
Fly
6
Buenos Aires, Argentina
— 4 nights
Fly to Porto Alegre, Bus to Gramado
7
Gramado, Brazil
— 2 nights
Bus to Porto Alegre, Fly to Foz do Iguacu
8
Foz do Iguacu, Brazil
— 2 nights
+2
Fly to Rio De Janeiro Santos Dumont, Bus to Conceição de Jacareí, Ferry to Ilha Grande
9
Ilha Grande, Brazil
— 4 nights
Ferry to Conceição de Jacareí, Bus to Rio de Janeiro
10
Rio de Janeiro, Brazil
— 4 nights
Fly
11
Fernando de Noronha, Brazil
— 5 nights
Fly
12
Puerto Baquerizo Moreno, Ecuador
— 4 nights
Ferry
13
Puerto Villamil, Ecuador
— 2 nights
Ferry
14
Puerto Ayora, Ecuador
— 5 nights
Unknown

S M T W T F S
20
21
22
23
24
25
26
27
28
29
30
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
1
2
3
4
5
6
7
8
9
10
11
12
13
14

Panama City, Panama

— 2 nights

Dubai of Latin America

Arguably the most modern of Central American cities, Panama City boasts a shimmering skyline of glass skyscrapers.
Kick off your visit on the 22nd (Tue): appreciate the extensive heritage of Casco Viejo, then take an in-depth tour of Museo del Canal Interoceanico de Panama, and then get to know the fascinating history of Avenida Balboa. Keep things going the next day: don't miss a visit to Amador Causeway (Calzada de Amador), then don't miss a visit to Panama Canal, and then take in the exciting artwork at Galeria de arte Indigena.

To see maps, photos, and other tourist information, read Panama City trip itinerary site.

Puerto Ayora, Ecuador to Panama City is an approximately 12.5-hour combination of ferry and flight. In June, daily temperatures in Panama City can reach 36°C, while at night they dip to 29°C. Finish your sightseeing early on the 23rd (Wed) to allow enough time to fly to Bogota.

Things to do in Panama City

Historic Sites · Neighborhoods · Museums · Shopping

Bogota, Colombia

— 3 nights

Athens of South America

Colombia's heart and soul, Bogota has earned the nickname "Athens of South America" thanks to its abundance of universities, libraries, and lower-level schools.
Venture out of the city with trips to Ospina Park (in Chia) and Catedral de Sal de Zipaquira (in Zipaquira). The adventure continues: see the interesting displays at Gold Museum (Museo del Oro), savor the flavors at Food & Drink, take in nature's colorful creations at Piero Jardinero, and explore the world behind art at Museo Botero del Banco de la Republica.

To see photos, where to stay, reviews, and tourist information, read Bogota travel planner.

Getting from Panama City to Bogota by flight takes about 5 hours. In June, Bogota is colder than Panama City - with highs of 22°C and lows of 11°C. Cap off your sightseeing on the 26th (Sat) early enough to catch the flight to Machu Picchu.

Things to do in Bogota

Museums · Tours · Parks · Nature

Side Trips

Machu Picchu, Peru

— 2 nights
A symbol of the Incan civilization, the abandoned city of Machu Picchu represents a must-see on a Peru vacation.
On the 27th (Sun), steep yourself in history at Santuario Historico de Machu Picchu and then soothe aching muscles at Otto's Salon Spa & Boutique. On the 28th (Mon), you'll have a packed day of sightseeing: take in nature's colorful creations at Mandor, make a trip to Plaza Manco Capac, and then witness a stunning natural landmark at Hot Springs (Aguas Calientes).

To find ratings, reviews, maps, and tourist information, read Machu Picchu sightseeing planner.

You can fly from Bogota to Machu Picchu in 6.5 hours. Other options are to drive; or do a combination of bus and car. Finish your sightseeing early on the 28th (Mon) to allow enough time to travel to Cusco.

Things to do in Machu Picchu

Historic Sites · Parks · Nature · Spas

Cusco, Peru

— 2 nights

Imperial City

Capital of the Inca Empire for three centuries, World Heritage-listed Cusco is now a major tourist destination, drawing nearly 2 million annual tourists with its well-preserved colonial architecture and proximity to Machu Picchu.
On the 29th (Tue), get engrossed in the history at Museo de Arte Precolombino, contemplate the long history of Sacsayhuaman, and then take in the spiritual surroundings of Qorikancha. Keep things going the next day: admire the landmark architecture of Centro Historico De Cusco, steep yourself in history at Plaza de Armas, and then get engrossed in the history at Museo Inka.

Plan trip to Cusco with our itinerary maker to find out where to go and what to do.

Traveling by combination of train and bus from Machu Picchu to Cusco takes 4 hours. Alternatively, you can take a train; or drive. In June, daily temperatures in Cusco can reach 24°C, while at night they dip to 1°C. Wrap up your sightseeing on the 30th (Wed) to allow time to fly to Santiago.

Things to do in Cusco

Historic Sites · Museums

Santiago, Chile

— 3 nights

City of the Island Hills

Santiago tourism thrives largely thanks to the city's big selection of cultural and entertainment options, including museums, theaters, restaurants, bars, and giant malls.
Santiago is known for shopping, parks, and museums. Your trip includes some of its best attractions: walk around Cerro Santa Lucia, look for gifts at Patio Bellavista, get engrossed in the history at Museo Chileno de Arte Precolombino, and browse the eclectic array of goods at Central Market (Mercado Central).

For reviews, where to stay, maps, and more tourist information, use the Santiago trip website.

Traveling by flight from Cusco to Santiago takes 6.5 hours. Alternatively, you can drive; or take a bus. Due to the time zone difference, you'll lose 1 hour traveling from Cusco to Santiago. Finish up your sightseeing early on the 3rd (Sat) so you can catch the flight to Buenos Aires.

Things to do in Santiago

Museums · Shopping · Parks · Neighborhoods

Buenos Aires, Argentina

— 4 nights

Queen of La Plata

Cultural capital of South America, Buenos Aires remains one of the largest cities on the continent, serving as a point of departure for exploring the rest of the country.
Buenos Aires is known for historic sites, nightlife, and parks. Your trip includes some of its best attractions: take in nature's colorful creations at Parque 3 de Febrero, get a taste of the local shopping with Puerto Madero, make a trip to Cemiterio de Recoleta, and admire the masterpieces at Museo Nacional de Bellas Artes.

To see photos, where to stay, other places to visit, and more tourist information, read Buenos Aires trip itinerary planning app.

Fly from Santiago to Buenos Aires in 5.5 hours. Alternatively, you can drive; or take a bus. The time zone difference moving from Chile Standard Time to Argentina Standard Time is 1 hour. July in Buenos Aires sees daily highs of 17°C and lows of 10°C at night. Finish up your sightseeing early on the 7th (Wed) so you can travel to Gramado.

Things to do in Buenos Aires

Historic Sites · Museums · Neighborhoods · Shopping

Gramado, Brazil

— 2 nights

Hydrangea Garden

Surrounded by impressive mountain scenery in the state of Rio Grande do Sul, the small city of Gramado charms visitors with its alpine European-style architecture and blossoming flowers.
Kick off your visit on the 8th (Thu): look for gifts at Chocolate Dolcemonte - Gramado, pause for some serene contemplation at Paroquia Nossa Senhora de Lourdes, then admire the majestic nature at Parque Estadual do Caracol, and finally take in the architecture and atmosphere at Igreja Matriz Sao Pedro Apostolo. On the 9th (Fri), you'll have a packed day of sightseeing: don't miss a visit to Rua Coberta, explore the activities along Lago Negro, and then walk around Mini Mundo.

Before you visit Gramado, use our trip planner to discover what you can do and see there.

You can do a combination of flight and bus from Buenos Aires to Gramado in 7 hours. Other options are to drive; or take a bus. Wrap up your sightseeing on the 9th (Fri) to allow time to travel to Foz do Iguacu.

Things to do in Gramado

Parks · Nature · Historic Sites · Shopping

Side Trip

Foz do Iguacu, Brazil

— 2 nights

Land of the Waterfalls

A gateway to the world-renowned Iguacu Falls, which spectacularly divide Brazil and Argentina, the modern, high-rise city of Foz do Iguacu can't help but play second fiddle to the natural wonder in its vicinity.
Start off your visit on the 10th (Sat): see the interesting displays at Itaipu Ecomuseu, admire the engineering at Itaipu Dam, take in the spiritual surroundings of Buddhist Temple, then contemplate the long history of Marco Das Tres Fronteiras, and finally take an unforgettable tour with a helicopter tour. On the next day, get to know the resident critters at Parque das Aves Bird Park.

To see reviews, other places to visit, ratings, and tourist information, refer to the Foz do Iguacu day trip site.

You can do a combination of bus and flight from Gramado to Foz do Iguacu in 5.5 hours. Alternatively, you can drive; or do a combination of taxi, train, and bus. In July, daytime highs in Foz do Iguacu are 25°C, while nighttime lows are 13°C. Finish up your sightseeing early on the 11th (Sun) so you can travel to Ilha Grande.

Things to do in Foz do Iguacu

Parks · Historic Sites · Zoos & Aquariums · Museums

Ilha Grande, Brazil

— 4 nights
A tumultuous and unsavory history has kept Ilha Grande relatively undeveloped and free of the trappings of the modern world.
Ilha Grande is known for beaches, nature, and wildlife. Your trip includes some of its best attractions: take your sightseeing to a higher altitude at Pico do Papagaio, soothe aching muscles at Namaste Terapias Corporais, kick back and relax at Lopes Mendes Beach, and stroll through Aventureiro.

For reviews, maps, other places to visit, and tourist information, refer to the Ilha Grande trip itinerary tool.

You can do a combination of flight, bus, and ferry from Foz do Iguacu to Ilha Grande in 8.5 hours. Alternatively, you can do a combination of car and ferry; or do a combination of bus, car, and ferry. Traveling from Foz do Iguacu in July, expect Ilha Grande to be somewhat warmer, temps between 30°C and 19°C. Finish up your sightseeing early on the 15th (Thu) so you can travel to Rio de Janeiro.

Things to do in Ilha Grande

Parks · Outdoors · Beaches · Nature

Rio de Janeiro, Brazil

— 4 nights

Marvelous City

Bustling with samba music and all-night street parties, no city encapsulates the spirit of Brazil better than Rio de Janeiro.
Explore the numerous day-trip ideas around Rio de Janeiro: Petropolis (Sagrado Coracao de Jesus Church, Museu Casa de Santos Dumont, &more). Next up on the itinerary: pause for some photo ops at Corcovado - Christ the Redeemer, explore the historical opulence of Ilha Fiscal, enjoy the sand and surf at Praia de Ipanema, and take in nature's colorful creations at Jardim Botânico do Rio de Janeiro.

For maps, more things to do, ratings, and tourist information, read Rio de Janeiro online tour planner.

You can do a combination of ferry and bus from Ilha Grande to Rio de Janeiro in 5 hours. Another option is to do a combination of ferry, bus, and train. Expect a daytime high around 30°C in July, and nighttime lows around 22°C. Cap off your sightseeing on the 19th (Mon) early enough to catch the flight to Fernando de Noronha.

Things to do in Rio de Janeiro

Parks · Outdoors · Beaches · Museums

Side Trip

Fernando de Noronha, Brazil

— 5 nights

Emerald of the Atlantic

With 21 lush islands scattered among pristine waters in the Atlantic Ocean, a Fernando de Noronha holiday is well worth the effort it takes to get there.
Fernando de Noronha is known for beaches, museums, and wildlife. Your trip includes some of its best attractions: get outside with Baia dos Porcos, enjoy the sand and surf at Praia do Sueste, look and learn at Aulas de Energia – Espaco Usina Solar Fernando de Noronha, and stroll through Fernado de Noronha Island.

To find photos, where to stay, reviews, and more tourist information, refer to the Fernando de Noronha trip planning site.

Traveling by flight from Rio de Janeiro to Fernando de Noronha takes 7 hours. You'll lose 1 hour traveling from Rio de Janeiro to Fernando de Noronha due to the time zone difference. Expect a bit warmer evenings in Fernando de Noronha when traveling from Rio de Janeiro in July, with lows around 28°C. Wrap up your sightseeing on the 24th (Sat) early enough to travel to Puerto Baquerizo Moreno.

Things to do in Fernando de Noronha

Outdoors · Parks · Beaches · Museums

Puerto Baquerizo Moreno, Ecuador

— 4 nights
The capital of the Galapagos Islands, Puerto Baquerizo Moreno is located on easternmost island of the archipelago, San Cristobal.
Spend the 26th (Mon) exploring nature at Cerro Tijeretas. Next up on the itinerary: learn more about the world around you at Interpretation Center, enjoy the sand and surf at Playa de Oro, don't miss a visit to Dona Pilo, and stroll through Playa Mann.

For maps, reviews, where to stay, and tourist information, refer to the Puerto Baquerizo Moreno journey builder tool.

The Route module can help you plan travel from Fernando de Noronha to Puerto Baquerizo Moreno. The time zone difference moving from Fernando de Noronha Standard Time (FNT) to Ecuador Time (ECT) is minus 3 hours. In July, daytime highs in Puerto Baquerizo Moreno are 31°C, while nighttime lows are 25°C. Cap off your sightseeing on the 29th (Thu) early enough to catch the ferry to Puerto Villamil.

Things to do in Puerto Baquerizo Moreno

Parks · Outdoors · Wildlife · Beaches

Side Trip

Puerto Villamil, Ecuador

— 2 nights
Located in the southeast of Isla Isabela, Puerto Villamil is home to the majority of the island's 2,200 inhabitants.
Start off your visit on the 30th (Fri): don't miss a visit to The Wall of Tears, then head outdoors with Los Tuneles, then contemplate the waterfront views at Laguna de los Diablos, and finally don't miss a visit to Malecon Cuna del Sol. Get ready for a full day of sightseeing on the 31st (Sat): tour the pleasant surroundings at Posada de flamengos and then contemplate the geological forces at Sierra Negra.

To find ratings, photos, where to stay, and other tourist information, refer to the Puerto Villamil trip planner.

You can ride a ferry from Puerto Baquerizo Moreno to Puerto Villamil in 6 hours. The time zone difference moving from Ecuador Time to Galapagos Time is minus 1 hour. Finish your sightseeing early on the 31st (Sat) to allow enough time to ride a ferry to Puerto Ayora.

Things to do in Puerto Villamil

Parks · Nature · Wildlife · Tours

Side Trip

Puerto Ayora, Ecuador

— 5 nights
The largest settlement in the Galapagos, Puerto Ayora offers visitors to the islands an array of facilities and things to do.
Puerto Ayora is known for parks, nature, and wildlife. Your trip includes some of its best attractions: stroll through Charles Darwin Research Station, shop like a local with The Angelique Art Gallery, view the masterpieces at Galeria Aymara, and take in the dramatic natural features at Las Grietas.

For ratings, more things to do, where to stay, and other tourist information, use the Puerto Ayora online attractions planner.

You can ride a ferry from Puerto Villamil to Puerto Ayora in 3.5 hours. The time zone difference when traveling from Puerto Villamil to Puerto Ayora is 1 hour. In July, daily temperatures in Puerto Ayora can reach 31°C, while at night they dip to 25°C. Cap off your sightseeing on the 5th (Thu) early enough to travel back home.

Things to do in Puerto Ayora

Parks · Wildlife · Outdoors · Nature

Side Trip