46 days in South America Itinerary

46 days in South America Itinerary

Created using Inspirock South America sightseeing planner

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Route & dates

46 days in South America Itinerary

Start: Toronto, Canada
Fly:  9​h 45​min
1
Quito, Ecuador
— 3 nights
+3
Fly + shuttle + ferry + bus:  8​h
2
Puerto Ayora, Ecuador
— 3 nights
+3
bus + ferry + shuttle + Fly:  5​h 45​min
3
Guayaquil, Ecuador
— 1 night
Fly:  2​h 30​min
4
Lima, Peru
— 3 nights
Fly + Drive:  12​h
5
Machu Picchu, Peru
— 1 day
+2
train + foot + bus:  3​h 15​min
6
Cusco, Peru
— 3 nights
Fly + bus:  1​h 45​min
7
La Paz, Bolivia
— 3 nights
Fly:  5​h
8
Asuncion, Paraguay
— 1 night
Fly:  4​h 15​min
9
Rio de Janeiro, Brazil
— 4 nights
Fly + bus:  1​h 30​min
10
Sao Paulo, Brazil
— 3 nights
Fly + taxi:  4​h 15​min
11
Gramado, Brazil
— 3 nights
bus + Fly:  6​h 15​min
12
Montevideo, Uruguay
— 3 nights
ferry:  2​h 15​min
13
Buenos Aires, Argentina
— 3 nights
Fly:  5​h 15​min
14
San Carlos de Bariloche, Argentina
— 2 nights
Fly:  9​h 45​min
15
Santiago, Chile
— 3 nights
Fly + shuttle:  5​h
16
San Pedro de Atacama, Chile
— 4 nights
shuttle + Fly:  17​h 30​min
End: Toronto, Canada

3
nights
Quito, Ecuador

Quito ©
High in the Andean foothills, Quito remains one of the world's most photogenic capital cities, featuring two dramatic mountain ranges as its backdrop.
Venture out of the city with trips to Termas de Papallacta (in Papallacta) and Pichincha (in Puerto Quito). There's still lots to do: contemplate in the serene atmosphere at Fundacion Iglesia de la Compania, get in on the family fun at Nayon Xtreme Valley, take an in-depth tour of Museo Templo del Sol Pintor Ortega Maila, and examine the collection at La Capilla Del Hombre.

To find reviews, ratings, traveler tips, and tourist information, you can read our Quito tour itinerary builder tool .

Toronto, Canada to Quito is an approximately 10-hour flight. You can also do a combination of bus and flight. Prepare for somewhat warmer weather when traveling from Toronto in October: high temperatures in Quito hover around 26°C and lows are around 17°C. Cap off your sightseeing on the 4th (Fri) early enough to travel to Puerto Ayora.

Things to do in Quito

Nature Parks Museums

Side Trips

Termas de Papallacta, Pichincha
Highlights from your plan
Fundacion Iglesia de la Compania ©
Mitad Del Mundo ©
Mitad Del Mundo

3
nights
Puerto Ayora, Ecuador

Puerto Ayora ©
The largest settlement in the Galapagos, Puerto Ayora offers visitors to the islands an array of facilities and things to do.
Change things up with a short trip to North Seymour Island in Baltra (about 1h 20 min away). Next up on the itinerary: look for all kinds of wild species at Charles Darwin Research Station, make a trip to Dragon Hill (Cerro Dragon), kick back and relax at Playa las Bachas, and get a taste of life in the country at Rancho Primicias.

To find more things to do, maps, reviews, and more tourist information, read Puerto Ayora trip itinerary planning app .

Getting from Quito to Puerto Ayora by combination of flight and ferry takes about 8 hours. Traveling from Quito in October, things will get a bit warmer in Puerto Ayora: highs are around 30°C and lows about 24°C. Finish up your sightseeing early on the 8th (Tue) so you can travel to Guayaquil.

Things to do in Puerto Ayora

Parks Wildlife Beaches

Side Trips

Santa Cruz, El Trapiche Ecologico Galapagos, North Seymour Island
Highlights from your plan
Charles Darwin Research Station ©
Charles Darwin Research Station
El Chato - Giant Tortoise Reserve ©
El Chato - Giant Tortoise Reserve
Galeria Aymara ©
Galeria Aymara

1
night
Guayaquil, Ecuador

Guayaquil ©
Hills dotted with colorful houses and waterfront promenades typify Guayaquil, Ecuador's largest city and commercial center.
Start off your visit on the 9th (Wed): wander the streets of Cerro Santa Ana, get a taste of life in the country at Hacienda La Danesa Lodge, and then wander the streets of Las Penas.

To find where to stay, photos, and other tourist information, use the Guayaquil online holiday maker .

You can do a combination of ferry and flight from Puerto Ayora to Guayaquil in 6 hours. Traveling from Puerto Ayora in October, you will find days in Guayaquil are a bit warmer (35°C), and nights are about the same (25°C). Finish your sightseeing early on the 9th (Wed) so you can travel to Lima.

Things to do in Guayaquil

Neighborhoods
Highlights from your plan
Las Penas ©
Las Penas
Cerro Santa Ana ©
Cerro Santa Ana

3
nights
Lima, Peru

Lima ©
Founded in 1535 by Spanish explorer Francisco Pizarro, Lima represents an interesting blend of modern attractions and preserved colonial architecture, much of it clustered in the World Heritage-listed city center.
Lima is known for parks, historic sites, museums, shopping, and nightlife. Your plan includes some of its best attractions: get engrossed in the history at Museo Larco, delve into the distant past at Huaca Pucllana, let your taste buds guide you at a local gastronomic tour, and shop like a local with Shopping Center Larcomar (Centro Comercial Larcomar).

For ratings, other places to visit, more things to do, and more tourist information, go to the Lima trip maker app .

Traveling by flight from Guayaquil to Lima takes 2.5 hours. Alternatively, you can drive; or take a bus. Expect a bit cooler temperatures when traveling from Guayaquil in October; daily highs in Lima reach 24°C and lows reach 19°C. Finish up your sightseeing early on the 12th (Sat) so you can travel to Machu Picchu.

Things to do in Lima

Historic Sites Museums Neighborhoods
Highlights from your plan
Huaca Pucllana ©
Huaca Pucllana
Museo Larco ©
Museo Larco
Plaza de Armas (Plaza Mayor) ©
Plaza de Armas (Plaza Mayor)

1
day
Machu Picchu, Peru

Machu Picchu ©
A symbol of the Incan civilization, the abandoned city of Machu Picchu represents a must-see on a Peru vacation.
On the 13th (Sun), delve into the distant past at Santuario Historico de Machu Picchu.

For where to stay, photos, other places to visit, and tourist information, go to the Machu Picchu online route planner .

Traveling by combination of flight and car from Lima to Machu Picchu takes 12 hours. Alternatively, you can drive; or do a combination of bus and taxi. Cap off your sightseeing on the 13th (Sun) early enough to travel to Cusco.

Things to do in Machu Picchu

Historic Sites
Highlights from your plan
Santuario Historico de Machu Picchu ©

3
nights
Cusco, Peru

Cusco ©
Capital of the Inca Empire for three centuries, World Heritage-listed Cusco is now a major tourist destination, drawing nearly 2 million annual tourists with its well-preserved colonial architecture and proximity to Machu Picchu.
Change things up with a short trip to Salinas de Maras in Maras (about 1h 15 min away). The adventure continues: steep yourself in history at Sacsayhuaman, explore the world behind art at Museo de Arte Precolombino, take an in-depth tour of Museo Inka, and delve into the distant past at Tambomachay.

To see traveler tips, reviews, maps, and more tourist information, go to the Cusco online trip builder .

Do a combination of train and bus from Machu Picchu to Cusco in 3.5 hours. Alternatively, you can take a train; or drive. In October in Cusco, expect temperatures between 24°C during the day and 7°C at night. Finish your sightseeing early on the 16th (Wed) so you can travel to La Paz.

Things to do in Cusco

Historic Sites Museums Parks

Side Trips

Sacred Valley of the Incas, Salinas de Maras
Highlights from your plan
exploor ©
exploor
Sacsayhuaman ©
Sacsayhuaman
Plaza de Armas ©
Plaza de Armas

3
nights
La Paz, Bolivia

La Paz ©
Take a moment to catch your breath as you commence your holiday in La Paz.
La Paz is known for historic sites, nature, scenic drive, museums, and fun & games. Your plan includes some of its best attractions: delve into the distant past at Tiwanaku, explore and take pictures at WMDR Yungas Road, take in the dramatic natural features at Valley of the Moon, and push the limits with an extreme tour.

For other places to visit, where to stay, maps, and more tourist information, refer to the La Paz planner .

You can do a combination of flight and bus from Cusco to La Paz in 2 hours. Alternatively, you can drive; or take a bus. The time zone changes from Peru Time (PET) to Bolivia Time (BOT), which is usually a 1 hour difference. Prepare for a bit cooler weather when traveling from Cusco in October: high temperatures in La Paz hover around 19°C and lows are around 1°C. Wrap up your sightseeing on the 19th (Sat) to allow time to travel to Asuncion.

Things to do in La Paz

Outdoors Scenic Drive Nature
Highlights from your plan
Urban Rush Bolivia ©
Urban Rush Bolivia
Tiwanaku ©
Tiwanaku
WMDR Yungas Road ©
WMDR Yungas Road

1
night
Asuncion, Paraguay

Asuncion ©
Paraguay's capital and economic center, Asuncion ranks among the youngest cities on the continent, with more than half of its residents under 30 years of age.
Kick off your visit on the 20th (Sun): appreciate the history behind The National Pantheon of Heroes and Oratory of the Virgin Our Lady Saint Mary of the Asuncion, ponder the world of politics at Palacio de López, don't miss a visit to Costanera de Asuncion, then test your team's savvy at popular escape rooms, and finally get outside with Parque Nu Guasu.

To find other places to visit, where to stay, and other tourist information, you can read our Asuncion road trip planner .

Traveling by flight from La Paz to Asuncion takes 5 hours. Alternatively, you can take a bus; or drive. Prepare for much hotter weather when traveling from La Paz in October: high temperatures in Asuncion hover around 35°C and lows are around 22°C. Finish your sightseeing early on the 20th (Sun) so you can travel to Rio de Janeiro.

Things to do in Asuncion

Outdoors Fun & Games
Highlights from your plan

4
nights
Rio de Janeiro, Brazil

Rio de Janeiro ©
Bustling with samba music and all-night street parties, no city encapsulates the spirit of Brazil better than Rio de Janeiro.
Rio de Janeiro is known for beaches, nature, parks, museums, and nightlife. Your plan includes some of its best attractions: take some stellar pictures from Pao de Acucar, kick back and relax at Barra da Tijuca Beach, tour the pleasant surroundings at Praia de Grumari, and explore and take pictures at Leblon Beach.

For ratings, more things to do, photos, and other tourist information, you can read our Rio de Janeiro visit planner .

Fly from Asuncion to Rio de Janeiro in 4.5 hours. Alternatively, you can drive; or take a bus. The time zone difference when traveling from Asuncion to Rio de Janeiro is 1 hour. Expect a daytime high around 32°C in October, and nighttime lows around 24°C. Finish your sightseeing early on the 24th (Thu) to allow enough time to travel to Sao Paulo.

Things to do in Rio de Janeiro

Parks Beaches Outdoors
Highlights from your plan
Pao de Acucar ©
Pao de Acucar
Corcovado Christ the Redeemer ©
Corcovado Christ the Redeemer
Copacabana Beach ©
Copacabana Beach

3
nights
Sao Paulo, Brazil

Sao Paulo ©
Don't let the city's nickname--"Land of Drizzle"--dampen your spirits during a trip to Sao Paulo.
Sao Paulo is known for museums, shopping, parks, nightlife, and historic sites. Your plan includes some of its best attractions: stroll around Parque Ibirapuera, explore the world behind art at Museu de Arte de Sao Paulo Assis Chateaubriand - MASP, see the interesting displays at Museu da Lingua Portuguesa, and test your problem-solving skills at popular escape rooms.

To see more things to do, other places to visit, and more tourist information, read our Sao Paulo online driving holiday planner .

Traveling by combination of flight and bus from Rio de Janeiro to Sao Paulo takes 1.5 hours. Alternatively, you can fly; or drive. Traveling from Rio de Janeiro in October, expect a bit cooler with lows of 20°C in Sao Paulo. Finish up your sightseeing early on the 27th (Sun) so you can travel to Gramado.

Things to do in Sao Paulo

Museums Shopping Fun & Games
Highlights from your plan
Parque Ibirapuera ©
Parque Ibirapuera
Paulista Avenue ©
Paulista Avenue
Pinacoteca do Estado de Sao Paulo ©
Pinacoteca do Estado de Sao Paulo

3
nights
Gramado, Brazil

Gramado ©
Surrounded by impressive mountain scenery in the state of Rio Grande do Sul, the small city of Gramado charms visitors with its alpine European-style architecture and blossoming flowers.
You'll find plenty of places to visit near Gramado: Miragem Livraria (in Sao Francisco de Paula) and Canyoning & Rappelling Tours (in Tres Coroas). Next up on the itinerary: stroll around Mini Mundo, make a trip to Rua Coberta, pause for some serene contemplation at Igreja Matriz Sao Pedro Apostolo, and get in on the family fun at Snowland.

For maps, more things to do, traveler tips, and more tourist information, use the Gramado vacation builder .

Getting from Sao Paulo to Gramado by combination of flight and taxi takes about 4.5 hours. Other options: do a combination of bus, flight, and taxi; or drive. Wrap up your sightseeing on the 30th (Wed) early enough to travel to Montevideo.

Things to do in Gramado

Parks Theme Parks Outdoors

Side Trips

Canela, Miragem Livraria, Canyoning & Rappelling Tours
Highlights from your plan
Mini Mundo ©
Mini Mundo
Snowland ©
Snowland
Igreja Matriz Sao Pedro Apostolo ©
Igreja Matriz Sao Pedro Apostolo

3
nights
Montevideo, Uruguay

Montevideo ©
With a rich cultural scene and plenty of developed beaches, Montevideo vacations appeal to a growing number of visitors from around the world.
Step out of Montevideo with an excursion to Pizzorno Family Estates in Canelones--about 44 minutes away. And it doesn't end there: don't miss a visit to Plaza Independencia, explore the world behind art at Museo Municipal de Bellas Artes Juan Manuel Blanes, take a stroll through Ciudad Vieja, and admire the striking features of Palacio Salvo.

To find where to stay, maps, and more tourist information, go to the Montevideo road trip planning app .

Do a combination of bus and flight from Gramado to Montevideo in 6.5 hours. Alternatively, you can drive; or take a bus. Expect a daytime high around 23°C in October, and nighttime lows around 13°C. Finish up your sightseeing early on the 2nd (Sat) so you can catch the ferry to Buenos Aires.

Things to do in Montevideo

Shopping Neighborhoods Museums

Side Trip

Pizzorno Family Estates
Highlights from your plan
Mercado del Puerto ©
Mercado del Puerto
Plaza Independencia ©
Plaza Independencia
Rambla de Montevideo ©
Rambla de Montevideo

3
nights
Buenos Aires, Argentina

Buenos Aires ©
Cultural capital of South America, Buenos Aires remains one of the largest cities on the continent, serving as a point of departure for exploring the rest of the country.
Buenos Aires is known for nightlife, museums, parks, historic sites, and shopping. Your plan includes some of its best attractions: make a trip to Cemiterio de Recoleta, admire the landmark architecture of El Ateneo Grand Splendid, get a taste of the local shopping with Puerto Madero, and take in nature's colorful creations at Parque 3 de Febrero.

To find more things to do, photos, ratings, and more tourist information, use the Buenos Aires online travel planner .

You can ride a ferry from Montevideo to Buenos Aires in 2.5 hours. Alternatively, you can fly; or take a bus. Traveling from Montevideo in November, plan for somewhat warmer nights in Buenos Aires, with lows around 19°C. Finish your sightseeing early on the 5th (Tue) so you can travel to San Carlos de Bariloche.

Things to do in Buenos Aires

Neighborhoods Shopping Museums
Highlights from your plan
Puerto Madero ©
Puerto Madero
Cemiterio de Recoleta ©
Cemiterio de Recoleta
Parque 3 de Febrero ©
Parque 3 de Febrero

2
nights
San Carlos de Bariloche, Argentina

Nestled against the foothills of the Andes, scenic San Carlos de Bariloche hugs the southern shore of Nahuel Huapi Lake and ranks among Argentina's top destinations for active outdoor vacations.
Start off your visit on the 6th (Wed): add some adventure to your tour with a kayaking and canoeing tour and then stroll through Catedral Alta Patagonis. Get ready for a full day of sightseeing on the 7th (Thu): tour the pleasant surroundings at Circuito Chico, then take in panoramic vistas at Parque Nacional Nahuel Huapi, and then take some stellar pictures from Cerro Otto.

For where to stay, photos, traveler tips, and tourist information, refer to the San Carlos de Bariloche trip planner.

Traveling by flight from Buenos Aires to San Carlos de Bariloche takes 5.5 hours. Alternatively, you can drive; or take a bus. When traveling from Buenos Aires in November, plan for slightly colder days in San Carlos de Bariloche, with highs around 21°C, while nights are much colder with lows around 3°C. Cap off your sightseeing on the 7th (Thu) early enough to travel to Santiago.

Things to do in San Carlos de Bariloche

Parks Outdoors Winter Sports
Highlights from your plan
Kayaking & Canoeing
Catedral Alta Patagonis
Catedral Alta Patagonis
Parque Nacional Nahuel Huapi ©
Parque Nacional Nahuel Huapi

3
nights
Santiago, Chile

Santiago ©
Santiago tourism thrives largely thanks to the city's big selection of cultural and entertainment options, including museums, theaters, restaurants, bars, and giant malls.
Explore Santiago's surroundings by going to Valle Nevado - Ski Resort Chile (in Valle Nevado), Concha y Toro (in Pirque) and La Sebastiana (in Valparaiso). There's much more to do: take in the awesome beauty at San Cristóbal Hill, explore the world behind art at Museo Chileno de Arte Precolombino, take in panoramic vistas at Sky Costanera, and don't miss a visit to Plaza de Armas.

For photos, maps, where to stay, and more tourist information, go to the Santiago holiday maker .

Getting from San Carlos de Bariloche to Santiago by flight takes about 10 hours. Other options: do a combination of bus and flight; or drive. Traveling from San Carlos de Bariloche to Santiago, you'll gain 1 hour due to the time zone difference. Finish your sightseeing early on the 11th (Mon) so you can travel to San Pedro de Atacama.

Things to do in Santiago

Parks Museums Outdoors

Side Trips

Valle Nevado - Ski Resort Chile, Concha y Toro, La Sebastiana
Highlights from your plan
San Cristóbal Hill ©
San Cristóbal Hill
Santa Lucia Hill ©
Santa Lucia Hill
Patio Bellavista ©
Patio Bellavista

4
nights
San Pedro de Atacama, Chile

San Pedro de Atacama ©
Major archeological sites and a renowned museum remain the big draws in San Pedro de Atacama tourism, appealing to visitors interested in learning more about South America's pre-Columbian cultures.
San Pedro de Atacama is known for nature, wildlife, historic sites, nightlife, and childrens museums. Your plan includes some of its best attractions: take in the dramatic natural features at Valle De La Luna, don't miss a visit to Aldea de Tulor, see the interesting displays at Father Le Paige Museum, and take in the natural beauty of Geyser del Tatio.

To find photos, more things to do, traveler tips, and tourist information, read our San Pedro de Atacama trip tool .

You can do a combination of flight and shuttle from Santiago to San Pedro de Atacama in 5 hours. Alternatively, you can drive; or take a bus. In November in San Pedro de Atacama, expect temperatures between 28°C during the day and 3°C at night. Finish up your sightseeing early on the 15th (Fri) so you can travel back home.

Things to do in San Pedro de Atacama

Parks Nature Wildlife

Side Trip

Atacama Desert
Highlights from your plan
Atacama Desert ©
Atacama Desert
Valle De La Luna ©
Valle De La Luna
Geyser del Tatio ©
Geyser del Tatio

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