45 days in South America Itinerary

45 days in South America Itinerary

Created using Inspirock South America attractions planner

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Make it your trip
Fly
1
Buenos Aires, Argentina
— 2 nights
Bus
2
Cordoba, Argentina
— 2 nights
Drive
3
San Fernando del Valle de Catamarca, Argentina
— 2 nights
Drive
4
Cafayate, Argentina
— 2 nights
Bus
5
Salta, Argentina
— 3 nights
Drive
6
Tupiza, Bolivia
— 2 nights
Drive
7
Uyuni, Bolivia
— 2 nights
Fly
8
Sucre, Bolivia
— 3 nights
Fly
9
La Paz, Bolivia
— 2 nights
Drive
10
Copacabana, Bolivia
— 1 night
Drive
11
Puno, Peru
— 2 nights
Fly
12
Cusco, Peru
— 3 nights
Bus to Ollantaytambo, Train to Machu Picchu
13
Machu Picchu, Peru
— 1 night
Drive
14
Nazca, Peru
— 2 nights
Drive
15
Huacachina, Peru
— 1 night
Drive
16
Lima, Peru
— 2 nights
Fly
17
Huaraz, Peru
— 2 nights
Drive
18
Huanchaco, Peru
— 1 night
Fly to Talara, Bus to Mancora
19
Mancora, Peru
— 2 nights
Drive
20
Guayaquil, Ecuador
— 3 nights
Fly

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Buenos Aires, Argentina

— 2 nights

Queen of La Plata

Cultural capital of South America, Buenos Aires remains one of the largest cities on the continent, serving as a point of departure for exploring the rest of the country.
Get ready for a full day of sightseeing on the 2nd (Wed): wander the streets of Puerto Madero and then appreciate the extensive heritage of La Boca.

For reviews, traveler tips, more things to do, and other tourist information, read our Buenos Aires trip planner.

Queenstown, New Zealand to Buenos Aires is an approximately 20-hour flight. You can also fly. The time zone difference when traveling from Queenstown to Buenos Aires is minus 15 hours. Expect a daytime high around 18°C in June, and nighttime lows around 11°C. Finish your sightseeing early on the 3rd (Thu) to allow enough time to travel to Cordoba.

Things to do in Buenos Aires

Historic Sites · Neighborhoods · Museums · Shopping

Cordoba, Argentina

— 2 nights

The Learned One

History lives on in the streets of Cordoba, Argentina's second-largest city.
Kick off your visit on the 5th (Sat): take in the awesome beauty at Los Gigantes and then stroll through Balneario Playas de Oro.

For photos, ratings, more things to do, and more tourist information, read our Cordoba vacation planner.

Traveling by bus from Buenos Aires to Cordoba takes 9 hours. Alternatively, you can fly; or drive; or take a bus. When traveling from Buenos Aires in June, plan for a bit cooler days and about the same nights in Cordoba: temperatures range from 13°C by day to 11°C at night. Wrap up your sightseeing by early afternoon on the 6th (Sun) to allow time for travel to San Fernando del Valle de Catamarca.

Things to do in Cordoba

Parks · Outdoors · Beaches · Nature

Side Trip

San Fernando del Valle de Catamarca, Argentina

— 2 nights
Surrounded by impressive mountains, San Fernando del Valle de Catamarca sits in a scenic valley, on the banks of the Del Valle river.
Kick off your visit on the 7th (Mon): identify plant and animal life at Oasi di Antofalla, then explore the ancient world of Pueblo Perdido, and then make a trip to Iglesia y Convento de San Francisco. Keep things going the next day: head outdoors with Cuesta Del Portezuelo, then pause for some serene contemplation at Catedral Basilica de Nuestra Senora del Valle, and then make a trip to Plaza 25 de Mayo.

To see ratings, where to stay, and tourist information, read our San Fernando del Valle de Catamarca road trip tool.

You can drive from Cordoba to San Fernando del Valle de Catamarca in 5.5 hours. Alternatively, you can fly. Traveling from Cordoba in June, expect nights in San Fernando del Valle de Catamarca to be slightly colder, around 6°C, while days are a bit warmer, around 23°C. Finish your sightseeing early on the 8th (Tue) to allow enough time to travel to Cafayate.

Things to do in San Fernando del Valle de Catamarca

Outdoors · Wildlife · Historic Sites · Parks

Cafayate, Argentina

— 2 nights

Tuscany of Argentina

Nestled in one of the country's major wine regions, Cafayate and the surrounding area remain a top vacation destination throughout the year.
Kick off your visit on the 9th (Wed): learn about winemaking at Bodega Domingo Molina, tee off at La Estancia De Cafayate, and then take in the architecture and atmosphere at Catedral Nuestra Senora del Rosario. Keep things going the next day: learn about winemaking at Bodega Domingo Hermanos, look for gifts at Almas Viajeros Taller Artesanias, then see the interesting displays at Museo de la Vid y el Vino de Cafayate, Salta, Argentina, and finally delve into the distant past at Quilmes Ruins (Ruinas de Quilmes).

Inspirock's itinerary builder makes planning a Cafayate trip simple and quick.

Getting from San Fernando del Valle de Catamarca to Cafayate by car takes about 6 hours. Finish up your sightseeing early on the 10th (Thu) so you can go by car to Salta.

Things to do in Cafayate

Wineries · Golf · Outdoors · Historic Sites

Side Trip

Salta, Argentina

— 3 nights

Salta the Beautiful

Salta boasts a vibrant social life and array of informative museums appealing to visitors looking for a memorable cultural experience.
Kick off your visit on the 11th (Fri): contemplate the long history of Convento San Bernardo, then take a pleasant ride with a tour on horseback, and then take in the spiritual surroundings of Basilica Menor San Francisco. Get ready for a full day of sightseeing on the 12th (Sat): take a peaceful walk through Quebrada de San Lorenzo and then look for all kinds of wild species at Reserva del Huaico.

To find where to stay, photos, other places to visit, and tourist information, you can read our Salta road trip website.

You can take a bus from Cafayate to Salta in 11.5 hours. Alternatively, you can drive; or take a bus. June in Salta sees daily highs of 22°C and lows of 5°C at night. Finish your sightseeing early on the 13th (Sun) to allow enough time to travel to Tupiza.

Things to do in Salta

Parks · Outdoors · Nature · Tours

Side Trips

Tupiza, Bolivia

— 2 nights
The southwestern mining town of Tupiza, near the Argentine border, reminisces of the wild west, and is supposedly the place where Butch Cassidy and the Sundance Kid faced their demise after a long string of bank robberies.
Plan trip to Tupiza with our itinerary maker to find out where to go and what to do.

Traveling by car from Salta to Tupiza takes 7.5 hours. Alternatively, you can do a combination of flight and car. The time zone difference moving from Argentina Standard Time to Bolivia Time is minus 1 hour. On the 15th (Tue), you'll travel to Uyuni.

Things to do in Tupiza

Outdoors · Tours · Wildlife · Parks

Uyuni, Bolivia

— 2 nights
Emptiness surrounds the desert outpost of Uyuni, the gateway to the world's largest salt flats.
On the 16th (Wed), take in the architecture and atmosphere at Iglesia San Cristobal Lipez and then identify plant and animal life at Wildlife Areas. Here are some ideas for day two: head off the coast to Isla Incahuasi and then examine the collection at Necropolis & Museum Kawsay Wasy.

Use Inspirock's suggestions to plan your Uyuni trip and find the best activities and attractions for your vacation.

Drive from Tupiza to Uyuni in 4 hours. Alternatively, you can take a bus; or take a train. In June, daily temperatures in Uyuni can reach 8°C, while at night they dip to 7°C. Wrap up your sightseeing on the 17th (Thu) to allow time to travel to Sucre.

Things to do in Uyuni

Wildlife · Outdoors · Tours · Museums

Sucre, Bolivia

— 3 nights

City of the Four Names

The constitutional capital of Bolivia, Sucre has a well-preserved historic center, with many buildings dating back to the city's founding in the 16th century.
On the 18th (Fri), take in the dramatic scenery at The 7 Cascadas, then pause for some serene contemplation at Basilica de San Francisco, then examine the collection at Centro Turistico Comunitario, and finally pause for some serene contemplation at Sucre Cathedral. Get ready for a full day of sightseeing on the 19th (Sat): step into the grandiose world of La Glorieta Castle, pause for some serene contemplation at Iglesia Nuestra Senora de La Merced, make a trip to Universidad de San Francisco Xavier de Chuquisaca, then head outdoors with La Maja, and finally take in the spiritual surroundings of Santa Clara Convent.

For where to stay, reviews, other places to visit, and other tourist information, read our Sucre online driving holiday planner.

You can fly from Uyuni to Sucre in 5.5 hours. Other options are to drive; or take a bus. Expect warmer weather when traveling from Uyuni in June: highs in Sucre hover around 24°C, while lows dip to 5°C. Wrap up your sightseeing by early afternoon on the 20th (Sun) to allow time for travel to La Paz.

Things to do in Sucre

Historic Sites · Nature · Parks · Museums

La Paz, Bolivia

— 2 nights

City that Touches the Sky

Take a moment to catch your breath as you commence your holiday in La Paz.
Kick off your visit on the 20th (Sun): don't miss a visit to Calle Sagarnaga and then stroll around Plaza del Monticulo. Get ready for a full day of sightseeing on the next day: hike along Takesi Trail, then admire the striking features of Iglesia de San Francisco, then admire the masterpieces at National Museum of Art - Museo Nacional de Arte, and finally pause for some serene contemplation at Catedral Basilica Menor de Nuestra Senora de la Paz.

You can plan La Paz trip in no time by asking Inspirock to help create your itinerary.

Traveling by flight from Sucre to La Paz takes 3 hours. Alternatively, you can drive; or take a bus. In June, La Paz is a bit cooler than Sucre - with highs of 17°C and lows of -4°C. Cap off your sightseeing on the 22nd (Tue) early enough to go by car to Copacabana.

Things to do in La Paz

Parks · Shopping · Neighborhoods · Outdoors

Side Trip

Copacabana, Bolivia

— 1 night
The town of Copacabana represents the largest Bolivian settlement on the shore of Lake Titicaca, the largest lake in the continent.
For where to stay, maps, and other tourist information, go to the Copacabana vacation planner.

You can drive from La Paz to Copacabana in 3.5 hours. Alternatively, you can do a combination of bus and ferry. On the 23rd (Wed), you're off to Puno.

Things to do in Copacabana

Nature · Parks · Historic Sites · Outdoors

Puno, Peru

— 2 nights

City of the Lake

Hugging the western tip of Lake Titicaca, Puno serves as a melting pot of indigenous and imported cultures, and makes a great base for explorations around the region.
Start off your visit on the 23rd (Wed): contemplate the long history of Catedral de Chucuito, then contemplate the long history of La Casa del Corregidor, and then wander the streets of Luquina Chico. Get ready for a full day of sightseeing on the 24th (Thu): contemplate the waterfront views at Laguna Lagunillas, don't miss a visit to Portal de Aramu Muru, and then stroll the grounds of Sillustani.

To see reviews, more things to do, maps, and tourist information, use the Puno trip planner.

Getting from Copacabana to Puno by car takes about 2.5 hours. Other options: take a bus. The time zone changes from Bolivia Time (BOT) to Peru Standard Time (PET), which is usually a -1 hour difference. In June in Puno, expect temperatures between 21°C during the day and -5°C at night. Cap off your sightseeing on the 25th (Fri) early enough to travel to Cusco.

Things to do in Puno

Historic Sites · Neighborhoods · Nature · Parks

Side Trip

Cusco, Peru

— 3 nights

Imperial City

Capital of the Inca Empire for three centuries, World Heritage-listed Cusco is now a major tourist destination, drawing nearly 2 million annual tourists with its well-preserved colonial architecture and proximity to Machu Picchu.
Your inner history buff will appreciate Sacsayhuaman and Tipon. Step off the beaten path and head to Sacred Valley of the Incas and Santuario Animal de Cochahuasi. Next up on the itinerary: let the river carry you with a rafting and tubing tour and soothe aching muscles at some of the top local wellness centers.

For reviews, where to stay, maps, and other tourist information, go to the Cusco trip planner.

Traveling by flight from Puno to Cusco takes 4.5 hours. Alternatively, you can drive; or take a bus. Traveling from Puno in June, you can expect nighttime temperatures to be a bit warmer in Cusco, with lows of 1°C. Finish up your sightseeing early on the 28th (Mon) so you can travel to Machu Picchu.

Things to do in Cusco

Historic Sites · Spas · Outdoors · Wildlife

Side Trip

Machu Picchu, Peru

— 1 night
A symbol of the Incan civilization, the abandoned city of Machu Picchu represents a must-see on a Peru vacation.
Kick off your visit on the 28th (Mon): stroll through Jardin Botanico en Machu Pichu, then stop by Artesanias, and then take your sightseeing to a higher altitude at Phutuq K'usi. Get ready for a full day of sightseeing on the 29th (Tue): steep yourself in history at Santuario Historico de Machu Picchu and then take some stellar pictures from Intipuncu.

For traveler tips, more things to do, where to stay, and tourist information, read Machu Picchu trip planner.

You can do a combination of bus and train from Cusco to Machu Picchu in 4 hours. Other options are to take a train; or drive. Cap off your sightseeing on the 29th (Tue) early enough to go by car to Nazca.

Things to do in Machu Picchu

Historic Sites · Parks · Wildlife · Nature

Nazca, Peru

— 2 nights
The southern city of Nazca draws visitors to its archaeological and historical sites.
On the 30th (Wed), explore the different monuments and memorials at Cementerio Chauchilla, then examine the collection at Líneas de Cantalloc Telar, and then see the sky in a new way at Planetario Maria Reiche. Get ready for a full day of sightseeing on the 1st (Thu): explore the ancient world of Cahuachi, then head outdoors with Lomas de Marcona y Punta San Fernando, and then make a trip to Nasca Lines.

To see reviews, photos, and other tourist information, you can read our Nazca travel route planner.

You can drive from Machu Picchu to Nazca in 12.5 hours. Another option is to do a combination of taxi and bus. Cap off your sightseeing on the 2nd (Fri) early enough to travel to Huacachina.

Things to do in Nazca

Outdoors · Historic Sites · Museums · Childrens Museums

Huacachina, Peru

— 1 night
Plan my trip to Huacachina with suggested itineraries provided by Inspirock.

Traveling by car from Nazca to Huacachina takes 3 hours. Expect a daytime high around 23°C in July, and nighttime lows around 15°C. You will leave for Lima on the 3rd (Sat).

Things to do in Huacachina

Tours · Outdoors · Wildlife

Lima, Peru

— 2 nights

City of the Kings

Founded in 1535 by Spanish explorer Francisco Pizarro, Lima represents an interesting blend of modern attractions and preserved colonial architecture, much of it clustered in the World Heritage-listed city center.
Start off your visit on the 4th (Sun): delve into the distant past at Huaca Pucllana, then take in the dramatic natural features at Marcahuasi, then contemplate in the serene atmosphere at San Pedro Church (Iglesia de San Pedro), and finally contemplate in the serene atmosphere at Church and Sanctuary of Saint Rose of Lima. On your second day here, walk around Nor Yauyos-Cochas Landscape Reserve, then appreciate the extensive heritage of Centro Historico de Lima, and then get engrossed in the history at Museo Convento San Francisco y Catacumbas.

For maps, ratings, traveler tips, and more tourist information, use the Lima trip website.

You can drive from Huacachina to Lima in 4.5 hours. In July, daily temperatures in Lima can reach 22°C, while at night they dip to 19°C. Finish your sightseeing early on the 5th (Mon) to allow enough time to travel to Huaraz.

Things to do in Lima

Parks · Historic Sites · Wildlife · Nature

Huaraz, Peru

— 2 nights
One of the main cities in the Peruvian Andes, Huaraz mainly draws those seeking adventure out in the landscape.
On the 6th (Tue), take in the spiritual surroundings of Iglesia La Soledad, then explore the different monuments and memorials at Cementerio General Presbitero Villon, and then hit the best photo ops around with Eco Ice Peru. On the 7th (Wed), you'll have a packed day of sightseeing: tour the pleasant surroundings at Callejon de Conchucos and then head outdoors with Infinite Adventures.

To see photos, other places to visit, and tourist information, read Huaraz holiday builder.

Traveling by flight from Lima to Huaraz takes 3.5 hours. Alternatively, you can drive; or take a bus. Expect somewhat warmer weather when traveling from Lima in July: highs in Huaraz hover around 26°C, while lows dip to 7°C. Wrap up your sightseeing on the 7th (Wed) early enough to drive to Huanchaco.

Things to do in Huaraz

Outdoors · Wildlife · Tours · Parks

Huanchaco, Peru

— 1 night
In a historic town on the famous "Moche Route" tourist circuit, vacations in Huanchaco tend to be as active as they are culturally enriching.
Keep things going the next day: stroll through Playa de Huanchaco and then see the interesting displays at Chan Chan Site Museum.

For photos, ratings, reviews, and tourist information, you can read our Huanchaco vacation planner.

Getting from Huaraz to Huanchaco by car takes about 5 hours. Other options: do a combination of bus and taxi. Traveling from Huaraz in July, you can expect nighttime temperatures to be a bit warmer in Huanchaco, with lows of 19°C. Wrap up your sightseeing on the 9th (Fri) to allow time to travel to Mancora.

Things to do in Huanchaco

Outdoors · Beaches · Parks · Museums

Mancora, Peru

— 2 nights
In a busy little beach town, Mancora tourism industry continues to grow, largely thanks to the sunniest climate of any region in the country.
On the 10th (Sat), kick back and relax at Las Pocitas Beach and then soothe aching muscles at some of the top local wellness centers. On your second day here, get up close to creatures of the deep with a dolphin and whale watching tour.

For traveler tips, ratings, where to stay, and more tourist information, refer to the Mancora attractions planning app.

You can do a combination of flight and bus from Huanchaco to Mancora in 7.5 hours. Alternatively, you can drive; or do a combination of taxi and bus. Prepare for a bit warmer weather when traveling from Huanchaco in July: high temperatures in Mancora hover around 30°C and lows are around 23°C. On the 11th (Sun), wrap the sightseeing up by early afternoon so you can travel to Guayaquil.

Things to do in Mancora

Outdoors · Wildlife · Tours · Beaches

Side Trip

Guayaquil, Ecuador

— 3 nights

Pearl of the Pacific

Hills dotted with colorful houses and waterfront promenades typify Guayaquil, Ecuador's largest city and commercial center.
Start off your visit on the 12th (Mon): take in the spiritual surroundings of Iglesia San Francisco and then get a taste of life in the country at Hacienda La Danesa. On the 13th (Tue), you'll have a packed day of sightseeing: appreciate the extensive heritage of Santa Ana Port, then pause for some serene contemplation at Catedral Metropolitana de Guayaquil, then visit Cerro Santa Ana, and finally wander the streets of Las Penas.

For more things to do, photos, traveler tips, and tourist information, you can read our Guayaquil trip tool.

Drive from Mancora to Guayaquil in 6.5 hours. Traveling from Mancora in July, you will find days in Guayaquil are somewhat warmer (34°C), and nights are about the same (25°C). You will leave for home on the 14th (Wed).

Things to do in Guayaquil

Historic Sites · Neighborhoods

Argentina travel guide

4.4
Landmarks · Bodies of Water · Specialty Museums
Land of Contrasts
Home to the highest and lowest points in South America, diverse Argentina enthralls visitors with its contrasting landscapes and rich cultural heritage. A tour of Argentina reveals a sprawling land of fiercely proud and hardworking gauchos, the legendary cowboys of South America's pampas. A vacation in Argentina also leads you to giant urban centers, filled with modern tourist attractions that include fine restaurants, award-winning museums, and renowned public parks, gardens, and zoos. Away from big cities, Argentina sightseeing combines visits to mighty waterfalls situated inside World Heritage-listed national parks in the north of the country, with excursions to icy glaciers in the south.

Bolivia travel guide

4.2
Landmarks · Geologic Formations · Specialty Museums
Tibet of the Americas
If you're an adventurous tourist, consider adding a Bolivia vacation to your travel itinerary. A land of rainforests, Andean glaciers, high altitude cities, and rushing rivers, Bolivia remains one of the most remote countries in the Western Hemisphere. With 60 percent of the population made up of indigenous peoples, native cultures permeate thecountry's music, architecture, and arts, as well as local folklore and traditions. Traveling in Bolivia you can experience diverse wildlife and ecosystems, learn about the country's rich history, try out its distinctive cuisine, and practice your Spanish with the locals, known for their clean and easy-to-understand accent.

Peru travel guide

4.6
Historic Sites · Parks · Landmarks
Land of the Incas
In a country renowned for its pre-Columbian archeological sites, no Peru vacation would be complete without an adrenaline-inducing hike to Machu Picchu, World Heritage-listed symbol of the once-mighty Incan Empire. Aside from visiting these spectacular ruins set against the backdrop of photogenic mountain peaks, most holidays in Peru also include an exploration of the country's pretty cities, boasting well-preserved colonial architecture and a slew of modern buildings housing fine museums, galleries, shops, and restaurants. Ideal for active vacationers, Peru trips are also tailor-made for gourmands, as the country's eclectic cuisine blends tasty influences from Africa, Asia, and Europe.

Ecuador travel guide

4.5
Landmarks · Sacred & Religious Sites · History Museums
With abundant opportunities to discover fascinating World Heritage Sites, a holiday in Ecuador remains among the most culturally enriching travel experiences. Home to the world's highest active volcano, this little country packs a big punch when it comes to tourist activities. Some of the most popular things to do in Ecuador include visits to its astonishingly biodiverse wilderness areas, home to some 1,500 bird species, 840 species of amphibians and reptiles, and nearly 20,000 plant species. Of course, the highlight of many Ecuador vacations is bound to be the Galapagos Islands, made famous by naturalist Charles Darwin. Aside from the stunning nature, Ecuador also boasts many historic cities filled with photogenic colonial-era churches, mansions, and plazas.