45 days in South America & Mexico Itinerary

45 days in South America & Mexico Itinerary

Created using Inspirock attractions planner

Make it your trip
Fly
1
Rio de Janeiro, Brazil
— 5 nights
Bus to Conceição de Jacareí, Ferry to Ilha Grande
2
Ilha Grande, Brazil
— 3 nights
Ferry to Angra dos Reis, Drive to Paraty
3
Paraty, Brazil
— 3 nights
Bus to Rodoviaria, Fly to Foz do Iguacu
4
Foz do Iguacu, Brazil
— 3 nights
Shuttle to Iguazu, Fly to Buenos Aires Jorge Newbery
5
Buenos Aires, Argentina
— 4 nights
Fly
6
Cusco, Peru
— 2 nights
Bus to Ollantaytambo, Train to Machu Picchu
7
Machu Picchu, Peru
— 3 nights
Fly
8
Bogota, Colombia
— 4 nights
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San Andres Island, Colombia
— 4 nights
Fly
10
Tulum, Mexico
— 5 nights
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Mexico City, Mexico
— 3 nights
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Rio de Janeiro, Brazil

— 5 nights

Marvelous City

Bustling with samba music and all-night street parties, no city encapsulates the spirit of Brazil better than Rio de Janeiro.
Appreciate the collections at Museu Historico do Exercito e Forte de Copacabana and Museu do Amanha. Your inner history buff will appreciate Parque Lage and The Metropolitan Cathedral of Saint Sebastian. There's still lots to do: kick back and relax at Copacabana Beach, don't miss a visit to Escadaria Selaron, stroll through Praia de Ipanema, and trek along Pedra da Gavea.

Plan trip to Rio de Janeiro with our itinerary maker to find out where to go and what to do.

London, UK to Rio de Janeiro is an approximately 15.5-hour flight. The time zone changes from Greenwich Mean Time (GMT) to Brasilia Standard Time (BRT), which is usually a -3 hour difference. Traveling from London in October, expect Rio de Janeiro to be warmer, temps between 32°C and 24°C. Cap off your sightseeing on the 17th (Sun) early enough to travel to Ilha Grande.

Things to do in Rio de Janeiro

Parks · Outdoors · Beaches · Museums

Ilha Grande, Brazil

— 3 nights
A tumultuous and unsavory history has kept Ilha Grande relatively undeveloped and free of the trappings of the modern world.
Get some historical perspective at Aqueduto and Igreja de Sao Sebastiao. We've included these beaches for you: Saco do Ceu Beach and Lopes Mendes Beach. There's still lots to do: enjoy the sand and surf at Crena Beach, stroll through Santo Antonio Beach, and contemplate the waterfront views at Lagoa Verde, Ilha Grande.

For ratings, traveler tips, photos, and other tourist information, go to the Ilha Grande tour itinerary planner.

Getting from Rio de Janeiro to Ilha Grande by combination of bus and ferry takes about 5 hours. Other options: do a combination of train, bus, and ferry. In October, daily temperatures in Ilha Grande can reach 33°C, while at night they dip to 23°C. Finish your sightseeing early on the 20th (Wed) so you can travel to Paraty.

Things to do in Ilha Grande

Parks · Outdoors · Beaches · Historic Sites

Paraty, Brazil

— 3 nights
Gazing out over a bay of tiny tropical islands, with rainforests climbing mountains in the background, it's easy to see why tourism in Paraty gets more popular by the year.
Museum-lovers will get to explore Museu Forte Defensor Perpetuo de Paraty and Casa da Cultura de Paraty. Escape the urban bustle at Centro Historico and Jabaquara Beach. And it doesn't end there: admire the sheer force of Cachoeira do Toboga, view the masterpieces at Fabio Marqui Arte, browse the exhibits of Galeria Aecio Sarti, and sample the fine beverages at Alambique Cachaca Pedra Branca.

For maps, where to stay, other places to visit, and more tourist information, read Paraty route maker app.

Getting from Ilha Grande to Paraty by combination of ferry and car takes about 3 hours. Other options: do a combination of ferry and bus. Wrap up your sightseeing by early afternoon on the 23rd (Sat) to allow time for travel to Foz do Iguacu.

Things to do in Paraty

Parks · Museums · Shopping · Outdoors

Foz do Iguacu, Brazil

— 3 nights

Land of the Waterfalls

A gateway to the world-renowned Iguacu Falls, which spectacularly divide Brazil and Argentina, the modern, high-rise city of Foz do Iguacu can't help but play second fiddle to the natural wonder in its vicinity.
Your cultural itinerary includes sights like Buddhist Temple and Marco Das Tres Fronteiras. Appreciate the collections at Itaipu Ecomuseu and Museu de Cera Dreamland. There's lots more to do: learn about wildlife with up-close encounters at Parque das Aves Bird Park, see the world from above with a helicopter tour, identify plant and animal life at Bela Vista Biological Refuge, and surround yourself with nature on a nature and wildlife tour.

To see more things to do, photos, other places to visit, and other tourist information, go to the Foz do Iguacu trip itinerary planning website.

Traveling by combination of bus and flight from Paraty to Foz do Iguacu takes 10 hours. Alternatively, you can drive; or take a bus. Expect a daytime high around 34°C in October, and nighttime lows around 20°C. Wrap up your sightseeing by early afternoon on the 27th (Wed) to allow time for travel to Buenos Aires.

Things to do in Foz do Iguacu

Wildlife · Parks · Outdoors · Tours

Buenos Aires, Argentina

— 4 nights

Queen of La Plata

Cultural capital of South America, Buenos Aires remains one of the largest cities on the continent, serving as a point of departure for exploring the rest of the country.
Cemiterio de Recoleta and Plaza de Mayo will appeal to history buffs. Get a sense of the local culture at Puerto Madero and Museo Nacional de Bellas Artes. There's lots more to do: get to know the fascinating history of La Boca, take an in-depth tour of El Zanjon de Granados, take in the exciting artwork at Karina Chavin Espacio De Arte, and explore the world behind art at Coleccion de Arte Amalia Lacroze de Fortabat.

To see photos, reviews, more things to do, and other tourist information, use the Buenos Aires trip planner.

You can do a combination of shuttle and flight from Foz do Iguacu to Buenos Aires in 5.5 hours. Alternatively, you can drive; or take a bus. Expect little chillier temperatures when traveling from Foz do Iguacu in October; daily highs in Buenos Aires reach 24°C and lows reach 17°C. Finish up your sightseeing early on the 31st (Sun) so you can travel to Cusco.

Things to do in Buenos Aires

Historic Sites · Neighborhoods · Museums · Shopping

Cusco, Peru

— 2 nights

Imperial City

Capital of the Inca Empire for three centuries, World Heritage-listed Cusco is now a major tourist destination, drawing nearly 2 million annual tourists with its well-preserved colonial architecture and proximity to Machu Picchu.
Start off your visit on the 1st (Mon): steep yourself in history at Sacsayhuaman, explore the world behind art at Museo de Arte Precolombino, then admire the masterpieces at Ekekos San Blas - Arte & Colores, and finally steep yourself in history at Plaza de Armas. Get ready for a full day of sightseeing on the 2nd (Tue): get a dose of the wild on a nature and wildlife tour.

Before you visit Cusco, use our trip planner to discover what you can do and see there.

Getting from Buenos Aires to Cusco by flight takes about 10 hours. Other options: drive; or take a bus. You'll gain 2 hours traveling from Buenos Aires to Cusco due to the time zone difference. Traveling from Buenos Aires in October, Cusco is a bit cooler at night with lows of 7°C. Finish your sightseeing early on the 2nd (Tue) so you can travel to Machu Picchu.

Things to do in Cusco

Outdoors · Tours · Wildlife · Historic Sites

Machu Picchu, Peru

— 3 nights
A symbol of the Incan civilization, the abandoned city of Machu Picchu represents a must-see on a Peru vacation.
Start off your visit on the 3rd (Wed): contemplate the long history of Santuario Historico de Machu Picchu and then indulge in some personalized pampering at Otto's Salon Spa & Boutique. Get ready for a full day of sightseeing on the next day: take in nature's colorful creations at Mandor, delve into the distant past at Winay Wayna, and then get great views at Intipuncu.

For photos, where to stay, maps, and more tourist information, read Machu Picchu road trip planning website.

Traveling by combination of bus and train from Cusco to Machu Picchu takes 4 hours. Alternatively, you can take a train; or drive. On the 5th (Fri), wrap the sightseeing up by early afternoon so you can travel to Bogota.

Things to do in Machu Picchu

Historic Sites · Parks · Nature · Spas

Bogota, Colombia

— 4 nights

Athens of South America

Colombia's heart and soul, Bogota has earned the nickname "Athens of South America" thanks to its abundance of universities, libraries, and lower-level schools.
Popular historic sites such as Catedral de Sal de Zipaquira and Iglesia de Nuestra Senora de los Dolores are in your itinerary. Get outdoors at Laguna de Guatavita and Dive & Tours. You'll find plenty of places to visit near Bogota: Centro de Memoria El Cuartico (in Valledupar), Esensal (in Zipaquira) and Iglesia de Nuestra Senora de Fatima (in Tocancipa). There's still lots to do: examine the collection at Gold Museum (Museo del Oro), admire the masterpieces at Museo Botero del Banco de la Republica, pause for some serene contemplation at Parroquia Santa Helena, and take in the awesome beauty at Monserrate.

To find ratings, more things to do, other places to visit, and more tourist information, read Bogota online itinerary planner.

Fly from Machu Picchu to Bogota in 11 hours. Alternatively, you can drive; or do a combination of car and bus. Expect a daytime high around 22°C in November, and nighttime lows around 10°C. Finish up your sightseeing early on the 10th (Wed) so you can travel to San Andres Island.

Things to do in Bogota

Parks · Nature · Wildlife · Historic Sites

Side Trips

San Andres Island, Colombia

— 4 nights
The coral San Andres Island boasts a rich colonial history, exotic beaches, and a laidback, tropical lifestyle.
Visiting Scuba San Andres Dive Shop and Johnny Cay will get you outdoors. You'll get in some beach time at Playa de Spratt Bight and Playa Charquitos. There's still lots to do: identify plant and animal life at La Piscinita, explore the gorgeous colors at West View, stop by Esmeraldas Colombianas, and head off the coast to Cayo El Acuario.

Plan my trip to San Andres Island with suggested itineraries provided by Inspirock.

Fly from Bogota to San Andres Island in 4.5 hours. Expect a bit warmer weather when traveling from Bogota in November: highs in San Andres Island hover around 35°C, while lows dip to 29°C. Wrap up your sightseeing by early afternoon on the 15th (Mon) to allow time for travel to Tulum.

Things to do in San Andres Island

Parks · Outdoors · Wildlife · Nature

Tulum, Mexico

— 5 nights
The only Mayan site built to overlook the ocean, Tulum remains a coastal paradise preserving the last vestiges of a pre-Hispanic civilization.
Your cultural itinerary includes sights like Tulum Archaeological Site and Balam Art On Feathers. Deepen your sense of the past at sights like Chichen Itza and Temple of the Bearded Man. Venture out of the city with trips to Cobá Zona Arqueológica Cobá (in Coba), The Ossuary (in Chichen Itza) and Sian Ka'an Biosphere Reserve (in Sian Ka'an). The adventure continues: enjoy the sand and surf at Paradise Beach, indulge in some personalized pampering at some of the best spas, admire the landmark architecture of Sfer IK, and find your balance on the water with some of the best stand-up paddleboarding in the area.

To find reviews, where to stay, maps, and more tourist information, read Tulum travel planner.

Traveling by flight from San Andres Island to Tulum takes 12 hours. Traveling from San Andres Island in November, expect Tulum to be slightly colder, temps between 32°C and 24°C. Wrap up your sightseeing on the 21st (Sun) to allow time to travel to Mexico City.

Things to do in Tulum

Parks · Outdoors · Historic Sites · Beaches

Side Trips

Mexico City, Mexico

— 3 nights

City of Palaces

Breathtakingly large, Mexico City provides a home for almost 9 million people living in nearly 1,700 distinct neighborhoods.
Appreciate the collections at Museo Nacional de Antropologia and Museo Frida Kahlo. Get some cultural insight at Palacio de Bellas Artes and Museo del Templo Mayor. Next up on the itinerary: contemplate in the serene atmosphere at Metropolitan Cathedral (Catedral Metropolitana), wander the streets of Historic Center (Centro Historico), examine the collection at Museo del Tiempo Tlalpan, and stop by Coyoacan.

To find maps, where to stay, more things to do, and more tourist information, use the Mexico City route planner.

Traveling by flight from Tulum to Mexico City takes 6 hours. Alternatively, you can drive; or take a bus. Due to the time zone difference, you'll gain 1 hour traveling from Tulum to Mexico City. When traveling from Tulum in November, plan for slightly colder days in Mexico City, with highs around 26°C, while nights are colder with lows around 11°C. Finish your sightseeing early on the 24th (Wed) to allow enough time to travel back home.

Things to do in Mexico City

Historic Sites · Museums · Neighborhoods · Parks

Peru travel guide

4.6
Historic Sites · Parks · Landmarks
Land of the Incas
In a country renowned for its pre-Columbian archeological sites, no Peru vacation would be complete without an adrenaline-inducing hike to Machu Picchu, World Heritage-listed symbol of the once-mighty Incan Empire. Aside from visiting these spectacular ruins set against the backdrop of photogenic mountain peaks, most holidays in Peru also include an exploration of the country's pretty cities, boasting well-preserved colonial architecture and a slew of modern buildings housing fine museums, galleries, shops, and restaurants. Ideal for active vacationers, Peru trips are also tailor-made for gourmands, as the country's eclectic cuisine blends tasty influences from Africa, Asia, and Europe.

Colombia travel guide

4
Historic Sites · Landmarks · Specialty Museums
Diverse in terms of landscapes, climates, and cultures, Colombia remains one of South America's least explored tourist destinations, overshadowed by its more popular southern neighbors. Combining the best of what the continent has to offer, a vacation in Colombia allows you to blend outdoor adventures with tours of picture-perfect cobblestoned towns dating back to the colonial era. Tourists on a Colombia holiday can easily hop from sun-kissed coastal spots to the hilly coffee-growing region, where thriving plantations quickly give way to a landscape of snow-covered volcanic peaks and the paramo--alpine ecosystems sheltering some of the rarest plants growing above the continuous forest line.

Mexico travel guide

4.5
Ruins · Beaches · Landmarks
Tailor-made for anyone seeking that traditional sun-and-sand experience, Mexico vacations allow visitors to explore nearly 10,000 km (6,200 mi) of picturesque coastlines. Idyllic beaches and favorable year-round weather aside, this diverse country with a rich pre-Colombian history allows tourists a chance to discover a fascinating cuisine, numerous archaeological sites, state-of-the-art museums, colonial-era haciendas, and outstanding examples of 21st-century architecture. Most visitors get to know the country by its cities, but if you want a well-rounded Mexico tour, spend some time exploring its jungles, cloud forests, Caribbean reefs, snowcapped volcanoes, vast deserts, and tranquil lagoons. Life is lived outdoors in Mexico, so wherever you go, don't forget to dine alfresco and stroll the country's colonial streets.