45 days in South America & Central America Itinerary

45 days in South America & Central America Itinerary

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Route & dates

45 days in South America & Central America Itinerary

Start: Paris, France
Fly:  18​h 30​min
1
Arequipa, Peru
— 2 nights
Drive:  7​h
2
Nazca, Peru
— 4 nights
+2
bus + taxi + Fly:  6​h 15​min
3
Cusco, Peru
— 6 nights
Fly:  5​h 30​min
4
Quito, Ecuador
— 5 nights
+3
Fly + shuttle + ferry + bus:  5​h
5
Puerto Ayora, Ecuador
— 2 nights
ferry:  2​h 30​min
6
Puerto Villamil, Ecuador
— 2 nights
+4
Fly + foot + Fly + taxi + bus:  8​h
7
Banos, Ecuador
— 2 nights
+2
bus + taxi + Fly:  11​h
8
Santa Marta, Colombia
— 2 nights
shuttle + Fly:  3​h
9
San Andres Island, Colombia
— 3 nights
Fly:  1​h 45​min
10
Panama City, Panama
— 5 nights
Fly:  2​h
11
Cartagena, Colombia
— 7 nights
Fly:  14​h
End: Paris, France

2
nights
Arequipa, Peru

Arequipa ©
In an area dominated three imposing volcanoes, Arequipa vacations allow visitors to admire well-preserved colonial architecture in a dramatic setting.
Attractions like Zoomundo and Playa los Arcos make great kid-friendly stops. Explore hidden gems such as Iglesia de Yanahuara ( San Juan Bautista) and Chachani. There's much more to do: take a tour by water with Boat Tours & Water Sports, explore the engaging exhibits at FBC Melgar, stop by La Iberica, and see the interesting displays at MUVI Museo Vivencial del Vino y Pisco.

For reviews, more things to do, ratings, and more tourist information, refer to the Arequipa online trip builder .

Paris, France to Arequipa is an approximately 18.5-hour flight. You can also do a combination of train and flight; or do a combination of flight and bus. You'll gain 6 hours traveling from Paris to Arequipa due to the time zone difference. Traveling from Paris in June, expect little chillier with lows of 9°C in Arequipa. Finish your sightseeing early on the 20th (Sat) to allow enough time to drive to Nazca.

Things to do in Arequipa

Parks Outdoors Adventure
Highlights from your plan
Zoomundo ©
Zoomundo
FBC Melgar ©
FBC Melgar

4
nights
Nazca, Peru

Nazca ©
The southern city of Nazca draws visitors to its archaeological and historical sites.
Family-friendly places like Playa Trompa de Elefante and Casa del Inka - Museo Incawasi will thrill your kids. You'll discover tucked-away gems like Cahuachi and Casa-Museo Mari Reiche. Next up on the itinerary: explore the different monuments and memorials at Cementerio Chauchilla, see the interesting displays at Líneas de Cantalloc Telar, don't miss a visit to Ceramicas LASC, and delve into the distant past at Cantalloc Aqueduct.

To see ratings, other places to visit, maps, and tourist information, read our Nazca travel itinerary planner .

Traveling by car from Arequipa to Nazca takes 7 hours. Alternatively, you can take a bus; or do a combination of flight and bus. Finish your sightseeing early on the 24th (Wed) to allow enough time to travel to Cusco.

Things to do in Nazca

Historic Sites Museums Parks

Side Trip

Playa Trompa de Elefante
Highlights from your plan
Cementerio Chauchilla ©
Cementerio Chauchilla
Cahuachi ©
Cahuachi
Cantalloc Aqueduct ©
Cantalloc Aqueduct

6
nights
Cusco, Peru

Capital of the Inca Empire for three centuries, World Heritage-listed Cusco is now a major tourist destination, drawing nearly 2 million annual tourists with its well-preserved colonial architecture and proximity to Machu Picchu.
You'll discover tucked-away gems like Horseback Riding Tours and Spas. You'll find plenty of places to visit near Cusco: Moray (in Maras) and Pisac (in Pisac). And it doesn't end there: contemplate the long history of Sacred Valley of the Incas, admire the landmark architecture of Iglesia de la Compania de Jesus, stroll through Santuario Animal de Cochahuasi, and get a new perspective on things with Boat Tours & Water Sports.

For ratings, reviews, maps, and more tourist information, read our Cusco route planning tool .

Traveling by combination of bus and flight from Nazca to Cusco takes 6.5 hours. Alternatively, you can take a bus; or drive. June in Cusco sees daily highs of 24°C and lows of 1°C at night. Finish up your sightseeing early on the 30th (Tue) so you can travel to Quito.

Things to do in Cusco

Tours Outdoors Historic Sites

Side Trips

Moray, Pisac, Sacred Valley of the Incas
Highlights from your plan
Horseback Riding Tours
Moray ©
Moray
Spas

5
nights
Quito, Ecuador

Quito ©
High in the Andean foothills, Quito remains one of the world's most photogenic capital cities, featuring two dramatic mountain ranges as its backdrop.
Explore hidden gems such as Food Tours and Intinan Museum. You'll find plenty of places to visit near Quito: Cascada de Peguche (in Peguche) and Cuicocha (in Cotacachi). Spend the 4th (Sat) among the fascinating landscape of Cotopaxi National Park. Next up on the itinerary: explore the world behind art at La Capilla Del Hombre, contemplate in the serene atmosphere at Basilica del Voto Nacional, walk around Parque Bulevar 24 de Mayo, and don't miss a visit to Mitad Del Mundo.

To find where to stay, reviews, ratings, and tourist information, read our Quito vacation builder tool .

Fly from Cusco to Quito in 5.5 hours. Alternatively, you can drive; or take a bus. Traveling from Cusco in June, plan for warmer nights in Quito, with lows around 17°C. Wrap up your sightseeing on the 5th (Sun) early enough to travel to Puerto Ayora.

Things to do in Quito

Parks Nature Historic Sites

Side Trips

Cascada de Peguche, Cuicocha, Cotopaxi National Park
Highlights from your plan
Cuicocha ©
Cuicocha
Food Tours
Intinan Museum ©
Intinan Museum

2
nights
Puerto Ayora, Ecuador

Puerto Ayora ©
The largest settlement in the Galapagos, Puerto Ayora offers visitors to the islands an array of facilities and things to do.
On the 6th (Mon), stroll through El Chato - Giant Tortoise Reserve, view the masterpieces at The Angelique Art Gallery, then kick back and relax at Galapagos Beach at Tortuga Bay, and finally make a trip to Santa Cruz Fish Market. Keep things going the next day: tour the pleasant surroundings at El Garrapatero, then tour the pleasant surroundings at Black Turtle Cove, then make a trip to Malecon de Puerto Ayora, and finally take in the dramatic natural features at Las Grietas.

Make your Puerto Ayora itinerary with Inspirock to find out what to see and where to go.

Getting from Quito to Puerto Ayora by combination of flight, ferry, and bus takes about 5 hours. In July, Puerto Ayora is somewhat warmer than Quito - with highs of 31°C and lows of 25°C. Finish up your sightseeing early on the 7th (Tue) so you can catch the ferry to Puerto Villamil.

Things to do in Puerto Ayora

Parks Outdoors Beaches

Side Trip

Santa Cruz
Highlights from your plan
El Garrapatero ©
El Garrapatero
Galapagos Beach at Tortuga Bay ©
Galapagos Beach at Tortuga Bay
El Chato - Giant Tortoise Reserve ©
El Chato - Giant Tortoise Reserve

2
nights
Puerto Villamil, Ecuador

Puerto Villamil ©
Located in the southeast of Isla Isabela, Puerto Villamil is home to the majority of the island's 2,200 inhabitants.
Start off your visit on the 8th (Wed): stroll through Playa Puerto Villamil and then head off the coast to Las Tintoreras. On the 9th (Thu), you'll have a packed day of sightseeing: explore the activities along Laguna de los Diablos, make a trip to The Wall of Tears, get to know the resident critters at Centro de Crianza Tortugas Gigantes Arnaldo Tupiza Chamaidan, then take in the architecture and atmosphere at Iglesia Cristo Salvador, and finally tour the pleasant surroundings at Concha de Perla.

To see more things to do, ratings, photos, and other tourist information, use the Puerto Villamil trip itinerary tool .

You can ride a ferry from Puerto Ayora to Puerto Villamil in 2.5 hours. The time zone difference when traveling from Puerto Ayora to Puerto Villamil is minus 1 hour. Finish your sightseeing early on the 9th (Thu) to allow enough time to travel to Banos.

Things to do in Puerto Villamil

Parks Nature Zoos & Aquariums
Highlights from your plan
Las Tintoreras ©
Las Tintoreras
Concha de Perla ©
Concha de Perla

2
nights
Banos, Ecuador

A trip to Banos, a relatively small town in the picturesque Andean highlands, ensures plenty of chances for outdoor activities like horseback riding, hiking, climbing, canyoning, and mountain biking.
Step off the beaten path and head to Pailon del Diablo (Devil's Cauldron) and Parasailing & Paragliding. There's lots more to do: explore the landscape on two wheels at Ruta de las cascadas, take some stellar pictures from La Casa del Arbol, get in on the family fun at Discovery Banos, and skim along the rocks with a canyoning and rapelling tour.

To see more things to do, reviews, photos, and more tourist information, you can read our Banos road trip planner.

You can do a combination of flight and bus from Puerto Villamil to Banos in 8 hours. Another option is to do a combination of flight and bus. You'll lose 1 hour traveling from Puerto Villamil to Banos due to the time zone difference. Finish your sightseeing early on the 12th (Sun) so you can travel to Santa Marta.

Things to do in Banos

Outdoors Tours Adventure
Highlights from your plan
Parasailing & Paragliding
Discovery Banos ©
Discovery Banos
Pailon del Diablo (Devil's Cauldron) ©

2
nights
Santa Marta, Colombia

Santa Marta ©
Many visitors begin their Santa Marta holiday, surrounded by urban clutter and heavy traffic, expecting little from the city in terms of historical importance.
You'll discover tucked-away gems like Cristal Beach and Playa Blanca. There's still lots to do: admire the masterpieces at Quinta de San Pedro Alejandrino, take a tour by water with Boat Tours & Water Sports, stroll around Parque de Los Novios, and get a sense of history and politics at Alcaldia de Santa Marta.

For traveler tips, maps, where to stay, and more tourist information, go to the Santa Marta trip planner .

Getting from Banos to Santa Marta by combination of bus and flight takes about 11 hours. Other options: do a combination of bus and flight; or drive. In July, daytime highs in Santa Marta are 39°C, while nighttime lows are 30°C. Wrap up your sightseeing on the 15th (Wed) early enough to travel to San Andres Island.

Things to do in Santa Marta

Parks Outdoors Beaches
Highlights from your plan
Cristal Beach ©
Cristal Beach
Playa Blanca ©
Playa Blanca
Rodadero Sea Aquarium and Museum ©
Rodadero Sea Aquarium and Museum

3
nights
San Andres Island, Colombia

San Andres Island ©
The coral San Andres Island boasts a rich colonial history, exotic beaches, and a laidback, tropical lifestyle.
Family-friendly places like Playa de Spratt Bight and Playa Charquitos will thrill your kids. Eschew the tourist crowds and head to Rocky Cay and Scuba & Snorkeling. And it doesn't end there: see the vivid underwater world at West View, identify plant and animal life at La Piscinita, step off the mainland to explore Cayo Bolivar, and get impressive views of El Totumo Volcon.

For ratings, reviews, photos, and more tourist information, you can read our San Andres Island trip itinerary planner .

You can do a combination of shuttle and flight from Santa Marta to San Andres Island in 3 hours. Alternatively, you can do a combination of bus and flight. When traveling from Santa Marta in July, plan for little chillier days and about the same nights in San Andres Island: temperatures range from 35°C by day to 29°C at night. Wrap up your sightseeing on the 18th (Sat) to allow time to travel to Panama City.

Things to do in San Andres Island

Parks Wildlife Outdoors

Side Trip

El Totumo Volcon
Highlights from your plan
Cayo El Acuario ©
Cayo El Acuario
Playa de Spratt Bight ©
Playa de Spratt Bight
Rocky Cay ©
Rocky Cay

5
nights
Panama City, Panama

Panama City ©
Arguably the most modern of Central American cities, Panama City boasts a shimmering skyline of glass skyscrapers.
Discover out-of-the-way places like Avenida Balboa and Ancon Hill. Explore the numerous day-trip ideas around Panama City: Gatun Locks (in Colon) and Chorro de La Chorrera (in La Chorrera). There's still lots to do: wander the streets of Cinta Costera, explore the activities along Gatun Lake, buy something for everyone on your list at Multiplaza Pacific, and try to win big at Crown Casino El Panama.

To see other places to visit, ratings, traveler tips, and other tourist information, go to the Panama City online tour planner .

You can fly from San Andres Island to Panama City in 2 hours. In July, daytime highs in Panama City are 36°C, while nighttime lows are 29°C. Wrap up your sightseeing on the 23rd (Thu) early enough to travel to Cartagena.

Things to do in Panama City

Historic Sites Neighborhoods Museums

Side Trips

Chorro de La Chorrera, Gatun Locks
Highlights from your plan
Avenida Balboa ©
Avenida Balboa
Cinta Costera ©
Cinta Costera
Panama La Vieja ©
Panama La Vieja

7
nights
Cartagena, Colombia

Cartagena ©
The site of the continent's first Spanish colony, Cartagena retains much of its colonial flavor thanks to a World Heritage-listed old town, encircled by old walls and protected by imposing fortresses.
You'll visit kid-friendly attractions like Playa Puntilla and Playa de Bocagrande. Discover out-of-the-way places like Aviario Nacional de Colombia and Food Tours. Step out of Cartagena to go to Puerto Colombia and see Castillo de Salgar, which is approximately 1h 55 min away. Spend a day outdoors on the 30th (Thu) with Bomba Beach Club. The adventure continues: take a stroll through Barrio Getsemani, make a trip to Plaza de La Trinidad, hit the best photo ops around with an inspiring photography tour, and appreciate the history behind La Gorda Gertrudis.

To see more things to do, where to stay, other places to visit, and tourist information, use the Cartagena trip maker tool .

Traveling by flight from Panama City to Cartagena takes 2 hours. In July, daily temperatures in Cartagena can reach 38°C, while at night they dip to 30°C. Wrap up your sightseeing on the 30th (Thu) to allow time to travel back home.

Things to do in Cartagena

Historic Sites Neighborhoods Outdoors

Side Trips

Isla Baru, Castillo de Salgar
Highlights from your plan
Templo de Santo Domingo ©
Templo de Santo Domingo
Playa de Bocagrande ©
Playa de Bocagrande
Aviario Nacional de Colombia ©
Aviario Nacional de Colombia

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