42 days in South America Itinerary

42 days in South America Itinerary

Created using Inspirock South America Trip Planner

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Route & dates

42 days in South America Itinerary

Start: Pilar, Argentina
Drive:  9​h 30​min
1
San Francisco del Monte de Oro, Argentina
— 2 nights
Drive:  5​h
2
Barreal, Argentina
— 2 nights
Drive:  8​h
3
Fiambala, Argentina
— 1 night
Drive:  8​h 15​min
4
Antofagasta de la Sierra, Argentina
— 3 nights
Drive:  7​h 45​min
5
Cafayate, Argentina
— 1 day
Drive:  3​h 30​min
6
Cachi, Argentina
— 1 night
Drive:  8​h
7
San Pedro de Atacama, Chile
— 2 nights
Drive:  6​h 45​min
8
Iquique, Chile
— 2 nights
Drive:  4​h 45​min
9
Tacna, Peru
— 2 nights
Drive:  5​h 30​min
10
Puno, Peru
— 2 nights
Drive:  5​h 45​min
11
Cusco, Peru
— 2 nights
Drive:  5​h 45​min
12
Machu Picchu, Peru
— 1 night
Drive:  5​h 45​min
13
Cusco, Peru
— 3 nights
Drive:  5​h 30​min
14
Juliaca, Peru
— 2 nights
Drive:  5​h 30​min
15
La Paz, Bolivia
— 2 nights
Drive:  3​h 30​min
16
Oruro, Bolivia
— 2 nights
Drive:  4​h 45​min
17
Uyuni, Bolivia
— 2 nights
Drive:  3​h 15​min
18
Tupiza, Bolivia
— 2 nights
Drive:  5​h 30​min
19
Province of Jujuy, Argentina
— 2 nights
Drive:  5​h 15​min
20
Termas de Rio Hondo, Argentina
— 2 nights
Drive:  7​h 15​min
21
Rafaela, Argentina
— 3 nights
Drive:  5​h 45​min
End: Buenos Aires, Argentina

2
nights
San Francisco del Monte de Oro, Argentina

San Francisco del Monte de Oro
On the 29th (Sat), make a trip to Escuela de San Francisco del Monte de Oro.

To see reviews, ratings, more things to do, and other tourist information, read our San Francisco del Monte de Oro trip planner.

Pilar to San Francisco del Monte de Oro is an approximately 6-hour combination of car and flight. You can also drive. The time zone changes from Argentine Time (ART) to Central Standard Time (CST), which is usually a -3 hour difference. When traveling from Pilar in April, plan for somewhat warmer days in San Francisco del Monte de Oro, with highs around 26°C, while nights are a bit cooler with lows around 13°C. On the 1st (Mon), you'll travel to Barreal.

2
nights
Barreal, Argentina

Barreal ©
Start off your visit on the 1st (Mon): pause for some serene contemplation at Iglesia de Jesus de la Buena Esperanza and then head outdoors with Carrovelismo. Get ready for a full day of sightseeing on the 2nd (Tue): indulge your senses at some of the top wineries in the area and then take your sightseeing to a higher altitude at Alkazar Mountain.

For photos, more things to do, other places to visit, and more tourist information, read Barreal vacation planner.

You can drive from San Francisco del Monte de Oro to Barreal in 6.5 hours. Another option is to do a combination of car and flight. The time zone difference moving from Central Standard Time (CST) to Atlantic Standard Time (AST) is 2 hours. In May, daytime highs in Barreal are 23°C, while nighttime lows are 7°C. Finish up your sightseeing early on the 3rd (Wed) so you can travel to Fiambala.

Things to do in Barreal

Outdoors Nature Parks

Side Trip

Alkazar Mountain
Highlights from your plan

1
night
Fiambala, Argentina

Fiambala ©
Fiambalá is a town in the department of Tinogasta, located in the west part of Catamarca Province, Argentina. On the 3rd (Wed), get outside with Dunes of Taton and then see the interesting displays at Museo del Hombre.

To see ratings, other places to visit, and other tourist information, you can read our Fiambala holiday planner.

You can drive from Barreal to Fiambala in 10 hours. Alternatively, you can do a combination of car and flight. The time zone changes from Atlantic Standard Time to Argentine Time, which is usually a 1 hour difference. Cap off your sightseeing on the 4th (Thu) early enough to travel to Antofagasta de la Sierra.

Things to do in Fiambala

Outdoors Museums
Highlights from your plan
Dunes of Taton ©
Dunes of Taton
Museo del Hombre ©
Museo del Hombre

3
nights
Antofagasta de la Sierra, Argentina

Antofagasta de la Sierra ©
Antofagasta de la Sierra is a village in Catamarca Province, Argentina. Step out of Antofagasta de la Sierra with an excursion to Salar de Antofalla in Antofalla--about 1h 45 min away. And it doesn't end there: contemplate the geological forces at Galan Volcano, examine the collection at Museo Mineralogico de la Puna, and head outdoors with Carachi Pampa.

To find more things to do, reviews, where to stay, and tourist information, go to the Antofagasta de la Sierra trip builder.

You can drive from Fiambala to Antofagasta de la Sierra in 8.5 hours. Finish up your sightseeing early on the 7th (Sun) so you can travel to Cafayate.

Things to do in Antofagasta de la Sierra

Outdoors Nature Parks

Side Trip

Salar de Antofalla
Highlights from your plan
Salar de Antofalla ©
Salar de Antofalla
Volcan Galan ©
Volcan Galan
Carachi Pampa ©
Carachi Pampa

1
day
Cafayate, Argentina

Cafayate ©
Nestled in one of the country's major wine regions, Cafayate and the surrounding area remain a top vacation destination throughout the year.
Kick off your visit on the 8th (Mon): explore the striking landscape at El Anfiteatro, then take in the dramatic natural features at La Garganta del Diablo, then don't miss a visit to Quebrada del Rio de las Conchas, and finally see the interesting displays at Museo de la Vid y el Vino de Cafayate, Salta, Argentina.

To see traveler tips, more things to do, reviews, and other tourist information, you can read our Cafayate travel itinerary planner.

Drive from Antofagasta de la Sierra to Cafayate in 8 hours. Wrap up your sightseeing on the 8th (Mon) to allow time to travel to Cachi.

Things to do in Cafayate

Parks Nature Museums
Highlights from your plan
Quebrada del Rio de las Conchas ©
Quebrada del Rio de las Conchas
Garganta del Diablo Salta ©
Garganta del Diablo Salta
El Anfiteatro ©
El Anfiteatro

1
night
Cachi, Argentina

Cachi ©
Though it's the biggest settlement for miles and locals call it a city, Cachi is really more of a village with a population of just over 2,000.
Kick off your visit on the 9th (Tue): take in the architecture and atmosphere at Cachi Iglesia, then make a trip to Cachi, and then examine the collection at Museo Arqueologico Pio Pablo Diaz.

For maps, more things to do, reviews, and other tourist information, use the Cachi itinerary maker.

Traveling by car from Cafayate to Cachi takes 3.5 hours. In May in Cachi, expect temperatures between 23°C during the day and 10°C at night. Wrap up your sightseeing on the 9th (Tue) early enough to travel to San Pedro de Atacama.

Things to do in Cachi

Museums Historic Sites
Highlights from your plan
Museo Arqueologico Pio Pablo Diaz ©
Cachi ©
Cachi
Cachi Iglesia ©
Cachi Iglesia

2
nights
San Pedro de Atacama, Chile

San Pedro de Atacama ©
Major archeological sites and a renowned museum remain the big draws in San Pedro de Atacama tourism, appealing to visitors interested in learning more about South America's pre-Columbian cultures.
Start off your visit on the 10th (Wed): take in the dramatic natural features at Valle de la Luna - Valle de la Muerte and then witness a stunning natural landmark at Geyser del Tatio. Keep things going the next day: take in the dramatic natural features at Piedras Rojas, then make a trip to Mirador de Kari, Piedra del Coyote, and then explore the ancient world of Pukara de Quitor Ruins.

To find other places to visit, reviews, maps, and other tourist information, read San Pedro de Atacama travel planner.

Traveling by car from Cachi to San Pedro de Atacama takes 8 hours. Alternatively, you can do a combination of car and flight. You'll gain 1 hour traveling from Cachi to San Pedro de Atacama due to the time zone difference. Expect a bit cooler evenings in San Pedro de Atacama when traveling from Cachi in May, with lows around 3°C. Finish up your sightseeing early on the 11th (Thu) so you can go by car to Iquique.

Things to do in San Pedro de Atacama

Nature Parks Historic Sites
Highlights from your plan
Geyser del Tatio ©
Geyser del Tatio
Valle De La Luna ©
Valle De La Luna
Pukara de Quitor ©
Pukara de Quitor

2
nights
Iquique, Chile

Iquique ©
Thanks to the city's position on the Pacific coast, vacations in Iquique appeal to beachgoers, paragliders, bodyboarders, nature lovers, photographers, and fans of picture-perfect sunsets.
On the 12th (Fri), enjoy the sand and surf at Playa Cavancha, then wander the streets of Baquedano Street, then brush up on your military savvy at Museo Corbeta Esmeralda, and finally enjoy the sand and surf at Playa Brava. Get ready for a full day of sightseeing on the next day: mingle with the ghosts of the past at Oficina Salitrera Santiago Humberstone, then see the interesting displays at Salitrera Santa Laura, and then buy something for everyone on your list at Mall Zofri.

For where to stay, reviews, more things to do, and other tourist information, go to the Iquique trip planner.

Traveling by car from San Pedro de Atacama to Iquique takes 7 hours. Alternatively, you can do a combination of bus, taxi, and flight; or take a bus. Traveling from San Pedro de Atacama in May, expect much warmer with lows of 18°C in Iquique. Finish your sightseeing early on the 13th (Sat) so you can travel to Tacna.

Things to do in Iquique

Outdoors Parks Beaches
Highlights from your plan
Playa Cavancha ©
Playa Cavancha
Salitrera Santa Laura ©
Salitrera Santa Laura
Oficina Salitrera Santiago Humberstone ©

2
nights
Tacna, Peru

Tacna ©
Located close to Peru's border with Chile, Tacna stands as the capital of the Tacna Region and represents one of the most populous urban areas in the country.
Kick off your visit on the 14th (Sun): don't miss a visit to Arco Parabolico, don't miss a visit to Paseo Civico, then pause for some serene contemplation at Catedral de Tacna, and finally browse the eclectic array of goods at Mercado Central y Mercadillos de Tacna. On the 15th (Mon), you'll have a packed day of sightseeing: learn about all things military at Museo De Sitio Alto dela Alianza, enjoy the sand and surf at Boca del Rio Beach, then see the interesting displays at Museo Ferroviario, and finally don't miss a visit to Miculla Petroglyphs.

To find where to stay, photos, and tourist information, read our Tacna trip itinerary maker.

Getting from Iquique to Tacna by car takes about 5 hours. The time zone changes from Chile Time to Peru Time, which is usually a -1 hour difference. In May, daily temperatures in Tacna can reach 26°C, while at night they dip to 16°C. Wrap up your sightseeing on the 15th (Mon) to allow time to drive to Puno.

Things to do in Tacna

Outdoors Parks Beaches
Highlights from your plan
Museo Ferroviario ©
Museo Ferroviario
Catedral de Tacna ©
Catedral de Tacna
Arco Parabolico ©
Arco Parabolico

2
nights
Puno, Peru

Puno ©
Hugging the western tip of Lake Titicaca, Puno serves as a melting pot of indigenous and imported cultures, and makes a great base for explorations around the region.
Start off your visit on the 16th (Tue): stroll the grounds of Sillustani and then head off the coast to Taquile Island. On the next day, get great views at Mirador Ing. Eduardo Sanchez, visit a coastal fixture at Lake Titicaca, and then step off the mainland to explore Uros Floating Islands.

For reviews, other places to visit, maps, and more tourist information, use the Puno vacation builder.

You can drive from Tacna to Puno in 5.5 hours. Alternatively, you can do a combination of taxi, flight, and bus. When traveling from Tacna in May, plan for a bit cooler days and much colder nights in Puno: temperatures range from 21°C by day to -2°C at night. Finish up your sightseeing early on the 17th (Wed) so you can travel to Cusco.

Things to do in Puno

Nature Parks Historic Sites
Highlights from your plan
Taquile Island ©
Taquile Island
Uros Floating Islands ©
Uros Floating Islands
Sillustani ©
Sillustani

2
nights
Cusco, Peru

Cusco ©
Capital of the Inca Empire for three centuries, World Heritage-listed Cusco is now a major tourist destination, drawing nearly 2 million annual tourists with its well-preserved colonial architecture and proximity to Machu Picchu.
On the 18th (Thu), hunt for treasures at Mercado Central de San Pedro, see the interesting displays at ChocoMuseo, then take an in-depth tour of Museo Inka, and finally examine the collection at Pre-Columbian Art Museum. Get ready for a full day of sightseeing on the 19th (Fri): let the river carry you with a rafting and tubing tour, delve into the distant past at Tambomachay, and then explore the ancient world of Q'enqo.

For traveler tips, reviews, where to stay, and more tourist information, you can read our Cusco vacation builder.

Traveling by combination of bus, taxi, and flight from Puno to Cusco takes 3.5 hours. Alternatively, you can drive; or take a bus. Traveling from Puno in May, Cusco is a bit warmer at night with lows of 4°C. Wrap up your sightseeing on the 19th (Fri) early enough to travel to Machu Picchu.

Things to do in Cusco

Museums Adventure Tours
Highlights from your plan
ChocoMuseo ©
ChocoMuseo
Museo de Arte Precolombino ©
Museo de Arte Precolombino
Tambomachay ©
Tambomachay

1
night
Machu Picchu, Peru

Machu Picchu ©
A symbol of the Incan civilization, the abandoned city of Machu Picchu represents a must-see on a Peru vacation.
Kick off your visit on the 20th (Sat): stop by Artesanias and then explore the ancient world of Machu Picchu.

To find ratings, where to stay, other places to visit, and tourist information, read Machu Picchu vacation trip planner.

You can do a combination of taxi and train from Cusco to Machu Picchu in 4 hours. Alternatively, you can drive. Wrap up your sightseeing on the 20th (Sat) to allow time to travel to Cusco.

Things to do in Machu Picchu

Historic Sites Shopping
Highlights from your plan
Santuario Historico de Machu Picchu ©
Artesanias ©
Artesanias

3
nights
Cusco, Peru

Cusco ©
Enjoy Cusco some more: delve into the distant past at Sacsayhuaman, take in the architecture and atmosphere at Convento de Santo Domingo, take a stroll through San Blas, and admire the striking features of Centro Historico De Cusco.

To find maps, photos, other places to visit, and tourist information, read our Cusco vacation builder.

Getting from Machu Picchu to Cusco by combination of train and taxi takes about 4 hours. Other options: drive. Finish your sightseeing early on the 23rd (Tue) so you can travel to Juliaca.

Things to do in Cusco

Historic Sites Neighborhoods Nature

Side Trips

Sacred Valley of the Incas, Salinas de Maras
Highlights from your plan
Sacsayhuaman ©
Sacsayhuaman
Plaza de Armas ©
Plaza de Armas
Centro Historico De Cusco ©
Centro Historico De Cusco

2
nights
Juliaca, Peru

Juliaca ©
Juliaca is the capital of San Roman Province in the Puno Region of southeastern Peru. On the 24th (Wed), pause for some serene contemplation at Iglesia Matriz de Santa Catalina and then head off the coast to Isla Tikonata. Get ready for a full day of sightseeing on the next day: explore the striking landscape at Capachica Peninsula.

For photos, more things to do, traveler tips, and tourist information, refer to the Juliaca custom trip planner.

Traveling by car from Cusco to Juliaca takes 5.5 hours. Traveling from Cusco in May, expect little chillier with lows of -2°C in Juliaca. Finish your sightseeing early on the 25th (Thu) so you can travel to La Paz.

Things to do in Juliaca

Nature Parks Historic Sites
Highlights from your plan
Capachica Peninsula ©
Capachica Peninsula
Isla Tikonata ©
Isla Tikonata
Iglesia Matriz de Santa Catalina ©
Iglesia Matriz de Santa Catalina

2
nights
La Paz, Bolivia

Take a moment to catch your breath as you commence your holiday in La Paz.
Kick off your visit on the 26th (Fri): take in the spiritual surroundings of Iglesia de San Francisco, then make a trip to Mi Teleferico, and then explore the ancient world of Tiwanaku. Keep things going the next day: let your taste buds guide you at a local gastronomic tour, look for gifts at Unique, and then take in the dramatic natural features at Valle de la Luna.

To see ratings, other places to visit, traveler tips, and more tourist information, go to the La Paz trip itinerary maker.

Traveling by car from Juliaca to La Paz takes 5.5 hours. The time zone difference moving from Peru Time (PET) to Bolivia Time (BOT) is 1 hour. When traveling from Juliaca in May, plan for slightly colder days in La Paz, with highs around 17°C, while nights are about the same with lows around -2°C. Wrap up your sightseeing on the 27th (Sat) to allow time to travel to Oruro.

Things to do in La Paz

Tours Nature Parks
Highlights from your plan
Food Tours
Tiwanaku ©
Tiwanaku
Mi Teleferico ©
Mi Teleferico

2
nights
Oruro, Bolivia

Oruro ©
Located about halfway between La Paz and Sucre, the city of Oruro (also known as Uru Uru) sits at an elevation of 3,709 m (12,169 ft) above sea level.
On the 28th (Sun), learn more about the world around you at Archaeological Museum, make a trip to Plaza 10 de Febrero, and then pause for some serene contemplation at Catedral de Oruro. Get ready for a full day of sightseeing on the 29th (Mon): make a trip to Las Mina de San Jose and then contemplate in the serene atmosphere at Sanctuary of El Socavon.

To see reviews, maps, more things to do, and other tourist information, read our Oruro trip itinerary builder.

Traveling by combination of car and flight from La Paz to Oruro takes 2.5 hours. Alternatively, you can drive; or take a bus. Expect a daytime high around 20°C in May, and nighttime lows around -4°C. On the 29th (Mon), wrap the sightseeing up by early afternoon so you can drive to Uyuni.

Things to do in Oruro

Historic Sites Museums
Highlights from your plan
Catedral de Oruro ©
Catedral de Oruro

2
nights
Uyuni, Bolivia

Uyuni ©
Emptiness surrounds the desert outpost of Uyuni, the gateway to the world's largest salt flats.
Start off your visit on the 30th (Tue): step off the mainland to explore Isla Incahuasi, then explore the striking landscape at Salar de Uyuni, and then see the interesting displays at Museo de la Llama y la Sal. Get ready for a full day of sightseeing on the 31st (Wed): witness a stunning natural landmark at Geiser Sol de Manana, don't miss a visit to Plaza Arce, then see the interesting displays at Train Cemetery, and finally make a trip to Aguas Termales.

For traveler tips, photos, and tourist information, you can read our Uyuni travel planner.

Getting from Oruro to Uyuni by car takes about 5 hours. Other options: do a combination of bus, car, and flight; or take a train. While traveling from Oruro, expect cooler days and a bit warmer nights in Uyuni, ranging from highs of 3°C to lows of 3°C. Wrap up your sightseeing on the 31st (Wed) early enough to drive to Tupiza.

Things to do in Uyuni

Nature Parks Museums

Side Trip

Museo de la Llama y la Sal
Highlights from your plan
Salar de Uyuni ©
Salar de Uyuni
Isla Incahuasi ©
Isla Incahuasi
Train Cemetery ©
Train Cemetery

2
nights
Tupiza, Bolivia

Tupiza
The southwestern mining town of Tupiza, near the Argentine border, reminisces of the wild west, and is supposedly the place where Butch Cassidy and the Sundance Kid faced their demise after a long string of bank robberies.
To see ratings, traveler tips, more things to do, and other tourist information, read Tupiza itinerary maker.

You can drive from Uyuni to Tupiza in 3.5 hours. Another option is to take a train. On the 2nd (Fri), you'll travel to Province of Jujuy.

Things to do in Tupiza

Tours Outdoors Wildlife

2
nights
Province of Jujuy, Argentina

Province of Jujuy ©
San Salvador de Jujuy, commonly known as Jujuy and locally often referred to as San Salvador, is the capital city of Jujuy Province in northwest Argentina. Kick off your visit on the 3rd (Sat): make a trip to Algarrobo Historico, then hike along Paseo de los Colorados, and then delve into the distant past at Pucara de Tilcara. Get ready for a full day of sightseeing on the next day: take in the awesome beauty at The Hill of Seven Colors.

For maps, other places to visit, traveler tips, and other tourist information, use the Province of Jujuy sightseeing planner.

Drive from Tupiza to Province of Jujuy in 5.5 hours. Alternatively, you can do a combination of car and flight. Due to the time zone difference, you'll lose 1 hour traveling from Tupiza to Province of Jujuy. In June, plan for daily highs up to 22°C, and evening lows to 9°C. Finish your sightseeing early on the 4th (Sun) so you can travel to Termas de Rio Hondo.

Things to do in Province of Jujuy

Parks Trails Outdoors
Highlights from your plan
The Hill of Seven Colors ©
The Hill of Seven Colors
Pucara de Tilcara ©
Pucara de Tilcara
Paseo de los Colorados ©
Paseo de los Colorados

2
nights
Termas de Rio Hondo, Argentina

Termas de Rio Hondo ©
Proximity to natural hot springs ensure that Termas de Rio Hondo's tourism sector continues to prosper, providing employment for many residents and bringing in a considerable income for the entire area.
Start off your visit on the 5th (Mon): get outside with Circuito Termas de Rio Hondo, don't miss a visit to Represa Rio Hondo, and then examine the collection at Museo Del Automovil. Here are some ideas for day two: see the interesting displays at Museo Municipal Rincon de Atacama and then look for all kinds of wild species at Reserva Natural Tara Inti.

To see traveler tips, reviews, maps, and other tourist information, read our Termas de Rio Hondo travel planner.

You can drive from Province of Jujuy to Termas de Rio Hondo in 5.5 hours. Alternatively, you can do a combination of car and flight. June in Termas de Rio Hondo sees daily highs of 23°C and lows of 9°C at night. Finish your sightseeing early on the 6th (Tue) to allow enough time to travel to Rafaela.

Things to do in Termas de Rio Hondo

Outdoors Museums Wildlife
Highlights from your plan
Museo Del Automovil ©
Museo Del Automovil
Dique Frontal Río Hondo ©
Dique Frontal Río Hondo

3
nights
Rafaela, Argentina

Rafaela ©
Rafaela is a city in the province of Santa Fe, Argentina, about 96 km from the provincial capital. On the 7th (Wed), explore the world behind art at Museo Municipal De Bellas Artes Dr. Urbano Poggi, examine the collection at Asociacion de Ferromodelistas y Amigos del Ferrocarril de Rafaela, then get engrossed in the history at Museo Historico Municipal, and finally take an in-depth tour of Complejo Museografico Municipal.

For where to stay, photos, and other tourist information, use the Rafaela online itinerary creator.

Drive from Termas de Rio Hondo to Rafaela in 7.5 hours. In June, daytime highs in Rafaela are 21°C, while nighttime lows are 8°C. You will leave for home on the 9th (Fri).

Things to do in Rafaela

Museums
Highlights from your plan

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