41 days in South America Itinerary

41 days in South America Itinerary

Created using Inspirock South America vacation planner

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Route & dates

41 days in South America Itinerary

Start: Mexico City, Mexico
Fly:  10​h
1
Cartagena, Colombia
— 3 nights
Fly:  4​h
2
Medellin, Colombia
— 2 nights
Fly:  7​h 30​min
3
Cusco, Peru
— 4 nights
+2
bus + foot + train:  3​h 30​min
4
Machu Picchu, Peru
— 3 nights
train + taxi:  2​h
5
Maras, Peru
— 2 nights
Fly + Drive:  5​h
6
Uyuni, Bolivia
— 5 nights
taxi + Fly:  18​h
7
Punta Arenas, Chile
— 4 nights
bus:  8​h
8
Ushuaia, Argentina
— 2 nights
Fly:  2​h
9
El Calafate, Argentina
— 2 nights
bus:  3​h
10
El Chalten, Argentina
— 2 nights
+4
bus + taxi + Fly + taxi + bus:  8​h
11
Puerto Madryn, Argentina
— 2 nights
+2
bus + taxi + Fly:  9​h
12
San Carlos de Bariloche, Argentina
— 3 nights
Fly:  5​h 30​min
13
Buenos Aires, Argentina
— 3 nights
Fly:  7​h
End: Sao Paulo, Brazil

3
nights
Cartagena, Colombia

Cartagena ©
The site of the continent's first Spanish colony, Cartagena retains much of its colonial flavor thanks to a World Heritage-listed old town, encircled by old walls and protected by imposing fortresses.
You'll discover tucked-away gems like Plaza Santo Domingo and Aviario Nacional de Colombia. And it doesn't end there: contemplate the long history of Torre del Reloj, explore the historical opulence of Castillo de San Felipe de Barajas, take in the architecture and atmosphere at Sanctuary of Saint Peter Claver, and don't miss a visit to Centro de Convenciones Cartagena de Indias.

To plan Cartagena vacation without wasting time, ask Inspirock to design an itinerary.

Mexico City, Mexico to Cartagena is an approximately 10-hour flight. Due to the time zone difference, you'll lose 1 hour traveling from Mexico City to Cartagena. Traveling from Mexico City in September, you will find days in Cartagena are somewhat warmer (91°F), and nights are much warmer (78°F). Finish your sightseeing early on the 5th (Thu) so you can travel to Medellin.

Things to do in Cartagena

Historic Sites Wildlife Parks

Side Trip

Aviario Nacional de Colombia
Highlights from your plan
Walled City of Cartagena ©
Walled City of Cartagena
Plaza Santo Domingo ©
Plaza Santo Domingo
Torre del Reloj ©
Torre del Reloj

2
nights
Medellin, Colombia

Nestled between rising hills in a narrow valley, Medellin serves as an energetic melting pot of people from all socio-economic classes.
Eschew the tourist crowds and head to Museo de Antioquia and Planetario de Medellin. And it doesn't end there: make a trip to Plaza Botero, let the kids burn off some steam at Parque Lleras, whizz through the canopy at some of the top local zipline courses and adventure parks, and walk around Parque San Antonio.

For ratings, more things to do, reviews, and tourist information, you can read our Medellin tour app .

Traveling by flight from Cartagena to Medellin takes 4 hours. Alternatively, you can do a combination of bus and flight; or drive. In September, Medellin is little chillier than Cartagena - with highs of 82°F and lows of 64°F. Cap off your sightseeing on the 7th (Sat) early enough to travel to Cusco.

Things to do in Medellin

Tours Adventure Outdoors
Highlights from your plan
Walking tours
Museo de Antioquia ©
Museo de Antioquia
Plaza Botero ©
Plaza Botero

4
nights
Cusco, Peru

Cusco ©
Capital of the Inca Empire for three centuries, World Heritage-listed Cusco is now a major tourist destination, drawing nearly 2 million annual tourists with its well-preserved colonial architecture and proximity to Machu Picchu.
You'll discover tucked-away gems like Horseback Riding Tours and Cerro Colorado Vinicunca. Change things up with these side-trips from Cusco: Piquillacta (in Huarcapay) and San Pedro Apostol de Andahuaylillas (in Andahuaylillas). And it doesn't end there: indulge in some personalized pampering at some of the best spas, contemplate the waterfront views at Humantay Lake, steep yourself in history at Sacsayhuaman, and explore the ancient world of Tipon.

To find more things to do, reviews, traveler tips, and tourist information, refer to the Cusco online trip itinerary builder .

Traveling by flight from Medellin to Cusco takes 7.5 hours. Alternatively, you can drive; or take a bus. Expect slightly colder weather when traveling from Medellin in September: highs in Cusco hover around 71°F, while lows dip to 41°F. Finish your sightseeing early on the 11th (Wed) to allow enough time to travel to Machu Picchu.

Things to do in Cusco

Parks Historic Sites Nature

Side Trips

San Pedro Apostol de Andahuaylillas, Piquillacta
Highlights from your plan
exploor ©
exploor
Horseback Riding Tours
Sacsayhuaman ©
Sacsayhuaman

3
nights
Machu Picchu, Peru

Machu Picchu ©
A symbol of the Incan civilization, the abandoned city of Machu Picchu represents a must-see on a Peru vacation.
Discover out-of-the-way places like Los Jardines de Mandor and Banos Termales de Cocalmayo. Next up on the itinerary: delve into the distant past at Santuario Historico de Machu Picchu, examine the collection at Museo de Sitio Manuel Chavez Ballon, look for all kinds of wild species at Jardin Botanico en Machu Pichu, and take your sightseeing to a higher altitude at Phutuq K'usi.

For ratings, reviews, traveler tips, and tourist information, read Machu Picchu driving holiday planner.

You can do a combination of bus and train from Cusco to Machu Picchu in 3.5 hours. Other options are to take a train; or drive. Wrap up your sightseeing on the 14th (Sat) early enough to travel to Maras.

Things to do in Machu Picchu

Parks Historic Sites Nature

Side Trip

Banos Termales de Cocalmayo
Highlights from your plan
Santuario Historico de Machu Picchu ©
Los Jardines de Mandor ©
Los Jardines de Mandor
Winay Wayna ©
Winay Wayna

2
nights
Maras, Peru

Maras ©
Maras is a town in the Sacred Valley of the Incas, 40 kilometers north of Cuzco, in the Cuzco Region of Peru. Kick off your visit on the 15th (Sun): hike along Urubamba Weavers' Route, then see the interesting displays at Yucay Museo de Cultura Viva, then take in the dramatic natural features at Salinas de Maras, and finally steep yourself in history at Moray.

To find ratings, photos, more things to do, and more tourist information, refer to the Maras travel planner.

Traveling by combination of train and taxi from Machu Picchu to Maras takes 2 hours. Alternatively, you can drive. In September, daily temperatures in Maras can reach 71°F, while at night they dip to 41°F. Cap off your sightseeing on the 16th (Mon) early enough to travel to Uyuni.

Things to do in Maras

Parks Trails Outdoors

Side Trips

Yucay Museo de Cultura Viva, Urubamba Weavers' Route
Highlights from your plan
Salinas de Maras ©
Salinas de Maras
Moray ©
Moray
Urubamba Weavers' Route ©
Urubamba Weavers' Route

5
nights
Uyuni, Bolivia

Uyuni ©
Emptiness surrounds the desert outpost of Uyuni, the gateway to the world's largest salt flats.
You'll explore the less-touristy side of things at Isla Incahuasi and Train Cemetery. When in Uyuni, make a side trip to see Museo de la Llama y la Sal in Colchani, approximately 1h 20 min away. There's still lots to do: explore the striking landscape at Salar de Uyuni, don't miss a visit to San Cristobal de Lipez, get to know the fascinating history of Avenida Ferroviaria, and do sightseeing your way with Private Tours.

To find other places to visit, maps, traveler tips, and tourist information, you can read our Uyuni journey planner .

Getting from Maras to Uyuni by combination of flight and car takes about 5 hours. Other options: do a combination of flight, bus, and car; or drive. Traveling from Maras to Uyuni, you'll lose 1 hour due to the time zone difference. Traveling from Maras in September, expect nights in Uyuni to be little chillier, around 33°F, while days are cooler, around 35°F. Wrap up your sightseeing on the 21st (Sat) to allow time to travel to Punta Arenas.

Things to do in Uyuni

Nature Parks Outdoors

Side Trip

Museo de la Llama y la Sal
Highlights from your plan
Salar de Uyuni ©
Salar de Uyuni
Isla Incahuasi ©
Isla Incahuasi
Train Cemetery ©
Train Cemetery

4
nights
Punta Arenas, Chile

Punta Arenas ©
An erstwhile hub of the sheep wool industry, Punta Arenas has evolved into a gateway of sorts for hikers, cruise ship passengers, and adventure travelers heading out on the windswept lands of Chile's extreme southern reaches.
You'll discover tucked-away gems like Faro San Isidro and Antarctica21. There's much more to do: get outside with Strait of Magellan, ponder the world of politics at Palacio Montes Pello, experience rural life at El Galpon, and fly down the slopes at Club Andino Centro de Ski.

To see other places to visit, photos, maps, and more tourist information, refer to the Punta Arenas travel route planning app .

You can do a combination of taxi and flight from Uyuni to Punta Arenas in 18 hours. Other options are to drive; or do a combination of taxi and bus. Traveling from Uyuni in September, expect nights in Punta Arenas to be about the same, around 34°F, while days are somewhat warmer, around 47°F. Cap off your sightseeing on the 26th (Thu) early enough to catcht the bus to Ushuaia.

Things to do in Punta Arenas

Outdoors Parks Historic Sites
Highlights from your plan
Antarctica21 ©
Antarctica21
Faro San Isidro ©
Faro San Isidro
Reserva nacional Magallanes ©
Reserva nacional Magallanes

2
nights
Ushuaia, Argentina

Ushuaia ©
Often called the "End of the World" because of its position on the southernmost tip of South America, the expanding city of Ushuaia serves as both a busy commercial port and attractive tourist hub.
Start off your visit on the 27th (Fri): take an unforgettable tour with a helicopter tour, explore the activities along Lago Roca, and then head off the coast to Isla Bridges. Keep things going the next day: explore the striking landscape of Tierra del Fuego National Park and then make a trip to Galeria Tematica Historia Fueguina.

For reviews, traveler tips, more things to do, and tourist information, refer to the Ushuaia day trip tool .

Take a bus from Punta Arenas to Ushuaia in 8 hours. Alternatively, you can do a combination of ferry and car. The time zone changes from Chile Time (CLT) to Argentine Time (ART), which is usually a 1 hour difference. In September in Ushuaia, expect temperatures between 45°F during the day and 35°F at night. Finish your sightseeing early on the 28th (Sat) so you can travel to El Calafate.

Things to do in Ushuaia

Nature Parks Tours

Side Trip

Lago Roca
Highlights from your plan
Lago Roca ©
Lago Roca
Helicopter Tours
Galeria Tematica Historia Fueguina ©

2
nights
El Calafate, Argentina

El Calafate ©
El Calafate tourism thrives mostly thanks to the city's proximity to a World Heritage-listed national park, famed for containing over 40 large glaciers.
Start off your visit on the 29th (Sun): make a trip to Parque Nacional Los Glaciares. Get ready for a full day of sightseeing on the 30th (Mon): explore the striking landscape at Onelli Glacier, get a new perspective on nature at Museo Regional Municipal de El Calafate, and then get outside with Enjoy!.

To see other places to visit, reviews, maps, and more tourist information, read El Calafate trip tool .

Traveling by flight from Ushuaia to El Calafate takes 2 hours. Alternatively, you can do a combination of car and ferry; or take a bus. Expect a bit warmer evenings in El Calafate when traveling from Ushuaia in September, with lows around 44°F. Wrap up your sightseeing on the 30th (Mon) early enough to take a bus to El Chalten.

Things to do in El Calafate

Nature Parks Outdoors
Highlights from your plan
Parque Nacional Los Glaciares ©
Parque Nacional Los Glaciares
Onelli Glacier ©
Onelli Glacier

2
nights
El Chalten, Argentina

El Chalten ©
Nestled up against the hills of the Los Glaciares National Park, El Chalten serves as one of the nation's most bustling hubs for hikers and backpackers heading out into the wild landscape of southern Patagonia.
On the 1st (Tue), stroll through Fitz Roy. Here are some ideas for day two: look for gifts at Marcopolo Bookstore, explore the striking landscape at Amanecer en El Chalten, and then get great views at El Mirador De Los Condores.

For where to stay, more things to do, reviews, and more tourist information, read El Chalten attractions planning website .

Traveling by bus from El Calafate to El Chalten takes 3 hours. Alternatively, you can drive. Cap off your sightseeing on the 2nd (Wed) early enough to travel to Puerto Madryn.

Things to do in El Chalten

Nature Parks Trails
Highlights from your plan
Fitz Roy ©
Fitz Roy
El Mirador De Los Condores ©
El Mirador De Los Condores

2
nights
Puerto Madryn, Argentina

Puerto Madryn ©
Whales and penguins frolic in the waters of Puerto Madryn, one of Argentine Patagonia's most important port cities.
Kick off your visit on the 3rd (Thu): explore the activities along Peninsula Valdes and then see the interesting displays at Museo de Gemas. Here are some ideas for day two: take in the waterfront at Muelle Luis Piedra Buena and then kick back and relax at Costas de Patagonia.

For where to stay, ratings, more things to do, and tourist information, go to the Puerto Madryn trip planner .

Getting from El Chalten to Puerto Madryn by combination of bus and flight takes about 8 hours. Other options: drive; or take a bus. Wrap up your sightseeing by early afternoon on the 4th (Fri) to allow time for travel to San Carlos de Bariloche.

Things to do in Puerto Madryn

Parks Wildlife Nature
Highlights from your plan
Peninsula Valdes ©
Peninsula Valdes
Costas de Patagonia ©
Costas de Patagonia
Museo de Gemas ©
Museo de Gemas

3
nights
San Carlos de Bariloche, Argentina

San Carlos de Bariloche
Nestled against the foothills of the Andes, scenic San Carlos de Bariloche hugs the southern shore of Nahuel Huapi Lake and ranks among Argentina's top destinations for active outdoor vacations.
You'll explore the less-touristy side of things at Parque Nacional Nahuel Huapi and Parroquia San Eduardo. And it doesn't end there: test your problem-solving skills at popular escape rooms, tour the pleasant surroundings at Catedral Alta Patagonis, hike along Circuito Chico, and head outdoors with Refugio Neumeyer.

Start your trip to San Carlos de Bariloche by creating a personalized itinerary on Inspirock.

Traveling by combination of bus and flight from Puerto Madryn to San Carlos de Bariloche takes 9 hours. Alternatively, you can drive; or fly. October in San Carlos de Bariloche sees daily highs of 58°F and lows of 34°F at night. Finish up your sightseeing early on the 7th (Mon) so you can travel to Buenos Aires.

Things to do in San Carlos de Bariloche

Outdoors Parks Winter Sports
Highlights from your plan
Catedral Alta Patagonis
Catedral Alta Patagonis
Parque Nacional Nahuel Huapi ©
Parque Nacional Nahuel Huapi
Room Escape Games

3
nights
Buenos Aires, Argentina

Cultural capital of South America, Buenos Aires remains one of the largest cities on the continent, serving as a point of departure for exploring the rest of the country.
You'll discover tucked-away gems like Parque 3 de Febrero and Rosedal De Palermo. And it doesn't end there: take a pleasant ride with a tour on horseback, pause for some serene contemplation at Basilica del Santisimo Sacramento, see the interesting displays at Museo Del Bicentenario, and take a stroll around Usina del Arte.

For reviews, photos, and more tourist information, use the Buenos Aires day trip planning tool .

You can fly from San Carlos de Bariloche to Buenos Aires in 5.5 hours. Alternatively, you can drive; or take a bus. When traveling from San Carlos de Bariloche in October, plan for a bit warmer days in Buenos Aires, with highs around 69°F, while nights are much hotter with lows around 58°F. On the 11th (Fri), wrap the sightseeing up by early afternoon so you can travel back home.

Things to do in Buenos Aires

Parks Outdoors Tours
Highlights from your plan
Horseback Riding Tours
Parque 3 de Febrero ©
Parque 3 de Febrero
Basilica del Santisimo Sacramento ©
Basilica del Santisimo Sacramento

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