41 days in South America Itinerary

41 days in South America Itinerary

Created using Inspirock South America travel planner

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Route & dates

41 days in South America Itinerary

Start: Mexico City, Mexico
Fly:  10​h
1
Cartagena, Colombia
— 3 nights
Fly:  4​h
2
Medellin, Colombia
— 2 nights
Fly:  7​h 30​min
3
Cusco, Peru
— 4 nights
+2
bus + foot + train:  3​h 30​min
4
Machu Picchu, Peru
— 3 nights
train + taxi:  2​h
5
Maras, Peru
— 2 nights
Fly + Drive:  5​h
6
Uyuni, Bolivia
— 5 nights
taxi + Fly:  18​h
7
Punta Arenas, Chile
— 4 nights
bus:  8​h
8
Ushuaia, Argentina
— 2 nights
Fly:  2​h
9
El Calafate, Argentina
— 2 nights
bus:  3​h
10
El Chalten, Argentina
— 2 nights
+4
bus + taxi + Fly + taxi + bus:  8​h
11
Puerto Madryn, Argentina
— 2 nights
+2
bus + taxi + Fly:  9​h
12
San Carlos de Bariloche, Argentina
— 3 nights
Fly:  5​h 30​min
13
Buenos Aires, Argentina
— 3 nights
Fly:  6​h
End: Sao Paulo, Brazil

3
nights
Cartagena, Colombia

Cartagena ©
The site of the continent's first Spanish colony, Cartagena retains much of its colonial flavor thanks to a World Heritage-listed old town, encircled by old walls and protected by imposing fortresses.
Step off the beaten path and head to Plaza Santo Domingo and Convent of Santa Cruz de la Popa. Go for a jaunt from Cartagena to Isla Baru to see Aviario Nacional de Colombia about 50 minutes away. The adventure continues: make a trip to Torre del Reloj, contemplate in the serene atmosphere at Templo de Santo Domingo, step into the grandiose world of Castillo de San Felipe de Barajas, and take in the architecture and atmosphere at Sanctuary of Saint Peter Claver.

To find other places to visit, traveler tips, maps, and tourist information, refer to the Cartagena trip planning tool .

Mexico City, Mexico to Cartagena is an approximately 10-hour flight. The time zone changes from Central Standard Time (CST) to Colombia Time (COT), which is usually a 1 hour difference. While traveling from Mexico City, expect somewhat warmer days and much warmer nights in Cartagena, ranging from highs of 38°C to lows of 30°C. Wrap up your sightseeing on the 16th (Wed) early enough to travel to Medellin.

Things to do in Cartagena

Historic Sites Wildlife Parks

Side Trip

Aviario Nacional de Colombia
Highlights from your plan
Walled City of Cartagena ©
Walled City of Cartagena
Plaza Santo Domingo ©
Plaza Santo Domingo
Torre del Reloj ©
Torre del Reloj

2
nights
Medellin, Colombia

Nestled between rising hills in a narrow valley, Medellin serves as an energetic melting pot of people from all socio-economic classes.
Explore hidden gems such as Museo de Antioquia and Zipline. There's still lots to do: make a trip to Plaza Botero, look and learn at Planetario de Medellin, walk around Parque San Antonio, and admire nature's wide array of creatures at Parque Explora.

For other places to visit, ratings, maps, and more tourist information, refer to the Medellin day trip planning site .

You can fly from Cartagena to Medellin in 4 hours. Alternatively, you can do a combination of bus and flight; or drive. Traveling from Cartagena in October, things will get a bit cooler in Medellin: highs are around 32°C and lows about 20°C. Wrap up your sightseeing on the 18th (Fri) to allow time to travel to Cusco.

Things to do in Medellin

Tours Adventure Outdoors
Highlights from your plan
Walking tours
Plaza Botero ©
Plaza Botero
Museo de Antioquia ©
Museo de Antioquia

4
nights
Cusco, Peru

Cusco ©
Capital of the Inca Empire for three centuries, World Heritage-listed Cusco is now a major tourist destination, drawing nearly 2 million annual tourists with its well-preserved colonial architecture and proximity to Machu Picchu.
Step off the beaten path and head to Horseback Riding Tours and San Pedro Apostol de Andahuaylillas. When in Cusco, make a side trip to see Piquillacta in Huarcapay, approximately 48 minutes away. And it doesn't end there: take in the dramatic natural features at Cerro Colorado Vinicunca, explore the ancient world of Q'enqo, indulge in some personalized pampering at some of the best spas, and hike along exploor.

To find photos, ratings, and tourist information, refer to the Cusco trip app .

Getting from Medellin to Cusco by flight takes about 7.5 hours. Other options: drive; or take a bus. While traveling from Medellin, expect a bit cooler days and much colder nights in Cusco, ranging from highs of 24°C to lows of 7°C. Cap off your sightseeing on the 22nd (Tue) early enough to travel to Machu Picchu.

Things to do in Cusco

Parks Historic Sites Nature

Side Trips

Piquillacta, San Pedro Apostol de Andahuaylillas
Highlights from your plan
exploor ©
exploor
Horseback Riding Tours
Sacsayhuaman ©
Sacsayhuaman

3
nights
Machu Picchu, Peru

Machu Picchu ©
A symbol of the Incan civilization, the abandoned city of Machu Picchu represents a must-see on a Peru vacation.
Discover out-of-the-way places like Los Jardines de Mandor and Phutuq K'usi. There's much more to do: explore the ancient world of Santuario Historico de Machu Picchu, witness a stunning natural landmark at Banos Termales de Cocalmayo, examine the collection at Museo de Sitio Manuel Chavez Ballon, and identify plant and animal life at Jardin Botanico en Machu Pichu.

To find more things to do, traveler tips, where to stay, and other tourist information, you can read our Machu Picchu trip builder tool .

Getting from Cusco to Machu Picchu by combination of bus and train takes about 3.5 hours. Other options: take a train; or drive. Wrap up your sightseeing on the 25th (Fri) to allow time to travel to Maras.

Things to do in Machu Picchu

Parks Historic Sites Nature

Side Trip

Banos Termales de Cocalmayo
Highlights from your plan
Santuario Historico de Machu Picchu ©
Los Jardines de Mandor ©
Los Jardines de Mandor
Winay Wayna ©
Winay Wayna

2
nights
Maras, Peru

Maras ©
Maras is a town in the Sacred Valley of the Incas, 40 kilometers north of Cuzco, in the Cuzco Region of Peru. Kick off your visit on the 26th (Sat): stroll through Urubamba Weavers' Route, then see the interesting displays at Yucay Museo de Cultura Viva, then stroll through Salinas de Maras, and finally steep yourself in history at Moray.

To find maps, photos, traveler tips, and other tourist information, read our Maras travel itinerary planner .

You can do a combination of train and taxi from Machu Picchu to Maras in 2 hours. Alternatively, you can drive. In October, daytime highs in Maras are 24°C, while nighttime lows are 7°C. Finish your sightseeing early on the 27th (Sun) to allow enough time to travel to Uyuni.

Things to do in Maras

Parks Outdoors Trails

Side Trips

Yucay Museo de Cultura Viva, Urubamba Weavers' Route
Highlights from your plan
Salinas de Maras ©
Salinas de Maras
Moray ©
Moray
Urubamba Weavers' Route ©
Urubamba Weavers' Route

5
nights
Uyuni, Bolivia

Uyuni ©
Emptiness surrounds the desert outpost of Uyuni, the gateway to the world's largest salt flats.
You'll discover tucked-away gems like Isla Incahuasi and Tunupa Volcano. Take a break from Uyuni with a short trip to Museo de la Llama y la Sal in Colchani, about 1h 20 min away. The adventure continues: see the interesting displays at Train Cemetery, appreciate the extensive heritage of Avenida Ferroviaria, get a new perspective on nature at Museo Arquecologia y Antropologico de los Andes Meridionales, and pause for some serene contemplation at Iglesia San Cristobal Lipez.

To find other places to visit, where to stay, photos, and tourist information, use the Uyuni holiday planner.

Do a combination of flight and car from Maras to Uyuni in 5 hours. Alternatively, you can do a combination of flight, bus, and car; or drive. Due to the time zone difference, you'll lose 1 hour traveling from Maras to Uyuni. Traveling from Maras in October, expect nights in Uyuni to be about the same, around 7°C, while days are colder, around 8°C. Cap off your sightseeing on the 1st (Fri) early enough to travel to Punta Arenas.

Things to do in Uyuni

Nature Parks Outdoors

Side Trip

Museo de la Llama y la Sal
Highlights from your plan
Salar de Uyuni ©
Salar de Uyuni
Isla Incahuasi ©
Isla Incahuasi
Train Cemetery ©
Train Cemetery

4
nights
Punta Arenas, Chile

Punta Arenas ©
An erstwhile hub of the sheep wool industry, Punta Arenas has evolved into a gateway of sorts for hikers, cruise ship passengers, and adventure travelers heading out on the windswept lands of Chile's extreme southern reaches.
Discover out-of-the-way places like Faro San Isidro and Strait of Magellan. The adventure continues: head outdoors with Antarctica21, explore the striking landscape at Cabo Froward, make a trip to Plaza de Armas, and look for all kinds of wild species at Reserva nacional Magallanes.

For ratings, more things to do, traveler tips, and tourist information, refer to the Punta Arenas trip planner .

Traveling by combination of taxi and flight from Uyuni to Punta Arenas takes 18 hours. Alternatively, you can drive; or do a combination of taxi and bus. Plan for little chillier nights when traveling from Uyuni in November since evenings lows in Punta Arenas dip to 5°C. Wrap up your sightseeing on the 6th (Wed) early enough to take a bus to Ushuaia.

Things to do in Punta Arenas

Outdoors Parks Historic Sites
Highlights from your plan
Antarctica21 ©
Antarctica21
Reserva nacional Magallanes ©
Reserva nacional Magallanes
Cabo Froward ©
Cabo Froward

2
nights
Ushuaia, Argentina

Ushuaia ©
Often called the "End of the World" because of its position on the southernmost tip of South America, the expanding city of Ushuaia serves as both a busy commercial port and attractive tourist hub.
On the 7th (Thu), take an unforgettable tour with a helicopter tour, contemplate the waterfront views at Lago Roca, and then head off the coast to Isla Bridges. Get ready for a full day of sightseeing on the 8th (Fri): explore the striking landscape of Tierra del Fuego National Park and then don't miss a visit to Galeria Tematica Historia Fueguina.

To see traveler tips, more things to do, other places to visit, and more tourist information, go to the Ushuaia trip itinerary tool .

You can take a bus from Punta Arenas to Ushuaia in 8 hours. Another option is to do a combination of ferry and car. The time zone difference when traveling from Punta Arenas to Ushuaia is 1 hour. In November, daily temperatures in Ushuaia can reach 11°C, while at night they dip to 3°C. Finish up your sightseeing early on the 8th (Fri) so you can travel to El Calafate.

Things to do in Ushuaia

Nature Parks Tours

Side Trip

Lago Roca
Highlights from your plan
Lago Roca ©
Lago Roca
Helicopter Tours
Galeria Tematica Historia Fueguina ©

2
nights
El Calafate, Argentina

El Calafate ©
El Calafate tourism thrives mostly thanks to the city's proximity to a World Heritage-listed national park, famed for containing over 40 large glaciers.
Start off your visit on the 9th (Sat): make a trip to Parque Nacional Los Glaciares. Get ready for a full day of sightseeing on the 10th (Sun): take in the dramatic natural features at Onelli Glacier, then get a new perspective on nature at Museo Regional Municipal de El Calafate, and then head outdoors with Enjoy!.

To see traveler tips, other places to visit, reviews, and more tourist information, use the El Calafate road trip site .

You can fly from Ushuaia to El Calafate in 2 hours. Alternatively, you can do a combination of car and ferry; or take a bus. Traveling from Ushuaia in November, expect a bit warmer with lows of 13°C in El Calafate. Wrap up your sightseeing on the 10th (Sun) to allow time to take a bus to El Chalten.

Things to do in El Calafate

Nature Parks Outdoors
Highlights from your plan
Parque Nacional Los Glaciares ©
Parque Nacional Los Glaciares
Onelli Glacier ©
Onelli Glacier

2
nights
El Chalten, Argentina

El Chalten ©
Nestled up against the hills of the Los Glaciares National Park, El Chalten serves as one of the nation's most bustling hubs for hikers and backpackers heading out into the wild landscape of southern Patagonia.
On the 11th (Mon), trek along Fitz Roy. Get ready for a full day of sightseeing on the next day: stop by Marcopolo Bookstore, take in the awesome beauty at Amanecer en El Chalten, and then get great views at El Mirador De Los Condores.

To see traveler tips, where to stay, and tourist information, go to the El Chalten trip planning site .

You can take a bus from El Calafate to El Chalten in 3 hours. Another option is to drive. Wrap up your sightseeing on the 12th (Tue) to allow time to travel to Puerto Madryn.

Things to do in El Chalten

Nature Parks Outdoors
Highlights from your plan
Fitz Roy ©
Fitz Roy
El Mirador De Los Condores ©
El Mirador De Los Condores

2
nights
Puerto Madryn, Argentina

Puerto Madryn ©
Whales and penguins frolic in the waters of Puerto Madryn, one of Argentine Patagonia's most important port cities.
On the 13th (Wed), look for all kinds of wild species at Peninsula Valdes and then see the interesting displays at Museo de Gemas. Get ready for a full day of sightseeing on the next day: take a leisurely stroll along Muelle Luis Piedra Buena and then kick back and relax at Costas de Patagonia.

To find other places to visit, maps, traveler tips, and tourist information, read Puerto Madryn tour builder app .

Traveling by combination of bus and flight from El Chalten to Puerto Madryn takes 8 hours. Alternatively, you can drive; or take a bus. Wrap up your sightseeing by early afternoon on the 14th (Thu) to allow enough time to travel to San Carlos de Bariloche.

Things to do in Puerto Madryn

Parks Wildlife Nature
Highlights from your plan
Peninsula Valdes ©
Peninsula Valdes
Costas de Patagonia ©
Costas de Patagonia
Museo de Gemas ©
Museo de Gemas

3
nights
San Carlos de Bariloche, Argentina

San Carlos de Bariloche
Nestled against the foothills of the Andes, scenic San Carlos de Bariloche hugs the southern shore of Nahuel Huapi Lake and ranks among Argentina's top destinations for active outdoor vacations.
Explore hidden gems such as Parque Nacional Nahuel Huapi and Chocolates Rapanui. And it doesn't end there: test your team's savvy at popular escape rooms, get outside with Refugio Neumeyer, hunt for treasures at Feria Artesanal Municipal, and take in the spiritual surroundings of Parroquia San Eduardo.

To see reviews, where to stay, ratings, and tourist information, use the San Carlos de Bariloche journey planner.

Getting from Puerto Madryn to San Carlos de Bariloche by combination of bus and flight takes about 9 hours. Other options: drive; or fly. Expect a daytime high around 21°C in November, and nighttime lows around 3°C. Cap off your sightseeing on the 17th (Sun) early enough to travel to Buenos Aires.

Things to do in San Carlos de Bariloche

Outdoors Parks Winter Sports
Highlights from your plan
Catedral Alta Patagonis
Catedral Alta Patagonis
Parque Nacional Nahuel Huapi ©
Parque Nacional Nahuel Huapi
Parroquia San Eduardo ©
Parroquia San Eduardo

3
nights
Buenos Aires, Argentina

Cultural capital of South America, Buenos Aires remains one of the largest cities on the continent, serving as a point of departure for exploring the rest of the country.
Step off the beaten path and head to Parque 3 de Febrero and Horseback Riding Tours. There's still lots to do: take in the architecture and atmosphere at Basilica del Santisimo Sacramento, take a stroll through Puerto Madero, see the interesting displays at Museo Del Bicentenario, and admire the striking features of Centro Cultural Kirchner.

For traveler tips, ratings, more things to do, and tourist information, read our Buenos Aires journey site .

Traveling by flight from San Carlos de Bariloche to Buenos Aires takes 5.5 hours. Alternatively, you can drive; or take a bus. Traveling from San Carlos de Bariloche in November, expect nights in Buenos Aires to be much hotter, around 19°C, while days are somewhat warmer, around 28°C. On the 21st (Thu), wrap the sightseeing up by early afternoon so you can travel back home.

Things to do in Buenos Aires

Parks Outdoors Tours
Highlights from your plan
Horseback Riding Tours
Parque 3 de Febrero ©
Parque 3 de Febrero
Basilica del Santisimo Sacramento ©
Basilica del Santisimo Sacramento

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