31 days in South America & Santiago de Cuba Itinerary

31 days in South America & Santiago de Cuba Itinerary

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Route & dates

31 days in South America & Santiago de Cuba Itinerary

Start: San Francisco, United States
+3
Fly + Shuttle + Ferry + Bus:  18​h 30​min
1
Puerto Ayora, Ecuador
— 1 night
+3
Bus + Ferry + Shuttle + Fly:  8​h
2
Quito, Ecuador
— 1 day
Fly:  5​h 15​min
3
Cusco, Peru
— 4 nights
Fly:  14​h
4
San Carlos de Bariloche, Argentina
— 3 nights
Fly:  3​h 45​min
5
El Calafate, Argentina
— 2 nights
Fly:  2​h
6
Ushuaia, Argentina
— 3 nights
Fly:  7​h 45​min
7
Florianopolis, Brazil
— 3 nights
Fly:  5​h 30​min
8
Porto Seguro, Brazil
— 3 nights
Fly:  3​h 15​min
9
Brasilia, Brazil
— 1 night
Fly:  12​h
10
Cartagena, Colombia
— 2 nights
+2
Fly + Taxi + Train:  13​h 45​min
11
Santiago de Cuba, Cuba
— 2 nights
Fly:  17​h
End: San Francisco, United States

1
night
Puerto Ayora, Ecuador

Puerto Ayora ©
The largest settlement in the Galapagos, Puerto Ayora offers visitors to the islands an array of facilities and things to do.
On the 5th (Sun), explore the striking landscape at Las Grietas and then make a trip to Santa Cruz Fish Market. On the 6th (Mon), you'll have a packed day of sightseeing: identify plant and animal life at Reserva El Chato, admire the masterpieces at Maprae, then view the masterpieces at Galeria Exotico Ecuador, and finally kick back and relax at Galapagos Beach at Tortuga Bay.

To find where to stay, reviews, photos, and more tourist information, go to the Puerto Ayora trip itinerary builder site .

San Francisco, USA to Puerto Ayora is an approximately 18.5-hour combination of flight and ferry. The time zone difference moving from Pacific Standard Time (PST) to Ecuador Time (ECT) is 3 hours. Traveling from San Francisco in September, plan for a bit warmer nights in Puerto Ayora, with lows around 69°F. Wrap up your sightseeing on the 6th (Mon) to allow time to travel to Quito.

Things to do in Puerto Ayora

Parks Outdoors Nature

Side Trip

Santa Cruz
Highlights from your plan
El Chato - Giant Tortoise Reserve ©
El Chato - Giant Tortoise Reserve
Galapagos Beach at Tortuga Bay ©
Galapagos Beach at Tortuga Bay
Galeria Exotico Ecuador ©
Galeria Exotico Ecuador

1
day
Quito, Ecuador

Quito ©
High in the Andean foothills, Quito remains one of the world's most photogenic capital cities, featuring two dramatic mountain ranges as its backdrop.
Kick off your visit on the 7th (Tue): take an in-depth tour of Museo Templo del Sol Pintor Ortega Maila, pause for some photo ops at La Virgen del Panecillo, then take in the spiritual surroundings of Fundacion Iglesia de la Compania, and finally get to know the fascinating history of Quito Old Town.

For traveler tips, reviews, photos, and tourist information, read our Quito route planner .

You can do a combination of ferry and flight from Puerto Ayora to Quito in 8 hours. Traveling from Puerto Ayora in September, expect Quito to be little chillier, temps between 73°F and 56°F. Finish up your sightseeing early on the 7th (Tue) so you can travel to Cusco.

Things to do in Quito

Historic Sites Museums
Highlights from your plan
Quito Old Town ©
Quito Old Town
La Virgen del Panecillo ©
La Virgen del Panecillo

4
nights
Cusco, Peru

Cusco ©
Capital of the Inca Empire for three centuries, World Heritage-listed Cusco is now a major tourist destination, drawing nearly 2 million annual tourists with its well-preserved colonial architecture and proximity to Machu Picchu.
Get outdoors at Horseback Riding Tours and Santuario Animal de Cochahuasi. Do some cultural sightseeing at Tipon and Q'enqo. Explore Cusco's surroundings by going to Pisac (in Pisac) and Moray (in Maras). Next up on the itinerary: delve into the distant past at Sacred Valley of the Incas, take a stroll through San Blas, pause for some serene contemplation at Iglesia San Pedro, and admire the landmark architecture of The Company of Jesus Church.

To see maps, more things to do, other places to visit, and tourist information, use the Cusco trip planner.

Fly from Quito to Cusco in 5.5 hours. Alternatively, you can drive; or take a bus. Expect slightly colder evenings in Cusco when traveling from Quito in September, with lows around 41°F. Finish up your sightseeing early on the 11th (Sat) so you can travel to San Carlos de Bariloche.

Things to do in Cusco

Historic Sites Outdoors Tours

Side Trips

Pisac, Sacred Valley of the Incas, Moray
Highlights from your plan
Moray ©
Moray
Sacred Valley of the Incas ©
Sacred Valley of the Incas
Tipon ©
Tipon

3
nights
San Carlos de Bariloche, Argentina

San Carlos de Bariloche ©
Nestled against the foothills of the Andes, scenic San Carlos de Bariloche hugs the southern shore of Nahuel Huapi Lake and ranks among Argentina's top destinations for active outdoor vacations.
Discover out-of-the-way places like Puerto Blest y Cascada de los Cantaro and Cerro Tronador. Visiting Piedras Blancas and Isla Victoria will get you outdoors. There's lots more to do: contemplate in the serene atmosphere at Parroquia San Eduardo, explore the wealth of natural beauty at Parque Nacional Nahuel Huapi, surround yourself with nature on a nature and wildlife tour, and get some fabulous bargains at Chocolate Patagonico.

For ratings, reviews, and more tourist information, read our San Carlos de Bariloche trip planner .

Fly from Cusco to San Carlos de Bariloche in 14 hours. Alternatively, you can do a combination of flight and bus; or drive. You'll lose 2 hours traveling from Cusco to San Carlos de Bariloche due to the time zone difference. Prepare for slightly colder weather when traveling from Cusco in September: high temperatures in San Carlos de Bariloche hover around 52°F and lows are around 31°F. Cap off your sightseeing on the 15th (Wed) early enough to travel to El Calafate.

Things to do in San Carlos de Bariloche

Parks Nature Outdoors
Highlights from your plan
Puerto Blest y Cascada de los Cantaro ©
Parroquia San Eduardo ©
Parroquia San Eduardo
Nature & Wildlife Tours

2
nights
El Calafate, Argentina

El Calafate
El Calafate tourism thrives mostly thanks to the city's proximity to a World Heritage-listed national park, famed for containing over 40 large glaciers.
Kick off your visit on the 16th (Thu): shake up your sightseeing with a climbing tour and then contemplate the waterfront views at Lago Argentino. On the 17th (Fri), you'll have a packed day of sightseeing: get a new perspective on nature at Museo Regional Municipal de El Calafate and then explore the striking landscape at Upsala Glacier.

To find traveler tips, ratings, photos, and tourist information, you can read our El Calafate trip itinerary builder website .

Fly from San Carlos de Bariloche to El Calafate in 4 hours. Alternatively, you can take a bus; or drive. When traveling from San Carlos de Bariloche in September, plan for little chillier days and a bit warmer nights in El Calafate: temperatures range from 45°F by day to 44°F at night. Wrap up your sightseeing on the 17th (Fri) early enough to travel to Ushuaia.

Things to do in El Calafate

Nature Parks Outdoors
Highlights from your plan
Lago Argentino
Lago Argentino
Climbing Tours
Upsala Glacier ©
Upsala Glacier

3
nights
Ushuaia, Argentina

Ushuaia ©
Often called the "End of the World" because of its position on the southernmost tip of South America, the expanding city of Ushuaia serves as both a busy commercial port and attractive tourist hub.
Take a break from the city and head to Cerro Castor (Castor Mount) and Bahia Lapataia. Explore hidden gems such as Lago Roca and Les Éclaireurs Lighthouse. And it doesn't end there: contemplate the waterfront views at Laguna Esmeralda, stroll through Ushuaia Bay, and trek along Glacier Martial.

To see maps, other places to visit, more things to do, and tourist information, you can read our Ushuaia tour app .

You can fly from El Calafate to Ushuaia in 2 hours. Alternatively, you can do a combination of car and ferry; or take a bus. Expect slightly colder evenings in Ushuaia when traveling from El Calafate in September, with lows around 35°F. Finish your sightseeing early on the 20th (Mon) so you can travel to Florianopolis.

Things to do in Ushuaia

Parks Nature Outdoors

Side Trip

Lago Roca
Highlights from your plan
Cerro Castor (Castor Mount) ©
Cerro Castor (Castor Mount)
Ushuaia Bay ©
Ushuaia Bay
Lago Roca ©
Lago Roca

3
nights
Florianopolis, Brazil

Florianopolis ©
Divided between island and mainland, the distinctive city of Florianopolis charms visitors on first arrival with its impressive skyline.
Take a break from the city and head to Lagoinha do Leste and Praia do Rosa. We've included these beaches for you: Praia do Santinho and Barra da Lagoa Beach. Take a break from Florianopolis with a short trip to Bombinhas Beach in Bombinhas, about 1h 30 min away. There's more to do: appreciate the extensive heritage of Ribeirao da Ilha and tour the pleasant surroundings at Praia Mole.

To find maps, more things to do, other places to visit, and other tourist information, read Florianopolis trip planning site .

Traveling by flight from Ushuaia to Florianopolis takes 8 hours. Alternatively, you can do a combination of car and ferry; or take a bus. In September, Florianopolis is much warmer than Ushuaia - with highs of 72°F and lows of 60°F. Cap off your sightseeing on the 24th (Fri) early enough to travel to Porto Seguro.

Things to do in Florianopolis

Outdoors Beaches Parks

Side Trips

Bombinhas Beach, Praia do Rosa
Highlights from your plan
Lagoinha do Leste ©
Lagoinha do Leste
Praia do Santinho ©
Praia do Santinho
Ribeirao da Ilha ©
Ribeirao da Ilha

3
nights
Porto Seguro, Brazil

Porto Seguro ©
In a sense, Porto Seguro is where Brazil as a country began, marking the spot where Portuguese explorers first arrived in the 16th century.
Get outdoors at Muta Beach and Coroa Vermelha Beach. Visit Taperapua Beach and Pitinga Beach for some beach relaxation. The adventure continues: don't miss a visit to Largo da Ajuda, stop by Emporio Da Pimenta, take an in-depth tour of Ilha dos Aquarios, and look for all kinds of wild species at Recife de Fora.

Start your trip to Porto Seguro by creating a personalized itinerary on Inspirock.

Getting from Florianopolis to Porto Seguro by flight takes about 5.5 hours. Other options: drive; or take a bus. Prepare for a bit warmer weather when traveling from Florianopolis in September: high temperatures in Porto Seguro hover around 79°F and lows are around 67°F. Finish your sightseeing early on the 27th (Mon) so you can travel to Brasilia.

Things to do in Porto Seguro

Parks Outdoors Beaches

Side Trip

Coroa Vermelha Beach
Highlights from your plan
Muta Beach ©
Muta Beach
Capela de Nossa Senhora da Ajuda ©
Capela de Nossa Senhora da Ajuda
Coroa Vermelha Beach ©
Coroa Vermelha Beach

1
night
Brasilia, Brazil

Brasilia ©
Although it lacks the cultural flair of Rio de Janeiro and the massive urban sprawl of Sao Paulo, Brasilia holds a fascinating place in the tapestry of Brazil.
On the 28th (Tue), take in the architecture and atmosphere at Igrejinha N.S. De Fatima church, then stroll around Parque da Cidade Sarah Kubitschek, then snap pictures at JK Bridge, and finally admire the striking features of Templo da Boa Vontade.

For where to stay, traveler tips, reviews, and tourist information, read our Brasilia road trip planning site .

You can fly from Porto Seguro to Brasilia in 3.5 hours. Other options are to drive; or take a bus. When traveling from Porto Seguro in September, plan for a bit warmer days and a bit cooler nights in Brasilia: temperatures range from 86°F by day to 61°F at night. Finish your sightseeing early on the 28th (Tue) so you can travel to Cartagena.

Things to do in Brasilia

Parks Historic Sites
Highlights from your plan
Igrejinha N.S. De Fatima church ©
Igrejinha N.S. De Fatima church
Templo da Boa Vontade ©
Templo da Boa Vontade
Juscelino Kubitschek Bridge ©
Juscelino Kubitschek Bridge

2
nights
Cartagena, Colombia

Cartagena ©
The site of the continent's first Spanish colony, Cartagena retains much of its colonial flavor thanks to a World Heritage-listed old town, encircled by old walls and protected by imposing fortresses.
Your cultural itinerary includes sights like Scuba & Snorkeling and Plaza Santo Domingo. Discover out-of-the-way places like Aviario Nacional de Colombia and Convent of Santa Cruz de la Popa. Next up on the itinerary: steep yourself in history at Torre del Reloj, take in the architecture and atmosphere at Sanctuary of Saint Peter Claver, don't miss a visit to Plaza Bolivar, and take in the local highlights with Walking tours.

To find photos, traveler tips, other places to visit, and other tourist information, read Cartagena tour itinerary site .

Fly from Brasilia to Cartagena in 12 hours. Alternatively, you can do a combination of flight and bus; or drive. You'll gain 2 hours traveling from Brasilia to Cartagena due to the time zone difference. Traveling from Brasilia in September, you can expect nighttime temperatures to be a bit warmer in Cartagena, with lows of 78°F. Finish up your sightseeing early on the 1st (Fri) so you can travel to Santiago de Cuba.

Things to do in Cartagena

Tours Wildlife Outdoors

Side Trip

Aviario Nacional de Colombia
Highlights from your plan
Convent of Santa Cruz de la Popa ©
Convent of Santa Cruz de la Popa
Scuba & Snorkeling
Torre del Reloj ©
Torre del Reloj

2
nights
Santiago de Cuba, Cuba

Santiago de Cuba ©
Santiago de Cuba has taken almost as much influence from Haiti and the Dominican Republic as it has from Havana, distilling a concoction of cultures to create a city with a distinct identity.
Start off your visit on the 2nd (Sat): explore the different monuments and memorials at Cementerio Santa Ifigenia, take in the architecture and atmosphere at Iglesia Sagrada Familia, then explore the historical opulence of Castillo de San Pedro de la Roca, and finally visit a coastal fixture at Faro del Morro. Keep things going the next day: get engrossed in the history at Memorial Vilma Espin Guillois, contemplate the long history of Scalinata di Padre Pico, then stroll around Cespedes Park, and finally contemplate in the serene atmosphere at Cathedral of Our Lady of the Assumption.

To find other places to visit, ratings, and other tourist information, refer to the Santiago de Cuba travel route planning website .

Use the Route module to find suitable travel options from Cartagena to Santiago de Cuba. In October, daytime highs in Santiago de Cuba are 87°F, while nighttime lows are 74°F. Cap off your sightseeing on the 4th (Mon) early enough to travel back home.

Things to do in Santiago de Cuba

Historic Sites Parks Museums
Highlights from your plan
Castillo de San Pedro de la Roca ©
Cementerio Santa Ifigenia ©
Cementerio Santa Ifigenia

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