29 days in South America, Central America & Mexico Itinerary

29 days in South America, Central America & Mexico Itinerary

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Route & dates

29 days in South America, Central America & Mexico Itinerary

Start: Melbourne, Australia
Fly + Drive:  35​h
1
Machu Picchu, Peru
— 3 nights
Drive + Fly:  20​h 15​min
2
Medellin, Colombia
— 4 nights
Fly:  4​h
3
Cartagena, Colombia
— 2 nights
Fly:  5​h
4
Panama City, Panama
— 2 nights
Drive:  29​h
5
Antigua, Guatemala
— 3 nights
shuttle + Fly:  7​h 30​min
6
Cozumel, Mexico
— 4 nights
Drive:  2​h 30​min
7
Tulum, Mexico
— 5 nights
+2
bus + foot + Fly:  26​h
End: Melbourne, Australia

3
nights
Machu Picchu, Peru

Machu Picchu ©
A symbol of the Incan civilization, the abandoned city of Machu Picchu represents a must-see on a Peru vacation.
Start off your visit on the 11th (Sat): examine the collection at Museo de Sitio Manuel Chavez Ballon, stop by Arte Joyeria Rumiwasi, and then pause for some serene contemplation at Iglesia Virgen Del Carmen. On your second day here, contemplate the long history of Santuario Historico de Machu Picchu and then admire nature's wide array of creatures at Mariposario de Machupicchu.

Plan my day in Machu Picchu using traveler tips and tourist information provided by Inspirock.

Melbourne, Australia to Machu Picchu is an approximately 35-hour combination of flight and car. The time zone changes from Australian Eastern Standard Time (Victoria) to Peru Time, which is usually a -15 hour difference. Wrap up your sightseeing on the 13th (Mon) early enough to travel to Medellin.

Things to do in Machu Picchu

Historic Sites Shopping Zoos & Aquariums
Highlights from your plan
Santuario Historico de Machu Picchu ©
Mariposario de Machupicchu ©
Mariposario de Machupicchu
Iglesia Virgen Del Carmen ©
Iglesia Virgen Del Carmen

4
nights
Medellin, Colombia

Nestled between rising hills in a narrow valley, Medellin serves as an energetic melting pot of people from all socio-economic classes.
Step off the beaten path and head to Walking tours and Plaza Botero. You'll find plenty of places to visit near Medellin: Guatape (Iglesia de Nuestra Senora del Carmen & ALTITUDE). There's lots more to do: contemplate the waterfront views at Laguna de Guatape, make a trip to Escaleras Electricas De La Comuna 13, enjoy some diversion at Parque Lleras, and admire nature's wide array of creatures at Parque Explora.

To see more things to do, other places to visit, reviews, and other tourist information, read Medellin trip itinerary planner.

Do a combination of car and flight from Machu Picchu to Medellin in 20.5 hours. Alternatively, you can drive; or do a combination of car and bus. In April, daily temperatures in Medellin can reach 32°C, while at night they dip to 20°C. Finish your sightseeing early on the 17th (Fri) to allow enough time to travel to Cartagena.

Things to do in Medellin

Parks Outdoors Tours

Side Trips

Guatape, Parroquia la Nina Maria
Highlights from your plan
Walking tours
Laguna de Guatape ©
Laguna de Guatape
Parque Explora ©
Parque Explora

2
nights
Cartagena, Colombia

Cartagena ©
The site of the continent's first Spanish colony, Cartagena retains much of its colonial flavor thanks to a World Heritage-listed old town, encircled by old walls and protected by imposing fortresses.
You'll discover tucked-away gems like Plaza Santo Domingo and Plaza Bolivar. Take a break from Cartagena with a short trip to Aviario Nacional de Colombia in Isla Baru, about 50 minutes away. The adventure continues: don't miss a visit to Torre del Reloj, take in the architecture and atmosphere at Sanctuary of Saint Peter Claver, contemplate in the serene atmosphere at Convent of Santa Cruz de la Popa, and contemplate the long history of Walled City of Cartagena.

To find where to stay, ratings, more things to do, and other tourist information, you can read our Cartagena trip planning website .

You can fly from Medellin to Cartagena in 4 hours. Other options are to do a combination of flight and bus; or drive. In April, Cartagena is somewhat warmer than Medellin - with highs of 38°C and lows of 30°C. Wrap up your sightseeing on the 20th (Mon) to allow time to travel to Panama City.

Things to do in Cartagena

Historic Sites Neighborhoods Wildlife

Side Trip

Aviario Nacional de Colombia
Highlights from your plan
Bairro Getsemani ©
Bairro Getsemani
Plaza Santo Domingo ©
Plaza Santo Domingo
Torre del Reloj ©
Torre del Reloj

2
nights
Panama City, Panama

Arguably the most modern of Central American cities, Panama City boasts a shimmering skyline of glass skyscrapers.
Kick off your visit on the 21st (Tue): look for all kinds of wild species at Wildlife Areas, take in the architecture and atmosphere at El Arco Chato, and then test your problem-solving skills at popular escape rooms. On the 22nd (Wed), you'll have a packed day of sightseeing: don't miss a visit to Panama Canal, then take in the architecture and atmosphere at Iglesia de San Francisco de Asis, then don't miss a visit to Plaza Bolivar, and finally take in the architecture and atmosphere at Iglesia de la Merced.

To find photos, more things to do, where to stay, and tourist information, read Panama City online attractions planner .

You can fly from Cartagena to Panama City in 5 hours. Other options are to do a combination of bus and flight; or do a combination of flight and taxi. In April in Panama City, expect temperatures between 38°C during the day and 30°C at night. Wrap up your sightseeing on the 22nd (Wed) early enough to drive to Antigua.

Things to do in Panama City

Outdoors Wildlife Tours
Highlights from your plan
Nature & Wildlife Tours
Panama Canal ©
Panama Canal
Iglesia de la Merced ©
Iglesia de la Merced

3
nights
Antigua, Guatemala

Antigua ©
The former capital of Guatemala and a World Heritage Site, Antigua retains its colonial charm and remains one of the most visited destinations in the country.
Discover out-of-the-way places like Arco de Santa Catalina and Cerro de la Cruz. Next up on the itinerary: take an in-depth tour of Casa Santo Domingo Museums, examine the collection at La Azotea, don't miss a visit to San Jose El Viejo, and relax in the rural setting at Caoba Farms.

Plan my day in Antigua using traveler tips and tourist information provided by Inspirock.

Traveling by car from Panama City to Antigua takes 29 hours. Alternatively, you can take a bus; or take a bus. You'll gain 1 hour traveling from Panama City to Antigua due to the time zone difference. Expect a bit cooler weather when traveling from Panama City in April: highs in Antigua hover around 32°C, while lows dip to 17°C. Cap off your sightseeing on the 26th (Sun) early enough to travel to Cozumel.

Things to do in Antigua

Parks Historic Sites Museums

Side Trips

Valhalla Experimental Station, La Azotea
Highlights from your plan
Volcán Pacaya ©
Volcán Pacaya
Arco de Santa Catalina ©
Arco de Santa Catalina
Casa Santo Domingo Museums ©
Casa Santo Domingo Museums

4
nights
Cozumel, Mexico

Cozumel ©
Thanks to the island's outstanding scuba diving and snorkeling options, Cozumel tourism sector remains a major employer and the main source of income for this Caribbean getaway.
You'll discover tucked-away gems like Palancar Reef and The Amazing Cozumel Race. There's much more to do: see the interesting displays at The Mayan Cacao Company, relax in the rural setting at Rancho Universo Heal a Horse Cozumel Horse Sanctuary Non-Profit Organization, take in the dramatic natural features at El Paso del Cedral Reef, and kick back and relax at Playa El Cielo.

To find traveler tips, photos, and other tourist information, read our Cozumel trip planner .

Traveling by combination of shuttle and flight from Antigua to Cozumel takes 7.5 hours. Alternatively, you can do a combination of bus and ferry. The time zone changes from Central Standard Time (CST) to Eastern Standard Time (EST), which is usually a 1 hour difference. Expect somewhat warmer evenings in Cozumel when traveling from Antigua in April, with lows around 24°C. Wrap up your sightseeing on the 1st (Fri) early enough to drive to Tulum.

Things to do in Cozumel

Wildlife Parks Outdoors
Highlights from your plan
Palancar Reef ©
Palancar Reef
The Mayan Cacao Company ©
The Mayan Cacao Company
Scuba & Snorkeling

5
nights
Tulum, Mexico

The only Mayan site built to overlook the ocean, Tulum remains a coastal paradise preserving the last vestiges of a pre-Hispanic civilization.
Step off the beaten path and head to Climbing Tours and Cenote Santa Cruz. Take a break from Tulum with a short trip to Xcaret Park in Playa del Carmen, about 56 minutes away. There's still lots to do: explore the fascinating underground world of Cenotes Sac Actun, stroll through Mayan Beach, explore the ancient world of Tulum Archaeological Site, and head outdoors with Ziggy Beach.

To find where to stay, reviews, maps, and other tourist information, use the Tulum day trip planner .

You can drive from Cozumel to Tulum in 2.5 hours. In May in Tulum, expect temperatures between 34°C during the day and 25°C at night. Wrap up your sightseeing on the 6th (Wed) to allow time to travel back home.

Things to do in Tulum

Outdoors Parks Tours

Side Trips

Akumal, Xcaret Park
Highlights from your plan
Climbing Tours
Cenotes Sac Actun ©
Cenotes Sac Actun
Cenote Santa Cruz ©
Cenote Santa Cruz

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