50 days in Colombia, Mexico & Panama City Itinerary

50 days in Colombia, Mexico & Panama City Itinerary

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Route & dates

50 days in Colombia, Mexico & Panama City Itinerary

Start: Phoenix, United States
Fly:  13 h 30 min
1
Bogota, Colombia
— 11 nights
Fly:  1 h 15 min
2
Medellin, Colombia
— 8 nights
Fly:  4 h 15 min
3
Santa Marta, Colombia
— 4 nights
Drive:  3 h 30 min
4
Cartagena, Colombia
— 8 nights
Fly:  2 h
5
Panama City, Panama
— 4 nights
Fly:  7 h 30 min
6
Mexico City, Mexico
— 6 nights
Fly:  4 h 30 min
7
Guadalajara, Mexico
— 8 nights
Fly:  6 h 15 min
End: Phoenix, United States

11
nights
Bogota, Colombia

Colombia's heart and soul, Bogota has earned the nickname "Athens of South America" thanks to its abundance of universities, libraries, and lower-level schools.
Explore the numerous day-trip ideas around Bogota: Catedral de Sal de Zipaquira (in Zipaquira), Laguna de Guatavita (in Tierra Negra) and Centro de Memoria El Cuartico (in Valledupar). Next up on the itinerary: examine the collection at Gold Museum (Museo del Oro), make a trip to Bolivar plaza, take in nature's colorful creations at Jardin Botanico de Bogota Jose Celestino Mutis, and explore the world behind art at Museo Botero del Banco de la Republica.

Plan a Bogota trip in moments using our itinerary builder.

Phoenix, USA to Bogota is an approximately 13.5-hour flight. You can also do a combination of bus and flight; or do a combination of flight and bus. You'll lose 2 hours traveling from Phoenix to Bogota due to the time zone difference. Traveling from Phoenix in June, things will get much colder in Bogota: highs are around 66°F and lows about 49°F. Wrap up your sightseeing on the 13th (Sat) early enough to travel to Medellin.

Things to do in Bogota

Parks Museums Historic Sites

Side Trips

Centro de Memoria El Cuartico, Basilica Del Señor de los Milagros, Catedral de Sal de Zipaquira, Laguna de Guatavita
Highlights from your plan
Food Tours
Gold Museum (Museo del Oro) ©
Gold Museum (Museo del Oro)
Monserrate ©
Monserrate

8
nights
Medellin, Colombia

Nestled between rising hills in a narrow valley, Medellin serves as an energetic melting pot of people from all socio-economic classes.
Explore the numerous day-trip ideas around Medellin: Parque Tematico Replica del Viejo Penol (in Penol) and Piedra Del Penol (in Guatape). There's much more to do: get the lay of the land with Walking tours, explore the activities along Laguna de Guatape, don't miss a visit to Plaza Botero, and admire the natural beauty at Jardin Botanico de Medellin.

For ratings, reviews, where to stay, and other tourist information, refer to the Medellin trip site .

Traveling by flight from Bogota to Medellin takes 1.5 hours. Alternatively, you can do a combination of flight and shuttle; or drive. Expect a bit warmer temperatures when traveling from Bogota in June; daily highs in Medellin reach 83°F and lows reach 64°F. Cap off your sightseeing on the 21st (Sun) early enough to travel to Santa Marta.

Things to do in Medellin

Parks Tours Outdoors

Side Trips

Piedra Del Penol, Parque Tematico Replica del Viejo Penol, Parroquia la Nina Maria
Highlights from your plan
Off-Road Tours
Walking tours
medellin 2000m DESCENT ©
medellin 2000m DESCENT

4
nights
Santa Marta, Colombia

Santa Marta ©
Many visitors begin their Santa Marta holiday, surrounded by urban clutter and heavy traffic, expecting little from the city in terms of historical importance.
Santa Marta is known for nature, beaches, and wildlife. Your plan includes some of its best attractions: explore the wealth of natural beauty at Parque Nacional Natural Tayrona, examine the collection at Museo del Oro Tairona - Casa de la Aduana, admire the masterpieces at Quinta de San Pedro Alejandrino, and look for all kinds of wild species at Wildlife Areas.

To find where to stay, photos, and more tourist information, refer to the Santa Marta vacation builder .

You can fly from Medellin to Santa Marta in 4.5 hours. Other options are to do a combination of flight and bus; or drive. Expect a bit warmer temperatures when traveling from Medellin in June; daily highs in Santa Marta reach 93°F and lows reach 79°F. Cap off your sightseeing on the 25th (Thu) early enough to go by car to Cartagena.

Things to do in Santa Marta

Parks Outdoors Beaches

Side Trip

Playa Grande
Highlights from your plan
Parque Nacional Natural Tayrona ©
Parque Nacional Natural Tayrona
Scuba & Snorkeling
Quinta de San Pedro Alejandrino ©
Quinta de San Pedro Alejandrino

8
nights
Cartagena, Colombia

Cartagena ©
The site of the continent's first Spanish colony, Cartagena retains much of its colonial flavor thanks to a World Heritage-listed old town, encircled by old walls and protected by imposing fortresses.
Go for a jaunt from Cartagena to Isla Baru to see Playa Blanca about 1h 05 min away. There's still lots to do: step into the grandiose world of Castillo de San Felipe de Barajas, contemplate the geological forces at Volcan de Lodo El Totumo (Mud Volcano), get a new perspective on things with Boat Tours & Water Sports, and don't miss a visit to Torre del Reloj.

To find where to stay, other places to visit, maps, and other tourist information, refer to the Cartagena day trip planner.

You can drive from Santa Marta to Cartagena in 3.5 hours. Another option is to take a bus. Expect a daytime high around 91°F in June, and nighttime lows around 79°F. Finish up your sightseeing early on the 3rd (Fri) so you can travel to Panama City.

Things to do in Cartagena

Historic Sites Outdoors Tours

Side Trip

Playa Blanca
Highlights from your plan
Castillo de San Felipe de Barajas ©
Castillo de San Felipe de Barajas
Walled City of Cartagena ©
Walled City of Cartagena
Plaza Santo Domingo ©
Plaza Santo Domingo

4
nights
Panama City, Panama

Panama City ©
Arguably the most modern of Central American cities, Panama City boasts a shimmering skyline of glass skyscrapers.
Panama City is known for historic sites, shopping, and museums. Your plan includes some of its best attractions: make a trip to Panama Canal, wander the streets of Cinta Costera, appreciate the extensive heritage of Avenida Balboa, and take in the views from Bridge of the Americas.

To see where to stay, other places to visit, ratings, and more tourist information, read our Panama City trip maker tool .

You can fly from Cartagena to Panama City in 2 hours. In July, plan for daily highs up to 88°F, and evening lows to 77°F. Finish your sightseeing early on the 7th (Tue) so you can travel to Mexico City.

Things to do in Panama City

Historic Sites Neighborhoods Outdoors
Highlights from your plan
Panama Canal ©
Panama Canal
Casco Viejo ©
Casco Viejo
Amador Causeway (Calzada de Amador) ©

6
nights
Mexico City, Mexico

Mexico City ©
Breathtakingly large, Mexico City provides a home for almost 9 million people living in nearly 1,700 distinct neighborhoods.
Go for a jaunt from Mexico City to San Juan Teotihuacan to see Zona Arqueológica de Teotihuacan Estacionamiento Puerta 5 about 1h 15 min away. There's lots more to do: take an in-depth tour of Museo Nacional de Antropologia, steep yourself in history at Basilica de Santa Maria de Guadalupe, step into the grandiose world of Chapultepec Castle, and admire the masterpieces at Palacio de Bellas Artes.

To find ratings, more things to do, where to stay, and more tourist information, go to the Mexico City trip itinerary tool .

Traveling by flight from Panama City to Mexico City takes 7.5 hours. Alternatively, you can drive; or take a bus. Traveling from Panama City to Mexico City, you'll gain 1 hour due to the time zone difference. When traveling from Panama City in July, plan for a bit cooler days and much colder nights in Mexico City: temperatures range from 74°F by day to 56°F at night. Wrap up your sightseeing on the 13th (Mon) to allow time to travel to Guadalajara.

Things to do in Mexico City

Historic Sites Museums Neighborhoods

Side Trip

Zona Arqueológica de Teotihuacan Estacionamiento Puerta 5
Highlights from your plan
Museo Nacional de Antropologia ©
Museo Nacional de Antropologia
Palacio de Bellas Artes ©
Palacio de Bellas Artes
Museo Frida Kahlo ©
Museo Frida Kahlo

8
nights
Guadalajara, Mexico

Guadalajara ©
One of Mexico's cultural hubs, Guadalajara represents the home of mariachi music and hosts numerous large-scale events, ranging from international film festivals to celebrated book fairs.
Explore the numerous day-trip ideas around Guadalajara: Ajijic Malecon (in Ajijic), Destileria La Rojena (in Tequila) and Guachimontones (in Teuchitlan). And it doesn't end there: see the interesting displays at Instituto Cultural Cabanas, explore the world behind art at Museo Pantaleon Panduro, get to know the resident critters at Zoologico Guadalajara, and test your problem-solving skills at popular escape rooms.

To see maps, photos, reviews, and tourist information, read Guadalajara online day trip planner .

Traveling by flight from Mexico City to Guadalajara takes 4.5 hours. Alternatively, you can drive; or do a combination of bus and flight. Traveling from Mexico City in July, you will find days in Guadalajara are a bit warmer (80°F), and nights are about the same (61°F). Finish up your sightseeing early on the 21st (Tue) so you can travel back home.

Things to do in Guadalajara

Historic Sites Museums Parks

Side Trips

Tlaquepaque, Chapala Malecon, Destileria La Rojena, Guachimontones, Ajijic Malecon
Highlights from your plan
Acuario Michin Guadalajara ©
Acuario Michin Guadalajara
Instituto Cultural Cabanas ©
Instituto Cultural Cabanas
Museo Pantaleon Panduro ©
Museo Pantaleon Panduro

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