25 days in South America & Mexico Itinerary

25 days in South America & Mexico Itinerary

Created using Inspirock itinerary planner

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1
Buenos Aires, Argentina
— 3 nights
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2
Valparaiso, Chile
— 1 night
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La Paz, Bolivia
— 1 night
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Cusco, Peru
— 2 nights
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Lima, Peru
— 2 nights
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Machu Picchu, Peru
— 1 night
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Quito, Ecuador
— 2 nights
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Cali, Colombia
— 1 night
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Medellin, Colombia
— 1 night
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Bogota, Colombia
— 2 nights
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Cartagena, Colombia
— 2 nights
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Mexico City, Mexico
— 4 nights
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Buenos Aires, Argentina

Queen of La Plata

Cultural capital of South America, Buenos Aires remains one of the largest cities on the continent, serving as a point of departure for exploring the rest of the country.
Buenos Aires is known for historic sites, nightlife, and parks. Your plan includes some of its best attractions: make a trip to Cemiterio de Recoleta, admire the striking features of El Ateneo Grand Splendid, wander the streets of Puerto Madero, and visit Calle Defensa.

To see other places to visit, maps, and other tourist information, use the Buenos Aires travel planning website.

London, UK to Buenos Aires is an approximately 18-hour flight. Due to the time zone difference, you'll gain 3 hours traveling from London to Buenos Aires. Plan for warmer temperatures traveling from London in December, with highs in Buenos Aires at 33°C and lows at 23°C. Cap off your sightseeing on the 9th (Thu) early enough to travel to Valparaiso.

Things to do in Buenos Aires

Historic Sites · Museums · Neighborhoods · Parks

1
night
Valparaiso, Chile

Jewel of the Pacific

Navigating through a maze of colorful streets winding up and down steep hills remains an integral part of any Valparaiso tour.
On the 10th (Fri), see the interesting displays at La Sebastiana, then visit Paseo Dimalow, then admire the landmark architecture of Edificio Luis Cousino, and finally get the lay of the land with Walking tours. Get ready for a full day of sightseeing on the 11th (Sat): admire the striking features of Palacio Rioja, explore the historical opulence of Palacio Valle, then examine the collection at Corporacion Museo de Arqueologia e Historia Francisco Fonck, and finally make a trip to Flower Clock (Reloj de Flores).

To find reviews, photos, where to stay, and other tourist information, read our Valparaiso day trip app.

Traveling by flight from Buenos Aires to Valparaiso takes 7 hours. Alternatively, you can drive; or take a bus. Due to the time zone difference, you'll gain 1 hour traveling from Buenos Aires to Valparaiso. In December, Valparaiso is little chillier than Buenos Aires - with highs of 24°C and lows of 15°C. Wrap up your sightseeing on the 11th (Sat) to allow time to travel to La Paz.

Things to do in Valparaiso

Tours · Museums · Historic Sites · Neighborhoods

Side Trip

1
night
La Paz, Bolivia

City that Touches the Sky

Take a moment to catch your breath as you commence your holiday in La Paz.
On the 12th (Sun), get the adrenaline pumping with an extreme tour, then make a trip to Mercado de Las Brujas, and then make a trip to Calle Sagarnaga.

To see photos, more things to do, traveler tips, and more tourist information, go to the La Paz online travel planner.

You can fly from Valparaiso to La Paz in 7.5 hours. Other options are to take a bus; or drive. In December, La Paz is a bit cooler than Valparaiso - with highs of 18°C and lows of 3°C. Wrap up your sightseeing on the 12th (Sun) early enough to travel to Cusco.

Things to do in La Paz

Outdoors · Tours

2
nights
Cusco, Peru

Imperial City

Capital of the Inca Empire for three centuries, World Heritage-listed Cusco is now a major tourist destination, drawing nearly 2 million annual tourists with its well-preserved colonial architecture and proximity to Machu Picchu.
Start off your visit on the 13th (Mon): admire the masterpieces at Museo de Arte Precolombino, steep yourself in history at Sacsayhuaman, and then admire the striking features of Centro Historico De Cusco. On your second day here, take in the spiritual surroundings of Qorikancha, steep yourself in history at Plaza de Armas, and then contemplate the long history of Tipon.

For traveler tips, other places to visit, more things to do, and more tourist information, refer to the Cusco online travel route planner.

You can fly from La Paz to Cusco in 4.5 hours. Other options are to drive; or take a bus. The time zone difference when traveling from La Paz to Cusco is minus 1 hour. Prepare for somewhat warmer weather when traveling from La Paz in December: high temperatures in Cusco hover around 24°C and lows are around 9°C. Finish your sightseeing early on the 14th (Tue) so you can travel to Lima.

Things to do in Cusco

Historic Sites · Museums

2
nights
Lima, Peru

City of the Kings

Founded in 1535 by Spanish explorer Francisco Pizarro, Lima represents an interesting blend of modern attractions and preserved colonial architecture, much of it clustered in the World Heritage-listed city center.
Kick off your visit on the 15th (Wed): admire the local landmark of Plaza de Armas (Plaza Mayor), then steep yourself in history at Huaca Pucllana, and then make a trip to Miraflores. Here are some ideas for day two: get a taste of the local shopping with Shopping Center Larcomar (Centro Comercial Larcomar), get engrossed in the history at Museo Larco, then get engrossed in the history at Museo Convento San Francisco y Catacumbas, and finally stroll around Circuito Magico Del Agua.

Inspirock's itinerary builder makes planning a Lima trip simple and quick.

Getting from Cusco to Lima by flight takes about 3.5 hours. Other options: drive; or take a bus. Plan for a bit warmer temperatures traveling from Cusco in December, with highs in Lima at 28°C and lows at 22°C. Finish up your sightseeing early on the 16th (Thu) so you can travel to Machu Picchu.

Things to do in Lima

Historic Sites · Museums · Parks · Neighborhoods

1
night
Machu Picchu, Peru

A symbol of the Incan civilization, the abandoned city of Machu Picchu represents a must-see on a Peru vacation.
Start off your visit on the 17th (Fri): indulge in some personalized pampering at SPA Rocas Sagradas and then steep yourself in history at Santuario Historico de Machu Picchu.

To find maps, more things to do, traveler tips, and more tourist information, use the Machu Picchu trip planner.

Traveling by flight from Lima to Machu Picchu takes 7 hours. Alternatively, you can drive; or do a combination of bus and taxi. On the 18th (Sat), you'll have the morning to explore before heading off to Quito.

Things to do in Machu Picchu

Historic Sites · Spas · Shopping

2
nights
Quito, Ecuador

Light of America

High in the Andean foothills, Quito remains one of the world's most photogenic capital cities, featuring two dramatic mountain ranges as its backdrop.
Kick off your visit on the 19th (Sun): make a trip to Mitad Del Mundo, take an in-depth tour of Museo Templo del Sol Pintor Ortega Maila, admire the landmark architecture of Iglesia y Convento de San Francisco, take in the spiritual surroundings of Fundacion Iglesia de la Compania, then take in the spiritual surroundings of El Sagrario, and finally pause for some serene contemplation at Basilica de Nuestra Senora de la Merced.

To see traveler tips, maps, more things to do, and tourist information, read our Quito trip itinerary planning website.

Traveling by flight from Machu Picchu to Quito takes 12 hours. Alternatively, you can drive; or do a combination of car and bus. In December, daily temperatures in Quito can reach 26°C, while at night they dip to 15°C. Finish your sightseeing early on the 20th (Mon) to allow enough time to travel to Cali.

Things to do in Quito

Historic Sites · Museums

1
night
Cali, Colombia

Salsa Capital of the World

Learning how to salsa may be the most popular thing to do in Cali, but this giant city in southwestern Colombia represents more than just the "Salsa Capital of the World." Home to over 2 million people, thriving Cali serves as a major commercial and industrial center in South America, boasting the fastest-growing economy in Colombia.
On the 20th (Mon), push the limits with Picoloro Ecoturismo.

Make your Cali itinerary with Inspirock to find out what to see and where to go.

You can fly from Quito to Cali in 7 hours. Other options are to take a bus; or drive. In December, Cali is a bit warmer than Quito - with highs of 35°C and lows of 22°C. Wrap up your sightseeing by early afternoon on the 21st (Tue) to allow enough time to travel to Medellin.

Things to do in Cali

Parks · Trails · Outdoors · Tours

1
night
Medellin, Colombia

City of the Eternal Spring

Nestled between rising hills in a narrow valley, Medellin serves as an energetic melting pot of people from all socio-economic classes.
To see traveler tips, maps, ratings, and other tourist information, read Medellin online trip builder.

You can fly from Cali to Medellin in 4 hours. Other options are to drive; or take a bus. While traveling from Cali, expect little chillier days and about the same nights in Medellin, ranging from highs of 32°C to lows of 20°C. Finish your sightseeing early on the 22nd (Wed) to allow enough time to travel to Bogota.

Things to do in Medellin

Tours · Adventure · Outdoors · Historic Sites

2
nights
Bogota, Colombia

Athens of South America

Colombia's heart and soul, Bogota has earned the nickname "Athens of South America" thanks to its abundance of universities, libraries, and lower-level schools.
Kick off your visit on the 23rd (Thu): take in the awesome beauty at Monserrate, then explore the world behind art at Museo Botero del Banco de la Republica, and then contemplate the long history of Bolivar Square. Here are some ideas for day two: savor the flavors at Food & Drink, examine the collection at Gold Museum (Museo del Oro), and then stop by Vitrina Guayca.

For more things to do, photos, other places to visit, and more tourist information, use the Bogota online trip maker.

You can fly from Medellin to Bogota in 3.5 hours. Alternatively, you can drive; or take a bus. Traveling from Medellin in December, things will get slightly colder in Bogota: highs are around 22°C and lows about 9°C. Finish your sightseeing early on the 24th (Fri) to allow enough time to travel to Cartagena.

Things to do in Bogota

Museums · Tours · Parks · Nature

2
nights
Cartagena, Colombia

City of Heroes

The site of the continent's first Spanish colony, Cartagena retains much of its colonial flavor thanks to a World Heritage-listed old town, encircled by old walls and protected by imposing fortresses.
Kick off your visit on the 25th (Sat): steep yourself in history at Walled City of Cartagena, explore the historical opulence of Castillo de San Felipe de Barajas, and then observe the fascinating underwater world at Oceanario.

For traveler tips, maps, reviews, and other tourist information, go to the Cartagena route planner.

You can fly from Bogota to Cartagena in 4.5 hours. Other options are to drive; or take a bus. Prepare for much hotter weather when traveling from Bogota in December: high temperatures in Cartagena hover around 37°C and lows are around 28°C. Cap off your sightseeing on the 26th (Sun) early enough to travel to Mexico City.

Things to do in Cartagena

Historic Sites · Parks · Zoos & Aquariums

Side Trip

4
nights
Mexico City, Mexico

City of Palaces

Breathtakingly large, Mexico City provides a home for almost 9 million people living in nearly 1,700 distinct neighborhoods.
Mexico City is known for museums, historic sites, and nightlife. Your plan includes some of its best attractions: learn more about the world around you at Museo Nacional de Antropologia, learn the secrets of beer at a beer tour and tasting, delve into the distant past at Metropolitan Cathedral (Catedral Metropolitana), and see the interesting displays at Museo Frida Kahlo.

To see ratings, where to stay, and other tourist information, you can read our Mexico City trip itinerary planning tool.

Traveling by flight from Cartagena to Mexico City takes 8 hours. The time zone changes from Colombia Standard Time (COT) to Central Standard Time (CST), which is usually a -1 hour difference. When traveling from Cartagena in December, plan for slightly colder days in Mexico City, with highs around 26°C, while nights are much colder with lows around 9°C. Cap off your sightseeing on the 30th (Thu) early enough to travel back home.

Things to do in Mexico City

Historic Sites · Museums · Tours · Breweries & Distilleries

Mexico travel guide

4.5
Ruins · Beaches · Landmarks
Tailor-made for anyone seeking that traditional sun-and-sand experience, Mexico vacations allow visitors to explore nearly 10,000 km (6,200 mi) of picturesque coastlines. Idyllic beaches and favorable year-round weather aside, this diverse country with a rich pre-Colombian history allows tourists a chance to discover a fascinating cuisine, numerous archaeological sites, state-of-the-art museums, colonial-era haciendas, and outstanding examples of 21st-century architecture. Most visitors get to know the country by its cities, but if you want a well-rounded Mexico tour, spend some time exploring its jungles, cloud forests, Caribbean reefs, snowcapped volcanoes, vast deserts, and tranquil lagoons. Life is lived outdoors in Mexico, so wherever you go, don't forget to dine alfresco and stroll the country's colonial streets.