21 days in South America Itinerary

21 days in South America Itinerary

Created using Inspirock South America vacation planner

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Route & dates

21 days in South America Itinerary

Start: Madrid, Spain
Fly:  14​h 45​min
1
Cusco, Peru
— 4 nights
Fly:  11​h 45​min
2
Huaraz, Peru
— 3 nights
Fly:  15​h 15​min
3
Salta, Argentina
— 3 nights
Fly:  7​h
4
El Calafate, Argentina
— 2 nights
Fly:  2​h
5
Ushuaia, Argentina
— 3 nights
+2
Fly + taxi + bus:  7​h 30​min
6
Puerto Natales (Torres del Paine), Chile
— 3 nights
Fly:  22​h 30​min
End: Madrid, Spain

4
nights
Cusco, Peru

Capital of the Inca Empire for three centuries, World Heritage-listed Cusco is now a major tourist destination, drawing nearly 2 million annual tourists with its well-preserved colonial architecture and proximity to Machu Picchu.
Discover out-of-the-way places like Horseback Riding Tours and Sacred Valley of the Incas. Do some cultural sightseeing at Sacsayhuaman and Museo Quechua. Take a break from Cusco with a short trip to Moray in Maras, about 1h 20 min away. It doesn't end there: take in the dramatic natural features at Montana de Siete Colores.

To see reviews, other places to visit, traveler tips, and other tourist information, use the Cusco vacation tool .

Madrid, Spain to Cusco is an approximately 15-hour flight. Due to the time zone difference, you'll gain 6 hours traveling from Madrid to Cusco. Traveling from Madrid in October, expect a bit cooler with lows of 7°C in Cusco. Cap off your sightseeing on the 15th (Tue) early enough to travel to Huaraz.

Things to do in Cusco

Historic Sites Outdoors Tours

Side Trips

Moray, Sacred Valley of the Incas
Highlights from your plan
Horseback Riding Tours
Sacsayhuaman ©
Sacsayhuaman
Sacred Valley of the Incas ©
Sacred Valley of the Incas

3
nights
Huaraz, Peru

Huaraz ©
One of the main cities in the Peruvian Andes, Huaraz mainly draws those seeking adventure out in the landscape.
On the 16th (Wed), indulge your thirst for a good beer at Sierra Andina, head outdoors with Infinite Adventures, and then identify plant and animal life at Callejon de Conchucos. On your second day here, explore the different monuments and memorials at Cementerio General Presbitero Villon, look for gifts at Mercado Central, and then trek along Laguna Wilcacocha.

Inspirock's itinerary builder makes planning a Huaraz trip simple and quick.

Fly from Cusco to Huaraz in 12 hours. Alternatively, you can drive; or take a bus. In October, daily temperatures in Huaraz can reach 28°C, while at night they dip to 8°C. Finish up your sightseeing early on the 18th (Fri) so you can travel to Salta.

Things to do in Huaraz

Outdoors Parks Trails
Highlights from your plan
Laguna Wilcacocha ©
Laguna Wilcacocha
Cementerio General Presbitero Villon ©

3
nights
Salta, Argentina

Salta boasts a vibrant social life and array of informative museums appealing to visitors looking for a memorable cultural experience.
Your cultural itinerary includes sights like Iglesia San Francisco and MAAM - Museo de Arqueologia de Alta Montana de Salta. You'll explore the less-touristy side of things at Horseback Riding Tours and Ojo de Mar. The adventure continues: make a trip to Iglesia Nuestra Senora de La Candelaria de La Vina, head outdoors with Overland Salta, get great views at El Mirador, and contemplate in the serene atmosphere at Immaculada Madre del Divino Corazon Eucaristico de Jesus.

To see where to stay, maps, ratings, and tourist information, you can read our Salta online itinerary planner .

The Route module can help you plan travel from Huaraz to Salta. The time zone difference moving from Peru Time to Argentine Time is 2 hours. Traveling from Huaraz in October, plan for somewhat warmer nights in Salta, with lows around 13°C. Wrap up your sightseeing on the 21st (Mon) early enough to travel to El Calafate.

Things to do in Salta

Outdoors Tours Historic Sites

Side Trips

Tolar Grande, Horseback Riding Tours
Highlights from your plan
Horseback Riding Tours
Iglesia San Francisco ©
Iglesia San Francisco

2
nights
El Calafate, Argentina

El Calafate ©
El Calafate tourism thrives mostly thanks to the city's proximity to a World Heritage-listed national park, famed for containing over 40 large glaciers.
Kick off your visit on the 22nd (Tue): explore the striking landscape of Parque Nacional Los Glaciares. Keep things going the next day: get outside with Enjoy!, then see the interesting displays at El Calafate Historical Interpretation Center, then get a new perspective on nature at Museo Regional Municipal de El Calafate, and finally pause for some serene contemplation at Santa Teresita del Nino Jesus.

To find reviews, maps, other places to visit, and tourist information, you can read our El Calafate trip builder website .

Traveling by flight from Salta to El Calafate takes 7 hours. Alternatively, you can do a combination of bus, taxi, and flight; or drive. Expect cooler weather when traveling from Salta in October: highs in El Calafate hover around 9°C, while lows dip to 8°C. Wrap up your sightseeing on the 23rd (Wed) to allow time to travel to Ushuaia.

Things to do in El Calafate

Nature Parks Outdoors
Highlights from your plan
Parque Nacional Los Glaciares ©
Parque Nacional Los Glaciares
Santa Teresita del Nino Jesus ©
Santa Teresita del Nino Jesus

3
nights
Ushuaia, Argentina

Ushuaia ©
Often called the "End of the World" because of its position on the southernmost tip of South America, the expanding city of Ushuaia serves as both a busy commercial port and attractive tourist hub.
Step out of the city life by going to Lago Roca and Ushuaia Bay. Get a sense of the local culture at CASA BEBAN and Museo Maritimo y del Presidio de Ushuaia. The adventure continues: surround yourself with nature on a nature and wildlife tour, take your sightseeing to a higher altitude at Glaciar Martial, appreciate the history behind Monumento Antiguos Pobladores de Ushuaia, and explore the wealth of natural beauty at Tierra del Fuego National Park.

To find where to stay, traveler tips, reviews, and other tourist information, use the Ushuaia trip itinerary planning tool .

Traveling by flight from El Calafate to Ushuaia takes 2 hours. Alternatively, you can do a combination of car and ferry; or take a bus. Plan for slightly colder nights when traveling from El Calafate in October since evenings lows in Ushuaia dip to 3°C. Wrap up your sightseeing on the 26th (Sat) early enough to travel to Puerto Natales (Torres del Paine).

Things to do in Ushuaia

Parks Outdoors Nature

Side Trips

Lago Roca, Glaciar Martial
Highlights from your plan
Lago Roca ©
Lago Roca
Nature & Wildlife Tours
Ushuaia Bay ©
Ushuaia Bay

3
nights
Puerto Natales (Torres del Paine), Chile

Surrounded by towering mountains, shimmering lakes, and the region's rugged hills, Puerto Natales serves as a bustling jumping-off point for exploring the Torres del Paine National Park.
Do some cultural sightseeing at Museo Historico e Industrial Puerto Bories and Le Mouton Vert, Patagonia Merino Sheep Wool. Escape the urban bustle at Kayaking & Canoeing and Patagonia Line. The adventure continues: take a pleasant ride with a tour on horseback, Head underground at Mylodon Cave Natural Monument, take in the exciting artwork at La Tehuelche, and explore the wealth of natural beauty at Bernardo O'Higgins National Park.

Plan trip to Puerto Natales (Torres del Paine) with our itinerary maker to find out where to go and what to do.

You can do a combination of flight and bus from Ushuaia to Puerto Natales (Torres del Paine) in 7.5 hours. Other options are to take a bus; or take a bus. Traveling from Ushuaia to Puerto Natales (Torres del Paine), you'll gain 1 hour due to the time zone difference. In October, daily temperatures in Puerto Natales (Torres del Paine) can reach 13°C, while at night they dip to 6°C. Finish up your sightseeing early on the 30th (Wed) so you can travel back home.

Things to do in Puerto Natales (Torres del Paine)

Outdoors Tours Adventure
Highlights from your plan
Kayaking & Canoeing
Horseback Riding Tours
Mylodon Cave Natural Monument ©
Mylodon Cave Natural Monument

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