21 days in South America Itinerary

21 days in South America Itinerary

Created using Inspirock South America route planner

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Route & dates

1
Santiago, Chile
— 3 nights
2
Copiapo, Chile
— 2 nights
3
Chanaral, Chile
— 1 day
4
Uyuni, Bolivia
— 1 night
5
Cusco, Peru
— 4 nights
6
Lima, Peru
— 3 nights
7
Quito, Ecuador
— 2 nights
8
Cartagena, Colombia
— 2 nights

3
nights
Santiago, Chile

Santiago ©
Santiago tourism thrives largely thanks to the city's big selection of cultural and entertainment options, including museums, theaters, restaurants, bars, and giant malls.
Santiago is known for shopping, parks, and museums. Your plan includes some of its best attractions: walk around Cerro Santa Lucia, see the interesting displays at La Chascona, take in panoramic vistas at Sky Costanera, and take your sightseeing to a higher altitude at San Cristóbal Hill.

For more things to do, photos, and tourist information, read our Santiago trip builder app.

Sao Paulo, Brazil to Santiago is an approximately 8-hour flight. You can also drive; or take a bus. You'll gain 1 hour traveling from Sao Paulo to Santiago due to the time zone difference. Finish up your sightseeing early on the 8th (Thu) so you can travel to Copiapo.

Things to do in Santiago

Parks Shopping Museums
Highlights from your plan
San Cristóbal Hill ©
San Cristóbal Hill
Cerro Santa Lucia ©
Cerro Santa Lucia
La Chascona ©
La Chascona

2
nights
Copiapo, Chile

Copiapo ©
Surrounded by the Atacama Desert, Copiapo receives very little rainfall and owes its existence to the mining industry.
Kick off your visit on the 9th (Fri): make a trip to Parroquia Nuestra Senora de la Candelaria, thencontemplate the waterfront views at Laguna Verde, thenadmire nature's extreme beauty at Desierto Florido, and finally pause for some photo ops at Locomotora Copiapo.

To find photos, traveler tips, more things to do, and tourist information, read our Copiapo trip planner.

Traveling by flight from Santiago to Copiapo takes 4.5 hours. Alternatively, you can drive; or take a bus. Wrap up your sightseeing on the 10th (Sat) to allow time to travel to Chanaral.

Things to do in Copiapo

Parks Nature Wildlife
Highlights from your plan
Desierto Florido ©
Desierto Florido
Parroquia Nuestra Senora de la Candelaria ©
Locomotora Copiapo ©
Locomotora Copiapo

1
day
Chanaral, Chile

Chanaral ©
Chañaral is a small coastal city and commune in the Atacama Region, Chile and capital of the Chañaral Province. Start off your visit on the 10th (Sat): make a trip to Plaza de Armas and then explore the striking landscape of Pan de Azucar National Park.

To see where to stay, more things to do, photos, and other tourist information, go to the Chanaral tour itinerary planning app.

Traveling by car from Copiapo to Chanaral takes 2 hours. Wrap up your sightseeing on the 10th (Sat) early enough to travel to Uyuni.

Things to do in Chanaral

Parks Nature
Highlights from your plan
Pan de Azucar National Park ©
Pan de Azucar National Park
Plaza de Armas ©
Plaza de Armas

1
night
Uyuni, Bolivia

Uyuni ©
Emptiness surrounds the desert outpost of Uyuni, the gateway to the world's largest salt flats.
Kick off your visit on the 11th (Sun): step off the mainland to explore Isla Incahuasi and then take in the dramatic natural features at Salar de Uyuni. On the 12th (Mon), you'll have a packed day of sightseeing: learn more about the world around you at Museo Arquecologia y Antropologico de los Andes Meridionales and then examine the collection at Train Cemetery.

To see traveler tips, more things to do, and other tourist information, use the Uyuni online route planner.

The Route module can help you plan travel from Chanaral to Uyuni. In October, plan for daily highs up to °C, and evening lows to °C. Wrap up your sightseeing on the 12th (Mon) early enough to travel to Cusco.

Things to do in Uyuni

Parks Nature Museums
Highlights from your plan
Salar de Uyuni ©
Salar de Uyuni
Isla Incahuasi ©
Isla Incahuasi
Train Cemetery ©
Train Cemetery

4
nights
Cusco, Peru

Cusco ©
Capital of the Inca Empire for three centuries, World Heritage-listed Cusco is now a major tourist destination, drawing nearly 2 million annual tourists with its well-preserved colonial architecture and proximity to Machu Picchu.
When in Cusco, make a side trip to see Salinas de Maras in Maras, approximately Maras away. There's lots more to do: steep yourself in history at Sacsayhuaman, delve into the distant past at Sacred Valley of the Incas, take in the local highlights with Walking tours, and contemplate in the serene atmosphere at Qorikancha.

To find reviews, where to stay, photos, and other tourist information, use the Cusco trip planner.

Traveling by flight from Uyuni to Cusco takes 7 hours. Alternatively, you can drive; or do a combination of taxi and bus. The time zone difference moving from Bolivia Time to Peru Standard Time is minus 1 hour. Traveling from Uyuni in October, you will find days in Cusco are much hotter (°C), and nights are about the same (°C). Finish up your sightseeing early on the 16th (Fri) so you can travel to Lima.

Things to do in Cusco

Historic Sites Tours Parks

Side Trips

Sacred Valley of the Incas, Salinas de Maras
Highlights from your plan
Sacsayhuaman ©
Sacsayhuaman
Centro Historico De Cusco ©
Centro Historico De Cusco
Qorikancha ©
Qorikancha

3
nights
Lima, Peru

Lima ©
Founded in 1535 by Spanish explorer Francisco Pizarro, Lima represents an interesting blend of modern attractions and preserved colonial architecture, much of it clustered in the World Heritage-listed city center.
Lima is known for museums, parks, and historic sites. Your plan includes some of its best attractions: get engrossed in the history at Museo Larco, savor the flavors at Food & Drink, walk around Circuito Magico Del Agua, and get a taste of the local shopping with Shopping Center Larcomar (Centro Comercial Larcomar).

For more things to do, where to stay, maps, and tourist information, go to the Lima road trip planner.

Getting from Cusco to Lima by flight takes about 3.5 hours. Other options: drive; or take a bus. Traveling from Cusco in October, you can expect nighttime temperatures to be somewhat warmer in Lima, with lows of °C. Cap off your sightseeing on the 19th (Mon) early enough to travel to Quito.

Things to do in Lima

Historic Sites Tours Neighborhoods
Highlights from your plan
Huaca Pucllana ©
Huaca Pucllana
Museo Larco ©
Museo Larco
Plaza de Armas (Plaza Mayor) ©
Plaza de Armas (Plaza Mayor)

2
nights
Quito, Ecuador

Quito ©
High in the Andean foothills, Quito remains one of the world's most photogenic capital cities, featuring two dramatic mountain ranges as its backdrop.
On the 20th (Tue), stop by La Mundial Custom Boots, make a trip to Mitad Del Mundo, thentake an in-depth tour of Museo Templo del Sol Pintor Ortega Maila, thenadmire the landmark architecture of Fundacion Iglesia de la Compania, and finally appreciate the extensive heritage of Quito Old Town. Here are some ideas for day two: admire the masterpieces at Casa Museo Guayasamin, thentake an in-depth tour of Museum of Maria Augusta Urrutia (La Casa Museo Maria Augusta Urrutia), thenadmire the landmark architecture of Iglesia y Convento de San Francisco, and finally contemplate in the serene atmosphere at Basilica del Voto Nacional.

To find maps, other places to visit, where to stay, and more tourist information, you can read our Quito travel route planner.

Traveling by flight from Lima to Quito takes 6 hours. Alternatively, you can drive; or take a bus. Expect a daytime high around °C in October, and nighttime lows around °C. Wrap up your sightseeing by early afternoon on the 22nd (Thu) to allow time for travel to Cartagena.

Things to do in Quito

Historic Sites Museums Shopping
Highlights from your plan
Museo Templo del Sol Pintor Ortega Maila ©
Museo Templo del Sol Pintor Ortega Maila
Fundacion Iglesia de la Compania ©
Fundacion Iglesia de la Compania
Mitad Del Mundo ©
Mitad Del Mundo

2
nights
Cartagena, Colombia

Cartagena ©
The site of the continent's first Spanish colony, Cartagena retains much of its colonial flavor thanks to a World Heritage-listed old town, encircled by old walls and protected by imposing fortresses.
On the 23rd (Fri), steep yourself in history at Walled City of Cartagena, thentake in the architecture and atmosphere at Sanctuary of Saint Peter Claver, thenexplore the historical opulence of Castillo de San Felipe de Barajas, and finally look for gifts at El Centro Artesano. Get ready for a full day of sightseeing on the next day: get engrossed in the history at Museo del Oro Zenu, thentake in the spiritual surroundings of Convent of Santa Cruz de la Popa, and then steep yourself in history at Plaza Santo Domingo.

To see other places to visit, traveler tips, maps, and other tourist information, go to the Cartagena trip itinerary site.

Traveling by flight from Quito to Cartagena takes 8 hours. Alternatively, you can do a combination of bus and taxi; or drive. Prepare for somewhat warmer weather when traveling from Quito in October: high temperatures in Cartagena hover around °C and lows are around °C. Cap off your sightseeing on the 24th (Sat) early enough to travel back home.

Things to do in Cartagena

Historic Sites Museums Shopping
Highlights from your plan
Walled City of Cartagena ©
Walled City of Cartagena
Castillo de San Felipe de Barajas ©
Castillo de San Felipe de Barajas
Convent of Santa Cruz de la Popa ©
Convent of Santa Cruz de la Popa

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