21 days in South America Itinerary

21 days in South America Itinerary

Created using Inspirock South America holiday planner

Plan created by another user. Make it yours

Route & dates

1
Brasilia, Brazil
— 2 nights
2
Buenos Aires, Argentina
— 4 nights
3
Santiago, Chile
— 4 nights
4
Calama, Chile
— 1 night
5
Cusco, Peru
— 5 nights
6
Cartagena, Colombia
— 4 nights

2
nights
Brasilia, Brazil

Brasilia ©
Although it lacks the cultural flair of Rio de Janeiro and the massive urban sprawl of Sao Paulo, Brasilia holds a fascinating place in the tapestry of Brazil.
Brasilia is known for museums, shopping, and historic sites. Your plan includes some of its best attractions: admire the striking features of Catedral Metropolitana, take in the waterfront at Pontao do Lago Sul, look for all kinds of wild species at Atlantic Forest South-East Reserves, and examine the collection at Museo Nacional.

Inspirock's itinerary builder makes planning a Brasilia trip simple and quick.

If you are flying in from Brazil, the closest major aiport is Presidente Juscelino Kubistschek International Airport. In December, daytime highs in Brasilia are °C, while nighttime lows are °C. Cap off your sightseeing on the 1st (Fri) early enough to travel to Buenos Aires.

Things to do in Brasilia

Historic Sites Parks Museums
Highlights from your plan
Catedral Metropolitana ©
Catedral Metropolitana
Pontao do Lago Sul ©
Pontao do Lago Sul
Santuario Dom Bosco ©
Santuario Dom Bosco

4
nights
Buenos Aires, Argentina

Buenos Aires ©
Cultural capital of South America, Buenos Aires remains one of the largest cities on the continent, serving as a point of departure for exploring the rest of the country.
Buenos Aires is known for historic sites, nightlife, and parks. Your plan includes some of its best attractions: explore the different monuments and memorials at Cemiterio de Recoleta, admire the architecture and history at Plaza de Mayo, appreciate the extensive heritage of Calle Defensa, and steep yourself in history at Casa Rosada.

For reviews, other places to visit, maps, and tourist information, read our Buenos Aires road trip tool.

Traveling by flight from Brasilia to Buenos Aires takes 7.5 hours. Alternatively, you can drive; or do a combination of bus and car. Expect a daytime high around °C in January, and nighttime lows around °C. Finish your sightseeing early on the 5th (Tue) to allow enough time to travel to Santiago.

Things to do in Buenos Aires

Historic Sites Museums Neighborhoods
Highlights from your plan
Cemiterio de Recoleta ©
Cemiterio de Recoleta
Puerto Madero ©
Puerto Madero
Plaza de Mayo ©
Plaza de Mayo

4
nights
Santiago, Chile

Santiago ©
Santiago tourism thrives largely thanks to the city's big selection of cultural and entertainment options, including museums, theaters, restaurants, bars, and giant malls.
Santiago is known for shopping, parks, and museums. Your plan includes some of its best attractions: take your sightseeing to a higher altitude at San Cristóbal Hill, admire the striking features of Metropolitan Cathedral (Catedral Metropolitana), walk around Cerro Santa Lucia, and take in the pleasant sights at Plaza de Armas.

To find other places to visit, traveler tips, where to stay, and tourist information, go to the Santiago travel planner.

You can fly from Buenos Aires to Santiago in 6 hours. Other options are to drive; or take a bus. The time zone difference moving from Argentina Standard Time to Chile Standard Time is minus 1 hour. Wrap up your sightseeing on the 9th (Sat) early enough to travel to Calama.

Things to do in Santiago

Museums Parks Shopping
Highlights from your plan
La Chascona ©
La Chascona
San Cristóbal Hill ©
San Cristóbal Hill
Cerro Santa Lucia ©
Cerro Santa Lucia

1
night
Calama, Chile

Calama ©
A hub of northern Chile's copper mining industry, Calama acts as a gateway for exploration of the geological and archaeological sites in the Atacama desert region.
Kick off your visit on the 10th (Sun): take in the architecture and atmosphere at Catedral de San Juan Bautista and then head outdoors with Sol Del Desierto.

For other places to visit, reviews, ratings, and other tourist information, you can read our Calama trip planner.

Traveling by flight from Santiago to Calama takes 4.5 hours. Alternatively, you can drive; or take a bus. January in Calama sees daily highs of °C and lows of °C at night. Cap off your sightseeing on the 10th (Sun) early enough to travel to Cusco.

Things to do in Calama

Outdoors Historic Sites
Highlights from your plan
Sol Del Desierto ©
Sol Del Desierto
Catedral de San Juan Bautista ©
Catedral de San Juan Bautista

5
nights
Cusco, Peru

Cusco ©
Capital of the Inca Empire for three centuries, World Heritage-listed Cusco is now a major tourist destination, drawing nearly 2 million annual tourists with its well-preserved colonial architecture and proximity to Machu Picchu.
Explore the numerous day-trip ideas around Cusco: Cerveceria Willkamayu (in Urubamba) and Yucay Museo de Cultura Viva (in Yucay). And it doesn't end there: contemplate the long history of Sacsayhuaman, pause for some serene contemplation at Cusco Cathedral, take an in-depth tour of Museo Inka, and delve into the distant past at Qorikancha.

To see more things to do, ratings, where to stay, and more tourist information, read our Cusco trip planner.

Use the Route module to find suitable travel options from Calama to Cusco. Due to the time zone difference, you'll gain 1 hour traveling from Calama to Cusco. When traveling from Calama in January, plan for little chillier days and about the same nights in Cusco: temperatures range from °C by day to °C at night. Wrap up your sightseeing by early afternoon on the 15th (Fri) to allow enough time to travel to Cartagena.

Things to do in Cusco

Historic Sites Outdoors Tours

Side Trips

Cerveceria Willkamayu, Yucay Museo de Cultura Viva, Sacred Valley of the Incas
Highlights from your plan
Sacsayhuaman ©
Sacsayhuaman
Sacred Valley of the Incas ©
Sacred Valley of the Incas
Centro Historico De Cusco ©
Centro Historico De Cusco

4
nights
Cartagena, Colombia

Cartagena ©
The site of the continent's first Spanish colony, Cartagena retains much of its colonial flavor thanks to a World Heritage-listed old town, encircled by old walls and protected by imposing fortresses.
Cartagena is known for historic sites, museums, and nightlife. Your plan includes some of its best attractions: contemplate the long history of Walled City of Cartagena, take in the architecture and atmosphere at Sanctuary of Saint Peter Claver, get up close and personal with brilliant marine life at Oceanario, and indulge your taste buds at Food & Drink.

To see reviews, maps, photos, and other tourist information, read Cartagena trip itinerary tool.

You can fly from Cusco to Cartagena in 9.5 hours. Other options are to drive; or do a combination of bus and taxi. In January, Cartagena is warmer than Cusco - with highs of °C and lows of °C. Wrap up your sightseeing on the 19th (Tue) early enough to travel back home.

Things to do in Cartagena

Historic Sites Tours Outdoors

Side Trip

Oceanario
Highlights from your plan
Walled City of Cartagena ©
Walled City of Cartagena
Castillo de San Felipe de Barajas ©
Castillo de San Felipe de Barajas
Boat Tours & Water Sports

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