21 days in Chile Itinerary

Packed with old stone churches in a unique urban landscape, La Serena represents one of Chile's oldest settlements, equally popular with architecture buffs and beachgoers.

Start off your visit on the 14th (Sun): step off the mainland to explore Isla Damas and then appreciate the views at Valle del Elqui.

Plan my trip to La Serena with suggested itineraries provided by Inspirock.

Brussels, Belgium to La Serena is an approximately 21-hour combination of train and flight. You can also do a combination of train and flight. Due to the time zone difference, you'll gain 5 hours traveling from Brussels to La Serena. Expect somewhat warmer temperatures when traveling from Brussels in April; daily highs in La Serena reach 21°C and lows reach 13°C. Finish your sightseeing early on the 14th (Sun) so you can travel to Santiago.

Santiago tourism thrives largely thanks to the city's big selection of cultural and entertainment options, including museums, theaters, restaurants, bars, and giant malls.

Kick off your visit on the 15th (Mon): walk around Cerro Santa Lucia, then admire the striking features of Metropolitan Cathedral (Catedral Metropolitana), then take in the awesome beauty at San Cristóbal Hill, and finally browse the exhibits of Centro Cultural Palacio de la Moneda y Plaza de la Ciudadania. Get ready for a full day of sightseeing on the next day: see the interesting displays at La Chascona, then look for gifts at Patio Bellavista, and then hit the slopes at Valle Nevado - Ski Resort Chile.

For maps, ratings, traveler tips, and more tourist information, you can read our Santiago tour planning website.

Traveling by flight from La Serena to Santiago takes 3.5 hours. Alternatively, you can drive; or take a bus. Cap off your sightseeing on the 16th (Tue) early enough to travel to Puerto Natales (Torres del Paine).

Surrounded by towering mountains, shimmering lakes, and the region's rugged hills, Puerto Natales serves as a bustling jumping-off point for exploring the Torres del Paine National Park.

Get ready for a full day of sightseeing on the 18th (Thu): see Madre Roca Patagonia.

For other places to visit, more things to do, maps, and tourist information, you can read our Puerto Natales (Torres del Paine) trip planner.

Traveling by combination of flight and bus from Santiago to Puerto Natales (Torres del Paine) takes 9 hours. Alternatively, you can drive; or take a bus. April in Puerto Natales (Torres del Paine) sees daily highs of 13°C and lows of 5°C at night. Wrap up your sightseeing on the 18th (Thu) to allow time to travel to Puerto Rio Tranquilo.

Sandwiched between a sapphire lake and a mountainous Patagonian national park, Puerto Rio Tranquilo makes an excellent base for outdoor tourism.

Start off your visit on the 19th (Fri): get outside with Glaciar Exploradores, Head underground at Marble Cathedrals, and then explore the activities along Bayo Lake.

To find photos, maps, ratings, and more tourist information, go to the Puerto Rio Tranquilo trip itinerary maker website.

You can drive from Puerto Natales (Torres del Paine) to Puerto Rio Tranquilo in 17 hours. Expect a daytime high around 15°C in April, and nighttime lows around 3°C. Cap off your sightseeing on the 19th (Fri) early enough to travel to Puerto Varas.

Overlooking a lake, with a conical volcano looming in the background, Puerto Varas enjoys memorable scenery but retains its authentic atmosphere.

On the 20th (Sat), admire the masterpieces at Museo Pablo Fierro, then contemplate the geological forces at Volcan Osorno, and then cast your line with a fishing tour. Here are some ideas for day two: explore the wealth of natural beauty at Parque Nacional Vicente Perez Rosales.

To see photos, other places to visit, and tourist information, read Puerto Varas online road trip planner.

You can do a combination of shuttle, bus, and flight from Puerto Rio Tranquilo to Puerto Varas in 8 hours. Other options are to take a bus; or drive. In April, plan for daily highs up to 18°C, and evening lows to 7°C. Finish up your sightseeing early on the 21st (Sun) so you can travel to Neltume.

The small Chilean town of Neltume was the site of social and civil unrest for decades, especially under the regime of Augusto Pinochet.

Start off your visit on the 22nd (Mon): take an in-depth tour of Neltume Cultural Center, Museum and Memorial, then explore the activities along Lago Pirehueico, then hike along Saltos del Huilo-Huilo, and finally hike along Sendero el Puma.

For reviews, other places to visit, where to stay, and more tourist information, read our Neltume trip maker.

Traveling by car from Puerto Varas to Neltume takes 4 hours. Wrap up your sightseeing on the 22nd (Mon) early enough to drive to Pucon.

Nestled in the shadow of the snow-capped Villarrica volcano, Pucon ranks among the world's premier destinations for adventure sports and high-thrills activities.

Start off your visit on the 23rd (Tue): explore the wealth of natural beauty at Huerquehue National Park. Get ready for a full day of sightseeing on the 24th (Wed): explore the activities along Lake Caburga and then get the adrenaline pumping with Go Volcano.

To find more things to do, ratings, maps, and other tourist information, you can read our Pucon road trip website.

Traveling by car from Neltume to Pucon takes 2.5 hours. Finish up your sightseeing early on the 24th (Wed) so you can travel to Hanga Roa.

The main town and capital of Chile's Easter Island, Hanga Roa serves as a base for most visitors to the island, with all explorations of Easter Island and its famous moai monoliths beginning here.

On the 25th (Thu), contemplate the geological forces at Rano Kau, explore the activities along Orongo, then don't miss a visit to Ahu Tongariki, and finally explore the ancient world of Ahu Akahanga. Get ready for a full day of sightseeing on the next day: explore the striking landscape of Rapa Nui Parque Nacional.

To find reviews, photos, traveler tips, and more tourist information, read Hanga Roa online trip builder.

Do a combination of bus and flight from Pucon to Hanga Roa in 17.5 hours. Alternatively, you can do a combination of bus, shuttle, and flight; or do a combination of bus and flight. The time zone changes from Chile Standard Time to Easter Island Standard Time, which is usually a -2 hour difference. In April, daytime highs in Hanga Roa are 29°C, while nighttime lows are 22°C. Wrap up your sightseeing on the 26th (Fri) early enough to travel to Iquique.

Thanks to the city's position on the Pacific coast, vacations in Iquique appeal to beachgoers, paragliders, bodyboarders, nature lovers, photographers, and fans of picture-perfect sunsets.

On the 27th (Sat), explore the fascinating landscape at Parque Nacional Salar del Huasco and then see a world frozen in time at Oficina Salitrera Santiago Humberstone. Get ready for a full day of sightseeing on the next day: kick back and relax at Playa Cavancha, then don't miss a visit to Santuario Sagrado Corazon de Jesus de Iquique, then witness a stunning natural landmark at Geisers of Puchuldiza, and finally get engrossed in the history at Museo Corbeta Esmeralda.

To see photos, other places to visit, maps, and other tourist information, go to the Iquique online trip itinerary builder.

Fly from Hanga Roa to Iquique in 11.5 hours. The time zone difference when traveling from Hanga Roa to Iquique is 2 hours. Wrap up your sightseeing on the 28th (Sun) early enough to take a bus to San Pedro de Atacama.

Major archeological sites and a renowned museum remain the big draws in San Pedro de Atacama tourism, appealing to visitors interested in learning more about South America's pre-Columbian cultures.

Discover out-of-the-way places like Reserva Nacional de Flamencos and Tebinquinche Lake. Get outdoors at Piedras Rojas and Geyser del Tatio. And it doesn't end there: identify plant and animal life at Wildlife Areas, explore the striking landscape at Valle De La Luna, delve into the distant past at Pukara de Quitor, and don't miss a visit to Mirador de Kari, Piedra del Coyote.

To find out how to plan a trip to San Pedro de Atacama, use our trip itinerary maker.

You can take a bus from Iquique to San Pedro de Atacama in 6.5 hours. Alternatively, you can drive; or fly. Expect a daytime high around 28°C in April, and nighttime lows around 4°C. Finish your sightseeing early on the 2nd (Thu) to allow enough time to travel back home.