45 days in South America Itinerary

45 days in South America Itinerary

Created using Inspirock South America itinerary planner

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Route & dates

45 days in South America Itinerary

Start: Cancun, Mexico
Fly:  10​h
1
Lima, Peru
— 3 nights
Fly:  2​h
2
Huaraz, Peru
— 4 nights
Drive:  5​h 30​min
3
Trujillo, Peru
— 2 nights
Drive:  10​h 30​min
4
Chachapoyas, Peru
— 2 nights
Drive:  5​h 30​min
5
Tarapoto, Peru
— 1 night
Fly:  4​h
6
Cusco, Peru
— 5 nights
+2
bus + foot + train:  3​h 30​min
7
Machu Picchu, Peru
— 3 nights
Drive:  12​h 30​min
8
Arequipa, Peru
— 2 nights
Drive:  4​h 30​min
9
Puno, Peru
— 3 nights
Drive:  4​h
10
La Paz, Bolivia
— 1 night
Fly + taxi:  4​h
11
Uyuni, Bolivia
— 1 night
Drive:  11​h 30​min
12
San Pedro de Atacama, Chile
— 2 nights
shuttle + Fly:  5​h
13
Santiago, Chile
— 2 nights
Fly:  6​h
14
Punta Arenas, Chile
— Few hours
bus:  3​h
15
Puerto Natales (Torres del Paine), Chile
— 3 nights
Drive:  11​h
16
Perito Moreno, Argentina
— 1 night
Drive:  4​h 30​min
17
Puerto Rio Tranquilo, Chile
— 1 night
taxi + Fly:  9​h
18
Puerto Montt, Chile
— 2 nights
Fly:  19​h 30​min
End: Madrid, Spain

3
nights
Lima, Peru

Lima ©
Founded in 1535 by Spanish explorer Francisco Pizarro, Lima represents an interesting blend of modern attractions and preserved colonial architecture, much of it clustered in the World Heritage-listed city center.
On the 13th (Sun), get engrossed in the history at Museo Larco, then get a dose of the wild on a nature and wildlife tour, and then explore the world behind art at MALI - Museo de Arte de Lima. On the 14th (Mon), you'll have a packed day of sightseeing: delve into the distant past at Huaca Pucllana, then wander the streets of San Isidro, then pause for some serene contemplation at Iglesia y Convento de San Francisco, and finally take in the spiritual surroundings of Iglesia de las Nazarenas.

To find where to stay, photos, more things to do, and more tourist information, go to the Lima online day trip planner .

Cancun, Mexico to Lima is an approximately 10-hour flight. Traveling from Cancun in October, expect Lima to be slightly colder, temps between 24°C and 19°C. Wrap up your sightseeing by early afternoon on the 15th (Tue) to allow enough time to travel to Huaraz.

Things to do in Lima

Historic Sites Museums Tours
Highlights from your plan
San Isidro ©
San Isidro
MALI - Museo de Arte de Lima ©
MALI - Museo de Arte de Lima
Museo Larco ©
Museo Larco

4
nights
Huaraz, Peru

Huaraz ©
One of the main cities in the Peruvian Andes, Huaraz mainly draws those seeking adventure out in the landscape.
Get a sense of the local culture at Camposanto de Yungay and Iglesia La Soledad. Escape the urban bustle at Los Olivos and Infinite Adventures. Go for a jaunt from Huaraz to Pampas Chico to see Hatun Machay Rock Forest about 1h 10 min away. And it doesn't end there: look for all kinds of wild species at Callejon de Conchucos, make a trip to Plaza de Armas, see the interesting displays at The Archeology Museum of Ancash, and stop by RUBRIX.

For more things to do, where to stay, and tourist information, go to the Huaraz vacation planner .

Traveling by flight from Lima to Huaraz takes 2 hours. Alternatively, you can drive; or do a combination of flight and car. While traveling from Lima, expect a bit warmer days and slightly colder nights in Huaraz, ranging from highs of 28°C to lows of 8°C. Finish your sightseeing early on the 19th (Sat) so you can drive to Trujillo.

Things to do in Huaraz

Parks Nature Wildlife

Side Trips

Camposanto de Yungay, Laguna Querococha, Hatun Machay Rock Forest
Highlights from your plan
Los Olivos ©
Los Olivos
Colonia Adventures E.I.R.L ©
Colonia Adventures E.I.R.L
Camposanto de Yungay ©
Camposanto de Yungay

2
nights
Trujillo, Peru

Trujillo ©
Considered the country's capital of culture, Trujillo was the birthplace of the North Group, a community of artists and intellectuals that included celebrated poet Cesar Vallejo and notable novelist Ciro Alegria.
Start off your visit on the 20th (Sun): steep yourself in history at Huaca del Sol y la Luna, contemplate the long history of Casa Orbegoso, look for all kinds of wild species at Huanchaco Al Rescate, then explore the ancient world of Chan Chan, and finally examine the collection at Casa de la Emancipacion.

To see traveler tips, where to stay, reviews, and more tourist information, read Trujillo day trip website .

Traveling by car from Huaraz to Trujillo takes 5.5 hours. Alternatively, you can take a bus. Expect slightly colder weather when traveling from Huaraz in October: highs in Trujillo hover around 24°C, while lows dip to 19°C. On the 21st (Mon), wrap the sightseeing up by early afternoon so you can drive to Chachapoyas.

Things to do in Trujillo

Historic Sites Parks Wildlife

Side Trip

Huanchaco Al Rescate
Highlights from your plan
Chan Chan ©
Chan Chan
Huaca del Sol y la Luna ©
Huaca del Sol y la Luna
Huaca El Dragon ©
Huaca El Dragon

2
nights
Chachapoyas, Peru

Chachapoyas ©
A good base for exploring the surrounding cloud forests, Chachapoyas remains a small and laid-back town despite its growing popularity with international tourists.
Step out of the city life by going to Catarata De Gocta and Laguna de Pomacochas. Explore hidden gems such as Sarcofagos de Karajia and Petroglifos de Pitaya. Next up on the itinerary: look for all kinds of wild species at Reserva Nacional Huiquilla, take in breathtaking views at Canon del Sonche, don't miss a visit to Centro Historico, and take a stroll through Distrito de Huancas.

To see other places to visit, maps, traveler tips, and tourist information, refer to the Chachapoyas trip planner.

Traveling by car from Trujillo to Chachapoyas takes 10.5 hours. Alternatively, you can take a bus. Finish up your sightseeing early on the 24th (Thu) so you can go by car to Tarapoto.

Things to do in Chachapoyas

Parks Nature Wildlife

Side Trip

Catarata De Gocta
Highlights from your plan
Catarata De Gocta ©
Catarata De Gocta
Sarcofagos de Karajia ©
Sarcofagos de Karajia
Distrito de Huancas ©
Distrito de Huancas

1
night
Tarapoto, Peru

Tarapoto ©
As a busy commercial hub of northern Peru, Tarapoto straddles the foothills of the Andes and a high jungle plateau characterized by lush cloud forests.
Kick off your visit on the 25th (Fri): identify plant and animal life at Asociacion de Proteccion de Flora y Fauna and then get engrossed in the history at Museo Chanka y de la Diversidad Lamista.

For traveler tips, other places to visit, ratings, and more tourist information, read our Tarapoto tour itinerary maker tool .

You can drive from Chachapoyas to Tarapoto in 5.5 hours. Another option is to take a bus. In October in Tarapoto, expect temperatures between 39°C during the day and 25°C at night. Wrap up your sightseeing on the 25th (Fri) to allow time to travel to Cusco.

Things to do in Tarapoto

Parks Wildlife Museums
Highlights from your plan

5
nights
Cusco, Peru

Cusco ©
Capital of the Inca Empire for three centuries, World Heritage-listed Cusco is now a major tourist destination, drawing nearly 2 million annual tourists with its well-preserved colonial architecture and proximity to Machu Picchu.
Step off the beaten path and head to Sacred Valley of the Incas and Pinkuylluna Mountain Granaries. Visiting Horseback Riding Tours and Santuario Animal de Cochahuasi will get you outdoors. Explore the numerous day-trip ideas around Cusco: San Pedro Apostol de Andahuaylillas (in Andahuaylillas) and Zipline (in Urubamba). Next up on the itinerary: explore the striking landscape at Cerro Colorado Vinicunca, examine the collection at Museo Quechua, delve into the distant past at Q'enqo, and contemplate the long history of Sacsayhuaman.

For other places to visit, where to stay, maps, and tourist information, use the Cusco attractions planner.

Traveling by flight from Tarapoto to Cusco takes 4 hours. Alternatively, you can drive; or take a bus. Traveling from Tarapoto in October, expect Cusco to be much colder, temps between 24°C and 7°C. Wrap up your sightseeing on the 30th (Wed) early enough to travel to Machu Picchu.

Things to do in Cusco

Historic Sites Tours Outdoors

Side Trips

San Pedro Apostol de Andahuaylillas, Pinkuylluna Mountain Granaries, Zipline, Sacred Valley of the Incas
Highlights from your plan
Sacsayhuaman ©
Sacsayhuaman
Horseback Riding Tours
Zipline

3
nights
Machu Picchu, Peru

Machu Picchu ©
A symbol of the Incan civilization, the abandoned city of Machu Picchu represents a must-see on a Peru vacation.
Kick off your visit on the 31st (Thu): explore the ancient world of Santuario Historico de Machu Picchu and then take in nature's colorful creations at Los Jardines de Mandor. On the 1st (Fri), you'll have a packed day of sightseeing: examine the collection at Museo de Sitio Manuel Chavez Ballon, then explore the ancient world of Winay Wayna, then identify plant and animal life at Jardin Botanico en Machu Pichu, and finally get a sense of history and politics at Serpost.

To find more things to do, reviews, traveler tips, and other tourist information, use the Machu Picchu trip builder app .

Getting from Cusco to Machu Picchu by combination of bus and train takes about 3.5 hours. Other options: take a train; or drive. You will have some time to spend on the 2nd (Sat) before leaving for Arequipa.

Things to do in Machu Picchu

Historic Sites Parks Wildlife
Highlights from your plan
Santuario Historico de Machu Picchu ©
Winay Wayna ©
Winay Wayna
Los Jardines de Mandor ©
Los Jardines de Mandor

2
nights
Arequipa, Peru

Arequipa ©
In an area dominated three imposing volcanoes, Arequipa vacations allow visitors to admire well-preserved colonial architecture in a dramatic setting.
Start off your visit on the 3rd (Sun): take an in-depth tour of Museo Santuarios Andinos, admire the masterpieces at San Francisco Plaza, Church and Monastery, then see the interesting displays at Santa Catalina Monastery, then take in the architecture and atmosphere at Iglesia de Yanahuara ( San Juan Bautista), and finally steep yourself in history at Historic Centre of Arequipa. Get ready for a full day of sightseeing on the 4th (Mon): see the interesting displays at Casa Museo Villalobos, see the interesting displays at Casa Museo Mario Vargas Llosa, and then contemplate the long history of Petroglifos de Toro Muerto.

To find other places to visit, maps, and more tourist information, go to the Arequipa online travel route planner .

Drive from Machu Picchu to Arequipa in 12.5 hours. Alternatively, you can do a combination of train and bus; or take a bus. In November, daytime highs in Arequipa are 24°C, while nighttime lows are 11°C. Cap off your sightseeing on the 4th (Mon) early enough to go by car to Puno.

Things to do in Arequipa

Museums Historic Sites

Side Trip

Petroglifos de Toro Muerto
Highlights from your plan
Historic Centre of Arequipa ©
Historic Centre of Arequipa
Santa Catalina Monastery ©
Santa Catalina Monastery

3
nights
Puno, Peru

Puno ©
Hugging the western tip of Lake Titicaca, Puno serves as a melting pot of indigenous and imported cultures, and makes a great base for explorations around the region.
On the 5th (Tue), head off the coast to Taquile Island, then step aboard Yavari Museum, and then contemplate the long history of La Casa del Corregidor. On the 6th (Wed), you'll have a packed day of sightseeing: explore the activities along Lake Titicaca, then explore the activities along Lake Umayo, and then stroll around Parque Pino.

To see more things to do, traveler tips, photos, and tourist information, read Puno trip builder site .

You can drive from Arequipa to Puno in 4.5 hours. Another option is to take a bus. Plan for little chillier nights when traveling from Arequipa in November since evenings lows in Puno dip to 3°C. Cap off your sightseeing on the 7th (Thu) early enough to go by car to La Paz.

Things to do in Puno

Parks Nature Historic Sites
Highlights from your plan
Taquile Island ©
Taquile Island
Lake Titicaca ©
Lake Titicaca
Lake Umayo ©
Lake Umayo

1
night
La Paz, Bolivia

La Paz ©
Take a moment to catch your breath as you commence your holiday in La Paz.
On the 7th (Thu), stop by Mistura - Manifestacion Creativa, then examine the collection at National Museum of Ethnography and Folklore, and then see the winter wonderland with Scree Rush. Here are some ideas for day two: see the interesting displays at Bolivian Drink Museum and then fly down the slopes at Chacaltaya Ski Resort.

To find maps, more things to do, and more tourist information, go to the La Paz day trip planning site .

You can drive from Puno to La Paz in 4 hours. Alternatively, you can take a bus. You'll lose 1 hour traveling from Puno to La Paz due to the time zone difference. Traveling from Puno in November, expect nights in La Paz to be about the same, around 2°C, while days are slightly colder, around 20°C. Wrap up your sightseeing on the 8th (Fri) to allow time to travel to Uyuni.

Things to do in La Paz

Parks Winter Sports Outdoors
Highlights from your plan
Chacaltaya Ski Resort ©
Chacaltaya Ski Resort
Mistura - Manifestacion Creativa ©
Mistura - Manifestacion Creativa

1
night
Uyuni, Bolivia

Uyuni
Emptiness surrounds the desert outpost of Uyuni, the gateway to the world's largest salt flats.
Start off your visit on the 9th (Sat): examine the collection at Necropolis & Museum Kawsay Wasy.

For photos, more things to do, where to stay, and more tourist information, read Uyuni trip planner .

Traveling by combination of flight and taxi from La Paz to Uyuni takes 4 hours. Alternatively, you can drive; or do a combination of bus and taxi. When traveling from La Paz in November, plan for slightly colder days and somewhat warmer nights in Uyuni: temperatures range from 12°C by day to 11°C at night. Wrap up your sightseeing on the 9th (Sat) to allow time to travel to San Pedro de Atacama.

Things to do in Uyuni

Museums

2
nights
San Pedro de Atacama, Chile

San Pedro de Atacama ©
Major archeological sites and a renowned museum remain the big draws in San Pedro de Atacama tourism, appealing to visitors interested in learning more about South America's pre-Columbian cultures.
You'll explore the less-touristy side of things at Piedras Rojas and Museo del Meteorito. Visiting Laguna Chaxa and Valle Arcoiris will get you outdoors. There's much more to do: explore the striking landscape at Valle De La Luna, browse the collection at Libreria Del Desierto, witness a stunning natural landmark at Geyser del Tatio, and don't miss a visit to Mirador de Kari, Piedra del Coyote.

To see maps, traveler tips, other places to visit, and other tourist information, read our San Pedro de Atacama trip itinerary builder website .

You can do a combination of car and bus from Uyuni to San Pedro de Atacama in 11.5 hours. Other options are to drive; or do a combination of car, train, and bus. Expect much warmer weather when traveling from Uyuni in November: highs in San Pedro de Atacama hover around 28°C, while lows dip to 3°C. Wrap up your sightseeing on the 12th (Tue) to allow time to travel to Santiago.

Things to do in San Pedro de Atacama

Parks Nature Outdoors
Highlights from your plan
Laguna Chaxa ©
Laguna Chaxa
Valle Arcoiris ©
Valle Arcoiris
Piedras Rojas ©
Piedras Rojas

2
nights
Santiago, Chile

Santiago ©
Santiago tourism thrives largely thanks to the city's big selection of cultural and entertainment options, including museums, theaters, restaurants, bars, and giant malls.
Start off your visit on the 13th (Wed): do a tasting at Santa Carolina, then take in the awesome beauty at San Cristóbal Hill, then take in the spiritual surroundings of Santuario de la Inmaculada Concepcion, and finally wander the streets of Barrio Italia. Get ready for a full day of sightseeing on the next day: learn about winemaking at Vina Santa Rita and then do a tasting at Vina Undurraga.

To find ratings, where to stay, photos, and tourist information, use the Santiago online travel planner .

Do a combination of shuttle and flight from San Pedro de Atacama to Santiago in 5 hours. Alternatively, you can drive; or take a bus. Finish your sightseeing early on the 14th (Thu) to allow enough time to travel to Punta Arenas.

Things to do in Santiago

Wineries Nature Parks

Side Trips

Vina Santa Rita, Vina Undurraga
Highlights from your plan
Vina Santa Rita ©
Vina Santa Rita
San Cristóbal Hill ©
San Cristóbal Hill
Vina Undurraga ©
Vina Undurraga

few
hours
Punta Arenas, Chile

Punta Arenas
An erstwhile hub of the sheep wool industry, Punta Arenas has evolved into a gateway of sorts for hikers, cruise ship passengers, and adventure travelers heading out on the windswept lands of Chile's extreme southern reaches.
For more things to do, where to stay, reviews, and tourist information, go to the Punta Arenas trip planner .

You can fly from Santiago to Punta Arenas in 6 hours. Alternatively, you can drive; or take a bus. In November, daytime highs in Punta Arenas are 14°C, while nighttime lows are 5°C. On the 15th (Fri), you're off toPuerto Natales (Torres del Paine).

Things to do in Punta Arenas

Tours Outdoors Wildlife

3
nights
Puerto Natales (Torres del Paine), Chile

Surrounded by towering mountains, shimmering lakes, and the region's rugged hills, Puerto Natales serves as a bustling jumping-off point for exploring the Torres del Paine National Park.
Step out of the city life by going to Mylodon Cave Natural Monument and Glaciar Amalia. Discover out-of-the-way places like Fishing Charters & Tours and Muelle Historico. There's still lots to do: explore the wealth of natural beauty at Bernardo O'Higgins National Park, don't miss a visit to Plaza de Armas Arturo Prat, stop by Etnia Souvenirs & Wool, and head outdoors with Patagonia Line.

For maps, ratings, more things to do, and more tourist information, use the Puerto Natales (Torres del Paine) trip maker app .

You can take a bus from Punta Arenas to Puerto Natales (Torres del Paine) in 3 hours. Alternatively, you can drive. Traveling from Punta Arenas in November, Puerto Natales (Torres del Paine) is a bit warmer at night with lows of 9°C. On the 18th (Mon), you'll have the morning to explore before heading off to Perito Moreno.

Things to do in Puerto Natales (Torres del Paine)

Outdoors Nature Parks
Highlights from your plan
Fishing Charters & Tours
Mylodon Cave Natural Monument ©
Mylodon Cave Natural Monument
Glaciar Amalia ©
Glaciar Amalia

1
night
Perito Moreno, Argentina

Perito Moreno
Perito Moreno is a town in the northwest of Santa Cruz Province, Argentina, 25 km east of Lake Buenos Aires. On the 19th (Tue), make a trip to Cave of the Hands.

To find other places to visit, more things to do, and other tourist information, read our Perito Moreno attractions planner.

Traveling by car from Puerto Natales (Torres del Paine) to Perito Moreno takes 11 hours. Traveling from Puerto Natales (Torres del Paine) to Perito Moreno, you'll lose 1 hour due to the time zone difference. When traveling from Puerto Natales (Torres del Paine) in November, plan for somewhat warmer days and about the same nights in Perito Moreno: temperatures range from 20°C by day to 7°C at night. Cap off your sightseeing on the 19th (Tue) early enough to travel to Puerto Rio Tranquilo.
Highlights from your plan
Cave of the Hands
Cave of the Hands

1
night
Puerto Rio Tranquilo, Chile

Puerto Rio Tranquilo ©
Sandwiched between a sapphire lake and a mountainous Patagonian national park, Puerto Rio Tranquilo makes an excellent base for outdoor tourism.
Start off your visit on the 20th (Wed): get impressive views of Parque Nacional Laguna San Rafael and then explore the striking landscape at Marble Cathedrals. Keep things going the next day: look for gifts at Colores del Lago and then contemplate the waterfront views at Bayo Lake.

To see maps, where to stay, ratings, and tourist information, read our Puerto Rio Tranquilo trip builder tool .

You can drive from Perito Moreno to Puerto Rio Tranquilo in 4.5 hours. You'll gain 1 hour traveling from Perito Moreno to Puerto Rio Tranquilo due to the time zone difference. In November, daytime highs in Puerto Rio Tranquilo are 19°C, while nighttime lows are 7°C. Wrap up your sightseeing by early afternoon on the 21st (Thu) to allow time for travel to Puerto Montt.

Things to do in Puerto Rio Tranquilo

Nature Parks Wildlife
Highlights from your plan
Marble Cathedrals ©
Marble Cathedrals
Colores del Lago ©
Colores del Lago

2
nights
Puerto Montt, Chile

Puerto Montt ©
Though the city serves as a regional transport and commercial hub, vacations in Puerto Montt rarely focus on the city itself; instead, Southern Chile's volcanoes, glacial lakes, and national parks get most of the attention here.
Get outdoors at Volcan Osorno and Romahue. Eschew the tourist crowds and head to Parque Nacional Vicente Perez Rosales and Iglesia Inmaculada Concepcion. Change things up with a short trip to Museo Colonial Aleman in Frutillar (about 42 minutes away). The adventure continues: admire the masterpieces at Museo Pablo Fierro and see what you can catch with a fishing tour.

For traveler tips, reviews, and more tourist information, you can read our Puerto Montt online travel route planner .

Traveling by combination of taxi and flight from Puerto Rio Tranquilo to Puerto Montt takes 9 hours. Alternatively, you can do a combination of taxi and bus; or do a combination of car and bus. In November, plan for daily highs up to 19°C, and evening lows to 7°C. Finish your sightseeing early on the 24th (Sun) to allow enough time to travel back home.

Things to do in Puerto Montt

Parks Wildlife Nature

Side Trips

Puerto Varas, Frutillar
Highlights from your plan
Parque Nacional Vicente Perez Rosales ©
Volcan Osorno ©
Volcan Osorno
Museo Colonial Aleman ©
Museo Colonial Aleman

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