15 days in Province of Mendoza & Chile Itinerary

15 days in Province of Mendoza & Chile Itinerary

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Route & dates

15 days in Province of Mendoza & Chile Itinerary

Start: Santiago, Chile
bus + Fly:  2​h
1
Mendoza, Argentina
— 2 nights
Fly + shuttle:  6​h 15​min
2
San Pedro de Atacama, Chile
— 3 nights
shuttle + Fly:  4​h 30​min
3
La Serena, Chile
— 1 night
Fly + bus:  3​h 45​min
4
Casablanca, Chile
— 1 night
Drive:  1​h 30​min
5
Isla de Maipo, Chile
— 1 night
Drive:  4​h 15​min
6
Talca, Chile
— 1 night
Drive:  1​h 45​min
7
Santa Cruz, Chile
— 2 nights
Drive:  2​h
8
Santiago, Chile
— 3 nights
End: Santiago, Chile

2
nights
Mendoza, Argentina

Famed for its neat vineyards and thriving wine production, Mendoza remains the place to visit for a pleasant combination of relaxation and recreation.
When in Mendoza, make a side trip to see Valle de Uco in Tupungato, approximately 1h 20 min away. And it doesn't end there: walk around Parque General San Martin, awaken your taste buds at some of the top wineries in the area, learn about winemaking at Bodega Roberto Bonfanti, and let your taste buds guide you at a local gastronomic tour.

To see where to stay, photos, traveler tips, and tourist information, you can read our Mendoza day trip planner .

Santiago, Chile to Mendoza is an approximately 2-hour combination of bus and flight. You can also drive; or take a bus. You'll lose 1 hour traveling from Santiago to Mendoza due to the time zone difference. Expect a daytime high around 28°C in October, and nighttime lows around 13°C. Cap off your sightseeing on the 7th (Mon) early enough to travel to San Pedro de Atacama.

Things to do in Mendoza

Tours Parks Nature

Side Trip

Valle de Uco
Highlights from your plan
Food Tours
Parque General San Martin ©
Parque General San Martin
Wine Tours & Tastings

3
nights
San Pedro de Atacama, Chile

San Pedro de Atacama ©
Major archeological sites and a renowned museum remain the big draws in San Pedro de Atacama tourism, appealing to visitors interested in learning more about South America's pre-Columbian cultures.
San Pedro de Atacama is known for nature, wildlife, historic sites, nightlife, and museums. Your plan includes some of its best attractions: take in the dramatic natural features at Valle De La Luna, contemplate the waterfront views at Lagunas Miscanti y Miniques, look for all kinds of wild species at Salar de Tara, and don't miss a visit to Mirador de Kari, Piedra del Coyote.

To see traveler tips, maps, where to stay, and tourist information, use the San Pedro de Atacama trip itinerary builder app .

You can do a combination of flight and shuttle from Mendoza to San Pedro de Atacama in 6.5 hours. Other options are to drive; or take a bus. Due to the time zone difference, you'll gain 1 hour traveling from Mendoza to San Pedro de Atacama. Traveling from Mendoza in October, you can expect nighttime temperatures to be a bit cooler in San Pedro de Atacama, with lows of 3°C. Cap off your sightseeing on the 10th (Thu) early enough to travel to La Serena.

Things to do in San Pedro de Atacama

Parks Nature Wildlife
Highlights from your plan
Valle De La Luna ©
Valle De La Luna
Geyser del Tatio ©
Geyser del Tatio
Lagunas Miscanti y Miniques ©
Lagunas Miscanti y Miniques

1
night
La Serena, Chile

La Serena ©
Packed with old stone churches in a unique urban landscape, La Serena represents one of Chile's oldest settlements, equally popular with architecture buffs and beachgoers.
On the 11th (Fri), admire the landmark architecture of Iglesia Santo Domingo, then examine the collection at San Francisco Church, then admire the verdant scenery at Valle del Elqui, and finally stroll around Enchanted Valley (Valle del Encanto).

To find where to stay, ratings, maps, and tourist information, go to the La Serena trip itinerary maker tool .

Do a combination of shuttle and flight from San Pedro de Atacama to La Serena in 4.5 hours. Alternatively, you can do a combination of bus and flight; or drive. Traveling from San Pedro de Atacama in October, you will find days in La Serena are little chillier (20°C), and nights are somewhat warmer (11°C). Finish your sightseeing early on the 11th (Fri) so you can travel to Casablanca.

Things to do in La Serena

Parks Nature Museums
Highlights from your plan
Valle del Elqui ©
Valle del Elqui
San Francisco Church ©
San Francisco Church
Enchanted Valley (Valle del Encanto) ©

1
night
Casablanca, Chile

Casablanca ©
Tour the young and fast-growing wine region of Casablanca, easily accessible from Santiago and Valparaiso.
On the 12th (Sat), stop by Supermercado del Vino, do a tasting at Emiliana Organic Vineyards, and then do a tasting at Matetic Vineyards.

Inspirock's itinerary builder makes planning a Casablanca trip simple and quick.

Traveling by combination of flight and bus from La Serena to Casablanca takes 4 hours. Alternatively, you can drive; or take a bus. In October, daytime highs in Casablanca are 20°C, while nighttime lows are 13°C. Finish your sightseeing early on the 12th (Sat) to allow enough time to drive to Isla de Maipo.

Things to do in Casablanca

Wineries Shopping

Side Trip

Matetic Vineyards
Highlights from your plan
Emiliana Organic Vineyards ©
Emiliana Organic Vineyards
Matetic Vineyards ©
Matetic Vineyards

1
night
Isla de Maipo, Chile

Isla de Maipo
To find maps, reviews, photos, and tourist information, use the Isla de Maipo trip planning site .

You can drive from Casablanca to Isla de Maipo in 1.5 hours. On the 13th (Sun), you'll travel to Talca.

Things to do in Isla de Maipo

Theme Parks Outdoors Tours

1
night
Talca, Chile

Talca ©
Although it provided the setting for the signing of the Chilean declaration of independence in 1818, Talca has lost some of its political power and luster over the years.
On the 14th (Mon), admire the natural beauty at Jardin botanico de la Universidad de Talca, get great views at Mirador Cerro La Virgen, then look for gifts at KUK Artesanias y Souvenirs, and finally explore and take pictures at Pan-American Highway (Ruta 5).

For where to stay, traveler tips, ratings, and other tourist information, read Talca trip itinerary maker website .

Traveling by car from Isla de Maipo to Talca takes 3 hours. October in Talca sees daily highs of 24°C and lows of 9°C at night. Wrap up your sightseeing on the 14th (Mon) to allow time to drive to Santa Cruz.

Things to do in Talca

Outdoors Parks Scenic Drive
Highlights from your plan
Mirador Cerro La Virgen ©
Mirador Cerro La Virgen
KUK Artesanias y Souvenirs ©
KUK Artesanias y Souvenirs

2
nights
Santa Cruz, Chile

Santa Cruz ©
The Chilean city of Santa Cruz offers a view into the country's agricultural and pastoral heritage, with well-preserved colonial-era traditions and architecture.
On the 15th (Tue), learn about winemaking at Viu Manent Winery, do a tasting at Vina Montes, and then stop by Vinonauta. Get ready for a full day of sightseeing on the next day: examine the collection at Colchagua Museum, then do a tasting at Clos Apalta Lapostolle, and then do a tasting at MontGras.

For more things to do, maps, reviews, and more tourist information, use the Santa Cruz trip planner.

Drive from Talca to Santa Cruz in 2 hours. In October, daytime highs in Santa Cruz are 24°C, while nighttime lows are 9°C. Finish your sightseeing early on the 16th (Wed) so you can drive to Santiago.

Things to do in Santa Cruz

Wineries Museums Shopping
Highlights from your plan
Vina Montes ©
Vina Montes
Clos Apalta Lapostolle ©
Clos Apalta Lapostolle
Colchagua Museum ©
Colchagua Museum

3
nights
Santiago, Chile

Santiago ©
Santiago tourism thrives largely thanks to the city's big selection of cultural and entertainment options, including museums, theaters, restaurants, bars, and giant malls.
Santiago is known for shopping, museums, parks, nature, and historic sites. Your plan includes some of its best attractions: take in the awesome beauty at San Cristóbal Hill, enjoy breathtaking views from Grand Santiago Tower, take some stellar pictures from Sky Costanera, and see the interesting displays at La Chascona.

To find reviews, traveler tips, maps, and tourist information, you can read our Santiago trip itinerary maker site .

Getting from Santa Cruz to Santiago by car takes about 2 hours. Other options: do a combination of bus and train; or take a bus. Finish your sightseeing early on the 19th (Sat) so you can travel back home.

Things to do in Santiago

Parks Outdoors Winter Sports

Side Trip

Valle Nevado - Ski Resort Chile
Highlights from your plan
San Cristóbal Hill ©
San Cristóbal Hill
Santa Lucia Hill ©
Santa Lucia Hill
Patio Bellavista ©
Patio Bellavista

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