15 days in North Carolina, South Carolina & Missouri Itinerary

15 days in North Carolina, South Carolina & Missouri Itinerary

Created using Inspirock United States trip builder

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Fly to Piedmont Triad International Airport, Drive to Burlington
1
Burlington
— 1 day
Drive
2
Asheville
— 3 nights
Drive
3
Greenville
— 1 night
Drive
4
Hilton Head
— 1 night
Drive
5
Charleston
— 4 nights
Fly
6
Saint Louis
— 1 night
Drive
7
Branson
— 3 nights
Drive
8
Kansas City
— 1 night
Fly

S M T W T F S
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1
day
Burlington

Burlington is a city in Alamance County in the U.S. On the 14th (Sat), see the interesting displays at Mebane Train Display, then look for all kinds of wild species at Conservators Center, then examine the collection at Textile Heritage Museum, and finally shop like a local with Alamance Arts.

To find photos, more things to do, maps, and more tourist information, read our Burlington trip builder tool.

New York City to Burlington is an approximately 5-hour combination of flight and car. You can also drive. Traveling from New York City in November, plan for slightly colder nights in Burlington, with lows around 37°F. Wrap up your sightseeing on the 14th (Sat) to allow time to travel to Asheville.

Things to do in Burlington

Museums · Parks · Wildlife · Shopping

Side Trips

3
nights
Asheville

Land of the Sky

Asheville nestles between two major mountain ranges in the scenic western section of North Carolina.
Venture out of the city with trips to Max Patch (in Hot Springs) and Crystal Mountain Gem Mine (in Brevard). There's lots more to do: cruise along Blue Ridge Pkwy, stop by Instant Karma Asheville, indulge in some culinary diversions at a local gastronomic tour, and take in the exciting artwork at Lexington Glassworks.

To see more things to do, traveler tips, and other tourist information, refer to the Asheville day trip website.

You can drive from Burlington to Asheville in 3.5 hours. In November, daily temperatures in Asheville can reach 59°F, while at night they dip to 36°F. Finish up your sightseeing early on the 17th (Tue) so you can go by car to Greenville.

Things to do in Asheville

Outdoors · Tours · Wildlife · Scenic Drive

Side Trips

1
night
Greenville

Textile Center of the World

The largest city in "upstate" South Carolina, Greenville has grown around the natural wonders of waterfalls located in the downtown area.
On the 18th (Wed), stroll around Cleveland Park, take in the views from Liberty Bridge, then walk around Falls Park on the Reedy, and finally sample the fine beverages at Dark Corner Distillery.

To see reviews, photos, where to stay, and more tourist information, use the Greenville trip itinerary builder site.

You can drive from Asheville to Greenville in 1.5 hours. Alternatively, you can take a bus. Traveling from Asheville in November, Greenville is a bit warmer at night with lows of 43°F. Wrap up your sightseeing on the 18th (Wed) early enough to drive to Hilton Head.

Things to do in Greenville

Parks · Nature · Breweries & Distilleries

1
night
Hilton Head

A Hilton Head vacation may be heaven for a golfer, but the area also offers all kinds of other options for sports fans.
On the 19th (Thu), trek along Hilton Head Island Bike Trails, identify plant and animal life at Wildlife Areas, and then awaken your taste buds at Carolina Tasting Room.

To see reviews, ratings, and other tourist information, read our Hilton Head trip website.

You can drive from Greenville to Hilton Head in 5 hours. Alternatively, you can fly; or do a combination of bus and taxi. Traveling from Greenville in November, expect a bit warmer with lows of 51°F in Hilton Head. Wrap up your sightseeing on the 19th (Thu) to allow time to drive to Charleston.

Things to do in Hilton Head

Outdoors · Tours · Wildlife · Parks

4
nights
Charleston

Many visitors describe their Charleston holiday as a warm embrace by an old, dear friend--who lived about 200 years ago.
Charleston is known for parks, historic sites, and shopping. Your plan includes some of its best attractions: take a memorable tour with Tours, stroll through Magnolia Plantation & Gardens, get thoroughly spooked out with a ghost and vampire tour, and hit the best photo ops around with an inspiring photography tour.

To find other places to visit, where to stay, traveler tips, and tourist information, go to the Charleston trip app.

Getting from Hilton Head to Charleston by car takes about 2.5 hours. Other options: take a bus. November in Charleston sees daily highs of 68°F and lows of 49°F at night. Finish your sightseeing early on the 23rd (Mon) so you can travel to Saint Louis.

Things to do in Charleston

Historic Sites · Parks · Museums · Tours

1
night
Saint Louis

Gateway to the West

Test the local claim that Saint Louis is second only to Washington, D.C.
On the 24th (Tue), pause for some serene contemplation at Cathedral Basilica of Saint Louis, then enjoy breathtaking views from The Gateway Arch, and then examine the collection at Cardinals Hall of Fame and Museum.

For reviews, maps, where to stay, and more tourist information, refer to the Saint Louis itinerary planner.

You can fly from Charleston to Saint Louis in 4.5 hours. Other options are to drive; or take a bus. The time zone changes from Eastern Standard Time to Central Standard Time, which is usually a -1 hour difference. Traveling from Charleston in November, expect Saint Louis to be slightly colder, temps between 56°F and 35°F. Wrap up your sightseeing on the 24th (Tue) to allow time to drive to Branson.

Things to do in Saint Louis

Historic Sites · Museums

3
nights
Branson

Live Entertainment Capital of the World

Nestled in Missouri's beautiful Ozark Mountains lies one of the country's most attractive vacation towns for year-round family entertainment.
Plan for a day of cool, family-friendly fun on the 25th (Wed) at Silver Dollar City. There's much more to do: take some stellar pictures from College of the Ozarks, get in on the family fun at Runaway Mountain Coaster, pause for some serene contemplation at Our Lady of the Lake Catholic Church, and look for all kinds of wild species at National Tiger Sanctuary.

To find traveler tips, more things to do, ratings, and other tourist information, read our Branson trip itinerary builder site.

Traveling by car from Saint Louis to Branson takes 4.5 hours. Alternatively, you can do a combination of flight and car; or do a combination of bus and taxi. Expect a daytime high around 58°F in November, and nighttime lows around 38°F. Wrap up your sightseeing on the 27th (Fri) to allow time to drive to Kansas City.

Things to do in Branson

Theme Parks · Parks · Wineries · Tours

Side Trip

1
night
Kansas City

City of Fountains

The largest municipality in Missouri, Kansas City has an impressive array of world-class museums, shopping areas, and great places to eat, all of which attract tourism to the area.
Kick off your visit on the 28th (Sat): admire the masterpieces at The Nelson-Atkins Museum of Art and then brush up on your military savvy at National WWI Museum and Memorial.

To see maps, where to stay, reviews, and other tourist information, read Kansas City travel planner.

Traveling by car from Branson to Kansas City takes 4 hours. Alternatively, you can take a bus; or fly. In November, daytime highs in Kansas City are 56°F, while nighttime lows are 38°F. Finish your sightseeing early on the 28th (Sat) to allow enough time to travel back home.

Things to do in Kansas City

Museums

North Carolina travel guide

4.3
Historic Sites · Specialty Museums · Zipline
The Tar Heel State
A top destination for a holiday in nature, North Carolina provides a seemingly endless variety of outdoor activities, including hiking, mountain climbing, and skiing. While the state's rural regions offer a taste of traditional Appalachian music and culture, its increasingly diverse big cities feature modern skyscrapers, renowned museums, and historical neighborhoods perfect for sightseeing tours. The coastal region, famous for its year-round temperate climate, attracts millions of annual visitors, making North Carolina the sixth most-visited state in the country. Though it's hard to find a quiet time of year in coastal North Carolina, the state's inland areas retain many secluded corners where you can experience the laid-back Old South atmosphere.

South Carolina travel guide

4.3
Historic Sites · Dolphin & Whale Watching · Gardens
The Palmetto State
Composed of five distinct geographic regions with boundaries roughly parallel to the Atlantic coastline, South Carolina embraces rich history, scenic beauty, and outstanding cuisine. Originally established as a slave society dependent on the cultivation of rice and indigo, the state now boasts a diverse economy that includes massive production of textile goods, chemical products, machinery, and automobiles. Widely regarded as the beginning of the Deep South, the state remains a deeply conservative part of the country, fervently clinging to its religious and cultural traditions. South Carolinians are kind and open hosts to those who vacation here, eager to share the wealth of their cultural heritage with curious visitors. With many remarkable places to visit like Charleston and Hilton Head, your itinerary here is sure to be diverse and full of scenic attractions.

Missouri travel guide

4.6
Theaters · Performances · Specialty Museums
The Show-Me State
Acquired from France as part of the famous Louisiana Purchase, Missouri offers visitors equal amounts of urban and rural tourist attractions, with a good sprinkling of lush valleys and meandering back roads ideal for leisurely road trips. The state has a highly varied geography, ranging from the till plains in the north to the rolling Ozark Mountains in the south. The state sits at the intersection of North America's three greatest rivers, creating fertile plains known for supporting extensive farms and ranches. Now generally considered part of the country's Midwest, most people used to count Missouri among the southern states, primarily due to its status as a slave state before the Civil War.